Exposure sources of perfluoroalkyl acids and influence of age and gender on concentrations of chlorinated polyfluorinated ether sulfonates in human serum from China

Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats

“…However, emission of PFOS still persists in Asian markets ( 6 , 7 ). A recent study reported that PFOS concentrations in serum are significantly increased with age in the general Chinese population, suggesting that they may have common exposure sources ( 8 ).…”

Per and polyfluoroalkyl substances scientific literature review: water exposure, impact on human health, and implications for regulatory reform

“…A study by Duan et al found novel PFASs PFAES and TFA widely detected in high concentrations in an adult population in Tianjin, China [9]. Jin et al found that an isomer of PFAES concentrations increases with age in a Chinese population in Anji, China [11]. Among Chinese adults, Zeeshan et al observed that blood levels of PFASs were significantly higher in a group with eye disease when compared to a group without such disease.…”

From Pesticides to Per- and Polyfluoroalkyl Substances: An Evaluation of Recent Targeted and Untargeted Mass Spectrometry Methods for Xenobiotics

“…These methods provide both qualitative and quantitative information pertaining to PFAS concentration and occurrence and aid in assessing the amount of exposure in humans and the environment . Typically, targeted methods are designed around standard extraction and separation approaches and often include SPE followed by LC-MS/MS. ,− For example, Hu et al recently used SPE-HPLC-MS/MS to analyze nurses’ blood and tap water for 15 targeted PFAS and were able to detect 11 . This method was also used by Zhang et al to detect PFASs in surface seawater samples and plankton .…”

“…Miaz et al also used this method to detect PFAS in blood samples of first-time mothers . SPE concentration is however not always performed, and LC-MS/MS has been utilized without SPE to examine zebrafish tissue and human serum samples . Kotlarz et al quantified 10 fluoroethers and 10 legacy PFAS in serum collected from adults and children in the Cape Fear River Basin (spatially located near a fluorochemical manufacturing plant) using LC-MS without SPE .…”