Exposure to ambient air pollutants and spontaneous abortion

Moridi, Maryam; Ziaei, Saeideh; Kazemnejad, Anoshirvan

doi:10.1111/jog.12231

Cited by 36 publications

(27 citation statements)

References 43 publications

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“…The authors found a correlation of 80–90%, depending on the pollutant in consideration. Moridi et al (2014) investigated the association between spontaneous abortion and ambient pollutants. The authors estimated the mean exposure to pollution for each of 296 women in Iran.…”

Section: Discussionmentioning

confidence: 99%

Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo, Uruguay

Balsa

Caffera

Bloomfield

2016

Environ Health Perspect

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Background:The ashes and dust resulting from the 2011 eruptions of the Puyehue volcano in Chile more than doubled monthly averages of PM10 concentrations in Montevideo, Uruguay. Few studies have taken advantage of natural experiments to assess the relationship between ambient air pollutant concentrations and birth outcomes.Objectives:In this study we explored the effect of particulate matter with diameter of ≤ 10 μm (PM10) on perinatal outcomes in Uruguay, a middle-income country in South America with levels of PM10 that in general do not exceed the recommended thresholds. The analyzed outcomes are preterm birth, term birth weight, and term low birth weight.Methods:We took advantage of the sharp variation in PM10 concentrations due to the Puyehue eruptions to estimate the associations between mother’s exposure to PM10 in each trimester of pregnancy and perinatal outcomes. We use birth registries for 2010–2013 and control for covariates, including maternal and pregnancy characteristics, weather, co-pollutants, and calendar quarter and hospital indicators.Results:A 10-μg/m3 increase in exposure to PM10 during the third trimester was associated with a higher likelihood of a preterm birth [odds ratio (OR) = 1.10; 95% CI: 1.03, 1.19]. The association was robust to different model specifications, and increased with categorical exposure levels (OR for third-trimester PM10 ≥ 70 vs. < 30 μg/m3 = 5.24; 95% CI: 3.40, 8.08). Exposures were not consistently associated with birth weight or low birth weight among term births, though second-trimester exposures were associated with higher birth weight, contrary to expectations.Conclusions:Taking advantage of a natural experiment, we found evidence that exposure to high levels of PM10 during the third trimester of pregnancy may have increased preterm births among women in Montevideo, Uruguay.Citation:Balsa AI, Caffera M, Bloomfield J. 2016. Exposures to particulate matter from the eruptions of the Puyehue Volcano and birth outcomes in Montevideo, Uruguay. Environ Health Perspect 124:1816–1822; http://dx.doi.org/10.1289/EHP235

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Section: Discussionmentioning

confidence: 99%

Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo, Uruguay

Balsa

Caffera

Bloomfield

2016

Environ Health Perspect

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“…These levels of CO may interfere with tissue oxygenation levels in the fetus, possibly leading to fetal death, as has been demonstrated in animal models [34]. A recent retrospective case control study in Tehran demonstrated that CO was more toxic with respect to spontaneous abortion than other pollutants, while no significant effect was identified for SO 2 [24]. In contrast, other studies have concluded that exposure to high levels of SO 2 and total suspended particulate (TSP) but not PM 10 and NO 2 during the first month of pregnancy was associated with increased risk of fetal loss [23].…”

Section: Discussionmentioning

confidence: 99%

“…One retrospective epidemiological study provided evidence for an association between brief exposure to high levels of ambient particulate matter during the preconceptional period and early pregnancy loss and found a 2.6-fold increased risk of spontaneous miscarriage [22]. More recent investigations in China [23] and Iran [24] also reported an increased risk of fetal loss in early pregnancy during exposure to high levels of air pollutants. However, no report has yet addressed associations between ambient air pollution and pregnancy loss in Mongolia.…”

Section: Introductionmentioning

confidence: 99%

Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia

Enkhmaa

Warburton

Javzandulam

et al. 2014

BMC Pregnancy Childbirth

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BackgroundAir pollution is a major health challenge worldwide and has previously been strongly associated with adverse reproductive health. This study aimed to examine the association between spontaneous abortion and seasonal variation of air pollutants in Ulaanbaatar, Mongolia.MethodsMonthly average O3, SO2, NO2, CO, PM10 and PM2.5 levels were measured at Mongolian Government Air Quality Monitoring stations. The medical records of 1219 women admitted to the hospital due to spontaneous abortion between 2009–2011 were examined retrospectively. Fetal deaths per calendar month from January-December, 2011 were counted and correlated with mean monthly levels of various air pollutants by means of regression analysis.ResultsRegression of ambient pollutants against fetal death as a dose–response toxicity curve revealed very strong dose–response correlations for SO2 r > 0.9 (p < 0.001) while similarly strongly significant correlation coefficients were found for NO2 (r > 0.8), CO (r > 0.9), PM10 (r > 0.9) and PM2.5 (r > 0.8), (p < 0.001), indicating a strong correlation between air pollution and decreased fetal wellbeing.ConclusionThe present study identified alarmingly strong statistical correlations between ambient air pollutants and spontaneous abortion. Further studies need to be done to examine possible correlations between personal exposure to air pollutants and pregnancy loss.

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“…Aside from respiratory problems, analyzing hospital admission and diagnoses in Iran also showed that air pollutants had a high correlation with acute strokes; and that long-term increases of PM 2.5 were related to ischemic strokes (Alimohammadi et al 2015). A study looking at around 300 women in Tehran, and evaluating the correlation between ambient air pollution and spontaneous abortions in the first-trimester, found that there is also heightened risk of spontaneous abortion associated with increased PM levels (Moridi et al 2014). A study in Isfahan, Iran showed how PM air pollution leads to hospitalization for respiratory diseases among children (Mansourian et al 2010).…”

Section: Morbiditymentioning

confidence: 99%

Air Pollution in Tehran

Heger¹,

Sarraf²

2018

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Exposure to ambient air pollutants and spontaneous abortion

Abstract: Our findings suggest that pregnant women exposed to ambient air pollutants may be at increased risk of spontaneous abortion. Confirmation by further research is needed.

Cited by 36 publications

References 43 publications

Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo, Uruguay

Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo, Uruguay

Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia

Air Pollution in Tehran

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