Exposure to Aluminum in Daily Life and Alzheimer’s Disease

Nie, Jing

doi:10.1007/978-981-13-1370-7_6

Cited by 36 publications

(14 citation statements)

References 34 publications

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“…In the past, neurotoxic effects of aluminium were frequently associated with Alzheimer's disease (AD) (Inan-Eroglu and Ayaz 2018; Lukiw et al 2019;Nie 2018), a disorder characterised by the accumulation of pathological amyloid deposits in the brain. These deposits are believed to originate from the conversion of membrane proteins as a result of the destruction of nerve cells or cell membranes, a phenomenon that increases with age.…”

Section: Neurotoxicitymentioning

confidence: 99%

Aggregated aluminium exposure: risk assessment for the general population

et al. 2019

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Aluminium is one of the most abundant elements in earth's crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials (FCM), and cosmetic products. For the estimation of aluminium contents in foodstuff, data from the German "Pilot-Total-Diet-Study" were used, which was conducted as part of the European TDS-Exposure project. These were combined with consumption data from the German National Consumption Survey II to yield aluminium exposure via food for adults. It was found that the average weekly aluminium exposure resulting from food intake amounts to approx. 50% of the tolerable weekly intake (TWI) of 1 mg/kg body weight (bw)/week, derived by the European Food Safety Authority (EFSA). For children, data from the French "Infant Total Diet Study" and the "Second French Total Diet Study" were used to estimate aluminium exposure via food. As a result, the TWI can be exhausted or slightly exceeded-particularly for infants who are not exclusively breastfed and young children relying on specially adapted diets (e.g. soy-based, lactose free, hypoallergenic). When taking into account the overall aluminium exposure from foods, cosmetic products (cosmetics), pharmaceuticals and FCM from uncoated aluminium, a significant exceedance of the EFSA-derived TWI and even the PTWI of 2 mg/kg bw/week, derived by the Joint FAO/WHO Expert Committee on Food Additives, may occur. Specifically, high exposure levels were found for adolescents aged 11-14 years. Although exposure data were collected with special regard to the German population, it is also representative for European and comparable to international consumers. From a toxicological point of view, regular exceedance of the lifetime tolerable aluminium intake (TWI/PTWI) is undesirable, since this results in an increased risk for health impairments. Consequently, recommendations on how to reduce overall aluminium exposure are given. Article Highlights • Risk assessment of total aluminium exposure from different sources for different age groups. • Use of data from the European TDS-Exposure project for the estimation of aluminium exposure from foodstuff. • Comprehensive overview of the toxicological properties of aluminium.

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Section: Neurotoxicitymentioning

confidence: 99%

Aggregated aluminium exposure: risk assessment for the general population

et al. 2019

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“…Air and water pollutants can specifically influence brain tissue and cause memory impairment, which, in turn, can lead to AD or other neurodegenerative disorders. Among the heavy metals, aluminum has shown harmful effects on memory and learning via induction of oxidative stress, Aβ decomposition in brain tissue, neural cell death, and AD-like symptoms ( McLachlan, 1986 ; Nie, 2018 ; D’Haese et al, 2019 ; Goher et al, 2019 ; Huat et al, 2019 ; Butterfield and Mattson, 2020 ; Van Dyke et al, 2020 ). Quercetin is known as an antioxidant with high ROS scavenger activity ( Carmona-Aparicio et al, 2019 ; Ezequiel et al, 2019 ; Taïlé et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

et al. 2021

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Alzheimer’s disease (AD) is a neurodegenerative disease with cognitive impairment. Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailability. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. In this study, male Wistar rats were subjected to AlCl3, AlCl3 + QT, AlCl3 + SPION, and AlCl3 + QT-SPION for 42 consecutive days. Behavioral tests and qPCR were used to evaluate the efficiency of treatments. Results of behavioral tests revealed that the intensity of cognitive impairment was decelerated at both the middle and end of the treatment period. The effect of QT-SPIONs on learning and memory deficits were closely similar to the control group. The increase in expression levels of APP gene and the decrease in mir101 led to the development of AD symptoms in rats treated with AlCl3 while these results were reversed in the AlCl3 + QT-SPIONs group. This group showed similar results with the control group. QT-SPION also decreased the expression levels of antioxidant enzymes along with increases in expression levels of anti-apoptotic genes. Accordingly, the antioxidant effect of QT-SPION inhibited progression of cognitive impairment via sustaining the balance of antioxidant enzymes in the hippocampus of AD model rats.

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“…reservoirs and subsequently in water table. In surface water, concentration of Al is usually less than 0.1mg/L; but decrease in pH of the water reservoir enhances Al solubility, leading to increase in Al concentration 2 . This ultimately leads to the entry of Al in food chain and ultimately to humans, as we are the tertiary/ultimate consumers.…”

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confidence: 99%

“…These comprise firming agents in pickles, emulsifying agents in processed cheese, baking powder and many food colourings 4 . Some products of daily use like tea, toothpaste and infant formulas have been reported to contain Al ( Figure 1) 5,2 . The concentration of Al in food items is variable 5 .…”

mentioning

confidence: 99%

“…In experimental animals, Al showed negative effects on the reproductive and nervous system that's why in 2007 the Provisional Tolerable Weekly Intake (PTWI) of Al was decreased from 7 mg/ kg body weight to 1 mg/kg body weight. However, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) amended the PTWI to 2 mg/kg body weight in 2011, consequent of new bioavailability and toxicological data 2 .…”

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confidence: 99%

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Aluminium and Neuro-degeneration: Mechanism of pathogenesis and possible strategies for mitigation

Bhargava

Netam

Singh

et al. 2021

Asian Journal of Pharmaceutical Research and Health Care

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One of the most abundant metal in our environment is aluminium (Al). Occupational exposure of humans to Al takes place during its extractions, processing and fabrications of articles of daily use. Al in drinking water and as well as its use in packaging & storage of food is also a potential source of exposure. Acute exposure of higher concentration or chronic exposure of low concentration of Al leads to its aggregation in various parts of the body, resulting in system toxicity. Brain is highly susceptible to Al accumulation toxicity. In humans, exposure of Al is a risk factor for the starting of Alzheimer Disease. The adverse effect of Al exposure on nervous system results in memory loss, balance problems and impairment of coordination. High level of Al in brain increases lipid peroxidation and oxidative stress and reduces antioxidant enzymes level. It also causes aggregation of amyloid beta proteins and formation of Neurofibrillary Tangles (NFTs) of tau proteins which finally leads to death of neuronal cell and neurotoxicity. Metabolism and excretion of heavy metals including Al is very difficult and its leads to accumulation. The chelation therapy has been proposed where the organic molecules like EDTA, Chlorogenic acid and GSH binds with the heavy metals and facilitates for their excretion from body. However, non-specific binding of these chelators is another major safety concern. Medicinal plants and their phytochemicals with multiple mechanism of action have been proposed as a very good alternative for ameliorating heavy metal induced toxicity. In addition to mild chelating activities, the phytochemicals have antioxidant, anti-inflammatory, cytokine modulatory and other specific actions for proving holistic neuro-protection on heavy metal exposure.

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Exposure to Aluminum in Daily Life and Alzheimer’s Disease

Cited by 36 publications

References 34 publications

Aggregated aluminium exposure: risk assessment for the general population

Aggregated aluminium exposure: risk assessment for the general population

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

Aluminium and Neuro-degeneration: Mechanism of pathogenesis and possible strategies for mitigation

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