Exposure to air pollution and scarlet fever resurgence in China: a six-year surveillance study

Liu, Yonghong; Ding, Hui; Chang, Shu‐Ting; Lu, Ran; Zhong, Hui; Zhao, Na; Lin, Tzong-Shyan; Bào, Yīmíng; Yap, Li-Wei; Xu, Wei; Wang, Minyi; Li, Yuan; Qin, Shuwen; Zhao, Yu; Geng, Xin; Wang, Supen; Yu, Zhi; Chan, Ta‐Chien; Liu, Shelan

doi:10.1038/s41467-020-17987-8

Cited by 30 publications

(23 citation statements)

References 42 publications

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“…Liver injury triggers KC activation, leading to the release of inflammatory cytokines and chemokines, such as IL‐1β and TNF‐α (Tacke, 2017). KC‐derived IL‐1β increases hepatocyte NF‐κB signalling, which interferes with FXR and NR1H3 binding to the corresponding promoters of genes for canalicular bile transporters ( Abcc2 and Abcb11 ) and sterol transporters ( Abcg5/8 ), resulting in transcriptional suppression and subsequent cholestasis (Liu et al, 2020). Taken together, tectorigenin can indirectly protect liver parenchymal cells by inhibiting KC activation and KC‐derived IL‐1β.…”

Section: Discussionmentioning

confidence: 99%

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ

Xiang

Yang

et al. 2021

British J Pharmacology

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Background and Purpose: Increasing evidence suggests that human cholestasis is closely associated with the accumulation and activation of hepatic macrophages.Research indicates that activation of PPARγ exerts liver protective effects in cholestatic liver disease (CLD), particularly by ameliorating inflammation and fibrosis, thus limiting disease progression. However, existing PPARγ agonists, such as troglitazone and rosiglitazone, have significant side effects that prevent their clinical application in the treatment of CLD. In this study, we found that tectorigenin alleviates intrahepatic cholestasis in mice by activating PPARγ.Experimental Approach: Wild-type mice were intragastrically administered α-naphthylisothiocyanate (ANIT) or fed a diet containing 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) to simultaneously establish an experimental model of intrahepatic cholestasis and tectorigenin intervention, followed by determination of intrahepatic cholestasis and the mechanisms involved. In addition, PPARγ-deficient mice were administered ANIT and/or tectorigenin to determine whether tectorigenin exerts its liver protective effect by activating PPARγ.

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Section: Discussionmentioning

confidence: 99%

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ

Xiang

Yang

et al. 2021

British J Pharmacology

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“…NO 2 is mainly emitted into the air by burning fossil fuels, especially vehicle fuels. O 3 is formed by the interaction of nitrogen oxides (NOx) and volatile organic compounds (VOCs) with sunlight and it is also high positive correlation with vehicles exhaust emissions 35 . Using gasoline or diesel fuel cars and using carbon compounds in industrial processes are the major two responsibilities for CO being discharged to the atmosphere 36,37 .…”

Section: Description Of the General Conditionmentioning

confidence: 99%

Exposure to Ambient Air Pollutions and Upper Respiratory Tract Infection in Zhengzhou City, China: A Approximate Five-Year Surveillance Study

