Exposure to air pollution and cognitive functioning across the life course – A systematic literature review

Clifford, Angela; Lang, Linda; Chen, Ruoling; Anstey, Kaarin J.; Seaton, Anthony

doi:10.1016/j.envres.2016.01.018

Cited by 382 publications

(231 citation statements)

References 65 publications

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“…Existing evidence from meta-analysis indicates an association between air pollutants and both T2DM [75] and cognitive decline [78]. The studies that examined neurodegeneration-related outcomes mostly reported positive associations of particulate air pollution exposure and only three studies found no association [49,51,79].…”

Section: Resultsmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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It has been hypothesised that environmental air pollution, especially airborne particles, is a risk factor for type 2 diabetes mellitus (T2DM) and neurodegenerative conditions. However, epidemiological evidence is inconsistent and has not been previously evaluated as part of a systematic review. Our objectives were to carry out a systematic review of the epidemiological evidence on the association between long-term exposure to ambient air pollution and T2DM and neurodegenerative diseases in adults and to identify if workplace exposures to particles are associated with an increased risk of T2DM and neurodegenerative diseases. Assessment of the quality of the evidence was carried out using the GRADE system, which considers the quality of the studies, consistency, directness, effect size, and publication bias. Available evidence indicates a consistent positive association between ambient air pollution and both T2DM and neurodegeneration risk, such as dementia and a general decline in cognition. However, corresponding evidence for workplace exposures are lacking. Further research is required to identify the link and mechanisms associated with particulate exposure and disease pathogenesis and to investigate the risks in occupational populations. Additional steps are needed to reduce air pollution levels and possibly also in the workplace environment to decrease the incidence of T2DM and cognitive decline.

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Section: Resultsmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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“…Instead, the cognitive/ behavioral studies tended to focus on environmental contaminants with known neurotoxic effects (e.g., lead, PCBs). While focusing on traditional neurotoxic exposures is logical, the omission of air quality was surprising given the associations between air pollution and neurodevelopmental outcomes across childhood [70], including recent evidence linking prenatal exposure to air pollution with autism risk [71,72]. Moreover, it is well understood that poor air quality is socially patterned with the most vulnerable families being particularly at risk [73].…”

Section: Gaps In Environmental Exposures Assessed By Outcomementioning

confidence: 96%

A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Appleton

Holdsworth

Kubzansky

2016

Curr Envir Health Rpt

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Forty-one studies met the search criteria and were reviewed. Of these, 37, 34, and 29 % of studies focused on asthma, cognition/behavior, and perinatal outcomes, respectively. No study focused on obesity. Across all studies reviewed, 72 % observed significant synergistic associations between social and environmental exposures. Air pollution was the most frequently studied environmental exposure, and socioeconomic status was the most commonly studied social factor. The emerging evidence suggests that social and environmental risks may jointly affect child health. Recommendations for future research are discussed, including enhancing characterization of the social environment and broadening the types of environmental risks assessed.

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“…Air pollution exposure results in low birth weight, 20 poor lung development in children, 21 mortality from respiratory infections, 22 and may also affect cognitive development. 23 Older people are more likely to develop chronic respiratory and cardiac illnesses, and are more susceptible to heart attacks and strokes from long term exposure, and during episodic high pollution events. 24 Lower socioeconomic groups are more susceptible to insults from air pollution exposure for a variety of reasons including occupation and housing.…”

Section: Impact On Healthmentioning

confidence: 99%

Tackling the health burden of air pollution in South Asia

Krishna

Balakrishnan

Siddiqui

et al. 2017

BMJ

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Exposure to air pollution and cognitive functioning across the life course – A systematic literature review

Cited by 382 publications

References 65 publications

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

A Systematic Review of the Interplay Between Social Determinants and Environmental Exposures for Early-Life Outcomes

Tackling the health burden of air pollution in South Asia

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