Exposure to airborne particulate matter induces renal tubular cell injury in vitro: the role of vitamin D signaling and renin-angiotensin system

Kang, Eungu; Yim, Hyung Eun; Nam, Yoon Jeong; Jeong, Sang Hoon; Kim, Joo-Ae; Lee, Ju Han; Son, Min Hwa; Yoo, Kee Hwan

doi:10.1016/j.heliyon.2022.e10184

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…The PM sample used in this study was collected on the day with an ambient PM 2.5 concentration of 38 μg/m 3 . The levels of water-soluble organic carbon and inorganic ions in the PM suspension were similar to those described in our previous report [19]. NO 3 − was the most abundant ion, followed by NH 4 + , organic carbon, Na + , SO 4…”

Section: Characteristics Of Particulate Mattersupporting

confidence: 88%

“…Our previous in vitro study [19] demonstrated that PM 2.5 exposure reduced VDR expression in human proximal renal tubular cells and increased the activities of CYP27B1, renin, ACE, and AT1R. Vitamin D analog reversed the RAS activation, while it restored VDR expression and reduced CYP27B1 activity.…”

Section: Discussionmentioning

confidence: 92%

“…Airborne fine PM samples were collected as described in our previous experiment [19]. Two filters (QR-100; Sibata) on the same day (December 22, 2019) above the World Health Organization guidelines for PM 2.5 (average of ≥25 μg/m 3 per day) were chosen for the experiment.…”

Section: Particulate Matter Collection Analysis and Preparationmentioning

confidence: 99%

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Maternal exposure to airborne particulate matter during pregnancy and lactation induces kidney injury in rat dams and their male offspring: the role of vitamin D in pregnancy and beyond

Son,

Park,

Yim

et al. 2024

Kidney Res Clin Pract

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Background: Little is known about the transgenerational effects of maternal exposure to fine particulate matter (PM 2.5 ) on offspring kidney health. This study investigated the effect of maternal administration of PM 2.5 or PM 2.5 with vitamin D during pregnancy and lactation on renal injury in rat dams and their offspring. Methods: Nine pregnant Sprague-Dawley rats received oral administration of normal saline, airborne PM 2.5 , or PM 2.5 with vitamin D from gestational day 11 to postpartum day 21. Kidneys of rat dams (n = 3 for each group) and their male offspring (n = 5 for each group) were taken for analysis on postpartum or postnatal day 21. Results: Maternal PM 2.5 exposure increased glomerular damage, tubulointerstitial injury, and cortical macrophage infiltration in both dams and pups; all increases were attenuated by vitamin D administration. In dam kidneys, PM 2.5 increased the protein expression of vitamin D receptor (VDR), klotho, and tumor necrosis factor-α; vitamin D lessened these changes. The expressions of renin, nuclear factor erythroid 2-related factor 2 (Nrf2), and nuclear factor-kappa B (NF-κB) p50 decreased in rat dams exposed to PM 2.5 . In offspring kidneys, exposure to maternal PM 2.5 reduced the expression of VDR, renin, angiotensin-converting enzyme (ACE), Nrf2, and NF-κB p50, but increased cytochrome P450 24A1 expression. Maternal vitamin D administration with PM 2.5 enhanced VDR, ACE, and NF-κB p50 activities in pup kidneys. Conclusion: PM 2.5 exposure during nephrogenesis may exert transgenerational renal impairment, and maternal vitamin D intake could attenuate PM 2.5 -induced kidney damage in mothers and their offspring.

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Section: Characteristics Of Particulate Mattersupporting

confidence: 88%

Section: Discussionmentioning

confidence: 92%