Exposure to a mycovirus containing Aspergillus Flavus reproduces acute lymphoblastic leukemia cell surface and genetic markers in cells from patients in remission and not controls

Tebbi, Cameron K.; Badiga, Aruna; Sahakian, Eva; Powers, John J.; Achille, Alex; Patel, Saumil; Migone, Felicia

doi:10.1016/j.ctarc.2020.100279

Cited by 10 publications

(12 citation statements)

References 45 publications

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“…Infections, including bacterial, viral and fungal agents alone, and in conjunction with genetic mutations, have been implicated in leukemogenesis. Infective agents have been suspected to be associated with the development of cancer in general and acute leukemias in particular [ 139 , 140 , 141 , 142 ]. However, save for some recent reports [ 141 , 142 ], no consistent agent which can be uniformly applied to a group of patients is available.…”

Section: Infectionsmentioning

confidence: 99%

“…Infective agents have been suspected to be associated with the development of cancer in general and acute leukemias in particular [ 139 , 140 , 141 , 142 ]. However, save for some recent reports [ 141 , 142 ], no consistent agent which can be uniformly applied to a group of patients is available. The impact of a variety of infectious organisms, including the Epstein–Barr virus (EBV), herpesvirus, human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), COVID-19 and Human T-lymphotropic virus (HTLV-1), among others, in the development of leukemia have been hypothesized and explored [ 99 , 139 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ].…”

Section: Infectionsmentioning

confidence: 99%

“…In recent reports, an Aspergillus Flavus species, isolated from the home of a patient with ALL by electron microscopy examination was found to contain a mycovirus within the body of the fungi and its culture supernatant [ 141 , 142 ]. This organism, by chemical analysis, was reported not to produce any aflatoxin.…”

Section: Infectionsmentioning

confidence: 99%

“…This study may indicate that mycovirus containing Aspergillus Flavus can directly affect cells of ALL patients in remission and alter and transform the genetic and cell surface makers of their presumably genetically susceptible cells, and not controls. The report also indicates that in limited studies, when cultures with and without EBV were irradiated, this had significantly increased the co-expression of CD10/CD19, which is considered as one of the characteristic cell surface phenotypes in the ALL [ 142 ]. Considering the two-hit theory for the development of acute lymphoblastic leukemia, it is postulated that the mycovirus containing Aspergillus Flavus may provide a consistent organism in the mechanism of leukemogenesis in acute lymphoblastic leukemia [ 141 ].…”

Section: Infectionsmentioning

confidence: 99%

“…While several genetic mutations have been suggested, no infection category or specific agent has been proposed. Recent reports suggest a mycovirus containing Aspergillus flavus as one of the possible candidates for the infection category [ 141 , 142 ].…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

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Etiology of Acute Leukemia: A Review

Tebbi¹

2021

Cancers

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Acute leukemias constitute some of the most common malignant disorders. Despite significant progress made in the treatment of these disorders, their etiology remains unknown. A large and diverse group of genetic and environmental variables have been proposed. The role of a variety of factors, including pre-existing and acquired genetic mutations, exposure to radiation and various chemicals during preconception, pregnancy and throughout life, have been explored. The effects of inherited genetic variations and disorders, pre-existing diseases, infectious agents, hobbies, occupations, prior treatments, and a host of other factors have been proposed, but none is universally applicable to all cases. Variation in the incidence and prognosis based on the age, sex, race, type of the disease, geographic area of residence and other factors are intriguing but remain unexplained. Advances in genomic profiling, including genome-wide gene expression, DNA copy number and single nucleotide polymorphism (SNP) genotype, may shed some light on the role of genetics in these disparities. Separate two-hit hypotheses for the development of acute myeloblastic and lymphoblastic leukemia have been proposed. The latter combines genetics and infection factors resulting in leukemogenesis. A number of pre- and post-natal environmental conditions and exposure to infections, including a mycovirus infected Aspergillus flavus, have been suggested. The exact nature, timing, sequence of the events and mechanisms resulting in the occurrence of leukemia requires further investigations. This review summarizes some of the above factors in acute lymphoblastic and myeloblastic leukemias and the direction for future research on the etiology of these disorders.

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Section: Infectionsmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

See 3 more Smart Citations

Etiology of Acute Leukemia: A Review

Tebbi¹

2021

Cancers

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Mycology in Oncology: Exploring the Role of the Mycobiome in Human Cancer, Etiology, Progression, Epidemiology, Mycoses, and Mycotoxins

Velez-Haro,

Pérez-Rodríguez,

Velázquez-Márquez

et al. 2024

Pathogens Associated With the Development of Cancer in Humans

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An Overview of Mycoviral Curing Strategies Used in Evaluating Fungal Host Fitness

2023

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The number of novel mycoviruses is increasing at a high pace due to advancements in sequencing technologies. As a result, an uncountable number of mycoviral sequences are available in public sequence repositories. However, only genomic information is not sufficient to understand the impact of mycoviruses on their host biology. Biological characterization is required to determine the nature of mycoviruses (cryptic, hypervirulent, or hypovirulent) and to search for mycoviruses with biocontrol and therapeutic potential. Currently, no particular selective method is used as the gold standard against these mycoviral infections. Given the importance of curing, we present an overview of procedures used in preparation of isogenic lines, along with their benefits and drawbacks. We concluded that a combination of single-spore isolation and hyphal tipping is the best fit for preparation of isogenic lines. Furthermore, recent bioinformatic approaches should be introduced in the field of mycovirology to predict virus-specific antivirals to get robust results. Graphical Abstract

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Exposure to a mycovirus containing Aspergillus Flavus reproduces acute lymphoblastic leukemia cell surface and genetic markers in cells from patients in remission and not controls

Cited by 10 publications

References 45 publications

Etiology of Acute Leukemia: A Review

Etiology of Acute Leukemia: A Review

Mycology in Oncology: Exploring the Role of the Mycobiome in Human Cancer, Etiology, Progression, Epidemiology, Mycoses, and Mycotoxins

An Overview of Mycoviral Curing Strategies Used in Evaluating Fungal Host Fitness

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