Shi¹,

He²,

Jia³

et al. 2021

Preprint

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Background: Studies indicated that air pollutions were associated with respiratory disease have with a lag exposure–response relationship, but not linear. However, few evidences in Zhengzhou, one of the most polluted cities for China.Method: Upper respiratory tract infection (URTI) outpatient visits in the hospital, meteorological parameters and air pollutions data were obtained from October 28, 2013 to May 1, 2018 and were used for evaluating the risk effects of the air pollutants with a distributed lag non-linear model (DLNM), including the stratified analysis of gender and age.Result: 475013 cases were included, with obvious seasonal fluctuations,higher in cool/cold and lower in warm. Every increase of 10μg/m3 of PM2.5, PM10, SO2, NO2 and CO showed similar impacts on URTI outpatient visits in different genders and age sub-groups,within 0 to15 days of lag. PM10, SO2 and NO2 had the strongest immediately risk at lag 0 [RRPM10: 1.0011, 95%CI (1.0002-1.0020); RRSO2: 1.0084, 95%CI (1.0039-1.0130); RRNO2: 1.0149, 95%CI: (1.0111-1.0188), respectively], while PM2.5 and CO got highest risk at lag 15 days [RRPM2.5: 1.0014, 95%CI (1.0003-1.0025); RRCO: 1.0002, 95%CI: (1.0001-1.0003), respectively]. In addition, calculating overall accumulated effects of each 10μg/m3 increase in PM10, SO2, NO2, and CO was greater in females than in males, as well as greater in the adolescents (aged 0-18 years) and elderly (aged ≥ 60 years) than in adults (aged 19-59 years), except CO was greater in the adolescents and adults than in the elderly. No significant cumulative effects were found in PM2.5. O3 levelwasno significant correlation withURTI outpatient visits throughout the lag period.Conclusions: Our results indicated that PM10, SO2, NO2 and CO had strong immediate and lag cumulative effects in the females, adolescents, and elderly. PM2.5 has lag effects but has no significant lag cumulative impact effects on gender and age.

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“…The Yangtze River Delta is one of the top five regions affected by COVID-19 in China, with 1835 and 1322 confirmed cases having been reported in Shanghai Province and Zhejiang Province, respectively, as of 16 March 2021, by local health commissions. The Yangtze River Delta is one of the most densely populated regions on earth and belongs to the more developed areas of China, with over 150 million registered residents.…”

Section: Introductionmentioning

confidence: 99%

“…In 2019, the WHO listed 10 environmental threats to global health; of these, air pollution was considered the greatest threat [16]. Previous studies have demonstrated a positive association between exposure to air pollution and the rate of RIDs [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Coronavirus 2019 Disease Control Measures on the Incidence of Respiratory Infectious Disease and Air Pollutant Concentrations in the Yangtze River Delta Region, China

Wang

Zhong

et al. 2022

IJERPH

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The Yangtze River Delta is one of the top five Chinese regions affected by COVID-19, as it is adjacent to Hubei Province, where COVID-19 first emerged. We investigated the impact of COVID-19 non-pharmaceutical interventions (NPIs) on changes in respiratory infectious diseases (RIDs) incidence and air quality in the Yangtze River Delta by constructing two proportional tests and fitting ARIMA and linear regression models. Compared with the pre-COVID-19 period, the average monthly incidence of seven RIDs decreased by 37.80% (p < 0.001) and 37.11% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 20.39% (p < 0.001) and 22.86% (p < 0.001), respectively, in Zhejiang. Similarly, compared with the pre-COVID-19 period, the monthly overall concentrations of six air pollutants decreased by 12.7% (p = 0.003) and 18.79% (p < 0.001) during the COVID-19 period and the post-vaccination period, respectively, in Shanghai, and decreased by 12.85% (p = 0.008) and 15.26% (p = 0.001), respectively, in Zhejiang. Interestingly, no significant difference in overall incidence of RIDs and concentrations of air quality was shown between the COVID-19 period and the post-vaccination period in either Shanghai or Zhejiang. This study provides additional evidence that the NPIs measures taken to control COVID-19 were effective in improving air quality and reducing the spread of RIDs. However, a direct causal relationship has not been established.

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Exposure to air pollution and scarlet fever resurgence in China: a six-year surveillance study

Cited by 30 publications

References 42 publications

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ

Exposure to Ambient Air Pollutions and Upper Respiratory Tract Infection in Zhengzhou City, China: A Approximate Five-Year Surveillance Study

The Effect of Coronavirus 2019 Disease Control Measures on the Incidence of Respiratory Infectious Disease and Air Pollutant Concentrations in the Yangtze River Delta Region, China

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