Exposure to Allergen-Specific Immunotherapy in Pregnancy and Risk of Congenital Malformations and Other Adverse Pregnancy Outcomes

Mitselou, Niki; Stephansson, Olof; Ludvigsson, Jonas F.

doi:10.1016/j.jaip.2022.03.005

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In actuality, there are still limited data about the response of the offspring in pregnancies exposed to AIT. A recent study on a Swedish cohort of pregnancies exposed to both SCIT and SLIT found no elevated risk for congenital malformations or other adverse outcomes [ 37 ]. Moreover, the initiation of AIT during pregnancy has also been reported to be safe, both in a retrospective study for SCIT [ 38 ] and in a prospective study for SLIT [ 39 ], though it is necessary to point out the limited number of cases considered.…”

Section: Main Reported Causes Of Dropoutsmentioning

confidence: 99%

Causes of Non-Adherence to Allergen-Specific Immunotherapy: A Foundation towards a Patient-Personalized Approach

Ridolo,

Nicoletta,

Barone

et al. 2023

JPM

View full text Add to dashboard Cite

Background. Allergen-specific immunotherapy (AIT) is the only disease-modifying therapy for allergic conditions, resulting in a long-lasting tolerance beyond the duration of the treatment. Due to the strong relationship between the effectiveness, its optimal duration (at least three years) and the observation of the correct administration protocol, appropriate adherence to the plan of treatment represents a critical factor for the therapeutical success of AIT. Methods. Analysis of studies about the rate of adherence in subcutaneous and sublingual immunotherapy, which are the main routes of administration of AIT. Results. There are different causes leading to a premature interruption of the therapy or to it being incorrectly carried out; the most reported include erroneous expectations of the effectiveness and the adverse effects, economic issues, inconvenience and unrelated clinical conditions. Conclusions. An attentive analysis of the main causes of dropouts may be useful to improve the management of these patients and to develop new strategies for a personalized approach. These strategies should be dynamic, involving attentive communication between the physician and the patient about all the possible criticalities, especially in the initial phase of the therapy, and facilitating, as much as possible, access to healthcare providers over the course of the maintenance phase, including by exploiting technological tools.

show abstract

Section: Main Reported Causes Of Dropoutsmentioning

confidence: 99%