Exposure to air pollution and risk of respiratory tract infections in the adult Danish population—a nationwide study

Kaspersen, Kathrine A.; Antonsen, Sussie; Horsdal, Henriette T.; Kjerulff, Bertram; Brandt, Jørgen; Geels, Camilla; Christensen, Jesper H.; Frohn, Lise M.; Sabel, Clive E.; Dinh, Khoa M.; Hertel, Ole; Sigsgaard, Torben; Pedersen, Carsten B.; Erikstrup, Christian

doi:10.1016/j.cmi.2023.10.013

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…PM10 can penetrate deeper into the lungs, targeting the lung bronchioles and resulting in remodeling of lung tissue and the upregulation of immune cells [140]. Damage to lung architecture and altered immune response elevate the likelihood of lung diseases such as chronic obstructive pulmonary disease (COPD), chronic bronchitis, and respiratory tract infections due to resulting lung impairment and dysfunction post-exposure to environmental toxins [43,141,142].…”

Section: Environmental Toxins and Immune Response In The Lungsmentioning

confidence: 99%

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Ruggles,

Benakis

2024

Cells

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Recent evidence suggests that exposure to environmental toxins, both short-term and long-term, can increase the risk of developing neurological disorders, including neurodegenerative diseases (i.e., Alzheimer’s disease and other dementias) and acute brain injury (i.e., stroke). For stroke, the latest systematic analysis revealed that exposure to ambient particulate matter is the second most frequent stroke risk after high blood pressure. However, preclinical and clinical stroke investigations on the deleterious consequences of environmental pollutants are scarce. This review examines recent evidence of how environmental toxins, absorbed along the digestive tract or inhaled through the lungs, affect the host cellular response. We particularly address the consequences of environmental toxins on the immune response and the microbiome at the gut and lung barrier sites. Additionally, this review highlights findings showing the potential contribution of environmental toxins to an increased risk of stroke. A better understanding of the biological mechanisms underlying exposure to environmental toxins has the potential to mitigate stroke risk and other neurological disorders.

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Section: Environmental Toxins and Immune Response In The Lungsmentioning

confidence: 99%

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Ruggles,

Benakis

2024

Cells

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Exploring the Relationship between Acute Coronary Syndrome, Lower Respiratory Tract Infections, and Atmospheric Pollution

Muszyński,

Pawluczuk,

Januszko

et al. 2024

JCM

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Background: Respiratory infections were found to be connected with the incidence of acute coronary syndrome (ACS). The proposed pathway of this connection includes inflammation, oxidative stress, pro-coagulation, and atherosclerotic plaque destabilization. This can cause rapture and thrombus formation, leading to ACS. Our study aimed to assess the risk factors for coronary artery thrombosis as a manifestation of ACS and for lower respiratory tract infections (LRTIs) in patients with ACS. Methods: The study included 876 patients with ACS from January 2014 to December 2018. Both the clinical data and air pollution data were analyzed. Statistical tests used for analysis included Student’s t-test, the Mann–Whitney U-test, the Chi-squared test, and the odds ratio Altman calculation. Results: LRTIs were found in 9.13% patients with ACS. The patients with LRTI had a higher risk of coronary artery thrombosis (OR: 2.4903; CI: 1.3483 to 4.5996). Moreover, they had increased values of inflammatory markers, were older, had a lower BMI, and a higher rate of atrial fibrillation. The average atmospheric aerosols with a maximum diameter of 2.5 μm (PM2.5 concentration) from three consecutive days before hospitalization for ACS were higher in patients with LRTI. Conclusions: The occurrence of coronary artery thrombosis was higher among the patients with LRTI during ACS. PM2.5 exposition was higher in the three consecutive days before hospitalization in patients with LRTI during ACS.

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Exposure to air pollution and risk of respiratory tract infections in the adult Danish population—a nationwide study

Cited by 2 publications

References 27 publications

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Exposure to Environmental Toxins: Potential Implications for Stroke Risk via the Gut– and Lung–Brain Axis

Exploring the Relationship between Acute Coronary Syndrome, Lower Respiratory Tract Infections, and Atmospheric Pollution

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