Exposure-Time Effect of Cement  Dust on Liver Organ in Rat  (Rattus norvegicus)

Ogenyi, Samuel Ifedioranma; Ike, Amalachukwu Okwukwe; Blessing, Okwuanaso Chetachi; Eberechukwu, God’sman Chidugam; Achilefu, Ramson Chinemerem; Hanson, Sharon Ibilate

doi:10.9734/bji/2022/v26i6663

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…They were processed and embedded in paraffin wax to provide a hard support for sectioning. The sections were mounted on glass slides to make a smear, and stained with hematoxylin and eosin stain (Ogenyi et al, 2022).…”

Section: Histological Examinationmentioning

confidence: 99%

Investigating the Preventive and Therapeutic Role of Costus afer in Acetaminophen Induced Liver Toxicity

Nwisah,

Emeji,

Odiabara

et al. 2023

J. Appl. Health Sci. Med.

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The objective of this study was to determine the prophylatic and therapeutic role of Costus afer in acetaminophen poisoning in rats. The rats were equally divided into two groups; pre-treatment group and post-treatment group with each group have five sub-groups (negative control (NC), positive control (PC), A, B and C) of 5 rats each. NC was without any treatment; PC was treated with 800mg/kg of acetaminophen; A was treated with 200mg/kg of Costus afer; B was treated with 400mg/kg of Costus afer; C was treated with 800mg/kg of Costus afer. In the pre-treatment group, the PC was induced with acetaminophen 28 days after administration of distilled water, and “A”, “B” and “C” were induced with acetaminophen 28 days after Costus afer treatment while in the post-treatment group, the PC was induced with acetaminophen before commencing on 28 days administration of distilled water, and “A”, “B” and “C” were induced with acetaminophen before commencing on 28 days Costus afer treatment. After the treatment period, the rats were sacrificed and sample and liver organ were collected for laboratory analysis for liver enzymes and histological studies. The results showed that there was no significant change (p>0.05) in liver enzymes in the A, B, C subgroups of the pre-treatment group after acetaminophen induction. In the post-treatment group, there was a significant decrease in the liver enzymes in A, B and C subgroups after Costus afer treatment. This study has proven that Costus afer has the potential to not only prevent acetaminophen liver toxicity but to also treat hepatotoxicity inflicted by acetaminophen in rats.

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Section: Histological Examinationmentioning

confidence: 99%

Investigating the Preventive and Therapeutic Role of Costus afer in Acetaminophen Induced Liver Toxicity

Nwisah,

Emeji,

Odiabara

et al. 2023

J. Appl. Health Sci. Med.

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Investigation of Hepatotoxic Effect of Cement-Dust in Occupationally Exposed Individuals in North Central Nigeria

Busari

2024

Preprint

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Background Cement is pivotal in advancing Nigeria's economic and infrastructural development amid rapid urbanization, where the demand for robust infrastructure underscores its integral contribution to meeting developmental requirements. While respiratory concerns have been extensively studied, the impact on the liver with the central role of detoxification remains a critical yet under explored dimension of occupational health. Thus, this study investigated the hepatic effect of cement dust exposure among occupationally exposed individuals in North Central Nigeria. Methods A case-control study was conducted at Malete, Kwara State, North Central Nigeria, to compare the hepatic profiles of 60 individuals occupationally exposed to cement with 60 non-exposed who served as controls. Ethical approval was obtained from the Kwara State Ministry of Health, and informed consent was secured from each participant. Five (5) milliliters of blood were collected, and hepatic profiles were analyzed using standard spectrophotometric methods. Additionally, the study investigated the correlation between the duration of exposure to cement dust and hepatic profiles among those occupationally exposed. Results The study revealed a significant increase in Alanine aminotransaminase (ALT) and alkaline phosphatase (ALP) activities among individuals exposed to cement (ALT: 30.58 ± 11.54, ALP: 181.68 ± 26.25) compared to non-exposed controls (ALT: 19.90 ± 7.26; ALP: 163.68 ± 29.92) at a significance level of p < 0.05. Additionally, the duration of cement dust exposure demonstrated a significant positive correlation with gamma-glutamyl transferase (GGT) activity (r = 0.363; p = 0.004). Conversely, no significant positive correlation was observed between the duration of cement dust exposure and the activities of aspartate aminotransferase (AST) (r = 0.190; p = 0.147), ALT (r = 0.016; p = 0.904), ALP (r = 0.178; p = 0.175), and direct bilirubin (r = 0.057; p = 0.664). Furthermore, the duration of cement dust exposure showed a negative and non-significant correlation with total protein (r = -0.098; p = 0.455), albumin (r = -0.097; p = 0.461), and total bilirubin (r = -0.156; p = 0.233). Conclusion The study suggests that occupational exposure to cement dust may pose a risk of developing hepatotoxicity in the future.

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Exposure-Time Effect of Cement Dust on Liver Organ in Rat (Rattus norvegicus)

Cited by 2 publications

References 8 publications

Investigating the Preventive and Therapeutic Role of Costus afer in Acetaminophen Induced Liver Toxicity

Investigating the Preventive and Therapeutic Role of Costus afer in Acetaminophen Induced Liver Toxicity

Investigation of Hepatotoxic Effect of Cement-Dust in Occupationally Exposed Individuals in North Central Nigeria

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