Exposure-specific lung cancer risks in Chinese chrysotile textile workers and mining workers

Wang, Xiaorong; Lin, Sihao; Yano, Eiji; Yu, Ignatius Tak-sun; Courtice, Midori N.; Lan, Yajia; Christiani, David C.

doi:10.1016/j.lungcan.2014.04.011

Cited by 21 publications

(13 citation statements)

References 26 publications

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“…Females stay home longer time and cook more frequently, housing related exposure has much stronger influence on them than on males. Wang et al [29] documented that the chrysotile textile workers appeared to have a higher risk of lung cancer than the mining workers at a relatively low exposure level with an interactive effect of asbestos exposure and smoking [30]. Although inhalation of cigarette smoke is a significant risk for lung cancer independent from pack-years [31], Ito et al [32] found that nicotine dependence, as indicated by the time to first cigarette, is associated with increased risk of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer

et al. 2016

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Here, we retrospectively compared the differences in clinicopathological behaviors and prognosis of lung cancer from the First Affiliated Hospital (CMU1, n=513), Shengjing Hospital (CMUS, n=1021), Tumor Hospital (CMUT, n=5378) of China Medical University, the First Affiliated Hospital of Dalian (DMU, n=2251) and Jinzhou (JMU, n=630) Medical University, Takaoka Kouseiren Hospital (Takaoka, n=163) of Japan. Japanese lung cancer patients showed smaller tumor size, lower TNM staging, lower ratio of squamous cell carcinoma and higher ratio of small and large cell carcinomas than Chinese patients (p<0.05). Survival analysis showed that tumor size was employed as a prognostic factor for the Japanese and Chinese cancer patients (p<0.05). In DMU and CMUS, the ratios of female patients or adenocarcinoma were higher than other hospitals (p<0.05), while the patients from CMUT and CMU1 were younger than the others (p<0.05). The ratios of squamous cell carcinoma from CMUT, CMU1 and JMU were higher than the others, while it was the same for the ratio of large and small cell carcinoma in Takaoka and CMU1 (p<0.05). TNM staging was higher in CMUT than JMU and Takaoka (p<0.05). The female patients of lung cancer showed young prone, large tumor size, a high ratio of adenocarcinoma and advanced TNM staging in comparison to the counterpart (p<0.05). The younger patients of lung cancer displayed smaller tumor size, higher ratio of adenocarcinoma, lower TNM staging than the elder in Takaoka (p<0.05). There were more aggressive behaviors and shorter survival time for Chinese than Japanese lung cancer patients. The prevention of lung cancer should be strengthened by establishing a systematic and effective screening strategy, especially for the young and female patients.

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Section: Discussionmentioning

confidence: 99%

The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer

et al. 2016

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“…Important new data relevant to some outstanding questions have also been added. A study of Chinese asbestos miners and textile workers exposed to essentially pure chrysotile reported statistically-significant positive trends in lung cancer mortality with increasing cumulative exposure; notably, among miners, who appeared to have lower risks in some older studies, the smoking-adjusted relative risk per unit of exposure was somewhat higher than among the textile workers (1.20 compared to 1.12 per 100 fiber-years/mL) in the recent Chinese study [ 12 ]. Other pertinent Chinese studies on chrysotile are described below in Section 4 .…”

Section: The Carcinogenic Risk Of Asbestos: Evaluation and Public mentioning

confidence: 99%

Prevention of Asbestos-Related Disease in Countries Currently Using Asbestos

Marsili

Terracini

Santana

et al. 2016

IJERPH

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More than 40 years of evaluation have consistently confirmed the carcinogenicity of asbestos in all of its forms. This notwithstanding, according to recent figures, the annual world production of asbestos is approximatively 2,000,000 tons. Currently, about 90% of world asbestos comes from four countries: Russia, China, Brazil and Kazakhstan; and the wide use of asbestos worldwide represents a global threat. The purpose of this paper is to present a review of the asbestos health impact and to discuss the role of epidemiological investigations in countries where asbestos is still used. In these contexts, new, “local” studies can stimulate awareness of the size of the problem by public opinion and other stakeholders and provide important information on the circumstances of exposure, as well as local asbestos-related health impacts. This paper suggests an agenda for an international cooperation framework dedicated to foster a public health response to asbestos, including: new epidemiological studies for assessing the health impact of asbestos in specific contexts; socio-cultural and economic analyses for contributing to identifying stakeholders and to address both the local and global implications of asbestos diffusion; public awareness on the health and socio-economic impact of asbestos use and banning.

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“…4. The recently published 37-year follow-up cohort studies with chrysotile asbestos miners and textile workers in China by Wang et al [19][20][21][22] and Deng et al 23 showing significant dose-dependent mortality of mesothelioma/lung (SMR 1.46; 95% CI, 0.50, 4.30, P,0.001), larynx, and other cancers as well as of non-malignant disorders 24 . Lung cancer increased with employment years at entry to the study by 3.5-fold in 10 years, and 5.3-fold in 20 years.…”

Section: Stayner Et Almentioning

confidence: 99%

“…The authors showed significant exposure-response relationship with causal links between chrysotile asbestos exposure and lung cancer and non-malignant respiratory diseases. [19][20][21][22][23] The strength of these latter studies by Wang et al [19][20][21][22] is that subjects were exposed to relatively pure chrysotile. As a result of geographical features with the remote location of the mine, workers usually remained with the mine for a lifetime with little opportunity to change their job, eliminating exposure to other occupational carcinogens.…”

Section: Stayner Et Almentioning

confidence: 99%

How conflicted authors undermine the World Health Organization (WHO) campaign to stop all use of asbestos: spotlight on studies showing that chrysotile is carcinogenic and facilitates other non-cancer asbestos-related diseases

Baur

Soskolne

Lemen

et al. 2015

International Journal of Occupational and Environmental Health

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The silicate mineral asbestos is categorized into two main groups based on fiber structure: serpentine asbestos (chrysotile) and amphibole asbestos (crocidolite, amosite, anthophyllite, tremolite, and actinolite). Chrysotile is used in more than 2 000 applications and is especially prevalent in the construction industry. Although its use is banned or restricted in more than 52 countries, an estimated 107 000 workers die from asbestos exposure each year, and approximately 125 million workers continue to be exposed. Furthermore, ambient exposures persist to which the public is exposed, globally. Today, the primary controversies regarding the use of asbestos are the potencies of different types of asbestos, as opposed whether or not asbestos causes morbidity and mortality. The asbestos industry has promoted and funded research based on selected literature, ignoring both clinical and scientific knowledge. In this piece, we highlight a prominent example of a conflicted publication that sought to undermine the World Health Organization (WHO) campaign to stop the use of all forms of asbestos, including chrysotile asbestos. Independent and rigorous scientific data provide sufficient evidence that chrysotile asbestos, like other forms of asbestos, is a cause of asbestos-related morbidity and premature mortality

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Exposure-specific lung cancer risks in Chinese chrysotile textile workers and mining workers

Cited by 21 publications

References 26 publications

The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer

The clinicopathological and prognostic features of Chinese and Japanese inpatients with lung cancer

Prevention of Asbestos-Related Disease in Countries Currently Using Asbestos

How conflicted authors undermine the World Health Organization (WHO) campaign to stop all use of asbestos: spotlight on studies showing that chrysotile is carcinogenic and facilitates other non-cancer asbestos-related diseases

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