Exposure to ambient air pollution and calcification of the mitral annulus and aortic valve: the multi-ethnic study of atherosclerosis (MESA)

Tibuakuu, Martin; Jones, Miranda R.; Navas‐Acien, Ana; Zhao, Di; Güallar, Eliseo; Gassett, Amanda; Sheppard, Lianne; Budoff, Matthew J.; Kaufman, Joel D.; Michos, Erin D.

doi:10.1186/s12940-017-0346-x

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…Consistent with the findings of a multiethnic study, 40 we found an ambiguous association between PM 2.5 and valvular heart disease, suggesting that PM 2.5 might play a less important role than other primary risk factors such as genetics, infections, and other cardiovascular conditions. 41 The ambiguous association could also result from data variability.…”

Section: Discussionsupporting

confidence: 90%

Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study

Wei,

Feng,

Danesh Yazdi

et al. 2024

BMJ

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ObjectiveTo estimate exposure-response associations between chronic exposure to fine particulate matter (PM2.5) and risks of the first hospital admission for major cardiovascular disease (CVD) subtypes.DesignPopulation based cohort study.SettingContiguous US.Participants59 761 494 Medicare fee-for-service beneficiaries aged ≥65 years during 2000-16. Calibrated PM2.5predictions were linked to each participant’s residential zip code as proxy exposure measurements.Main outcome measuresRisk of the first hospital admission during follow-up for ischemic heart disease, cerebrovascular disease, heart failure, cardiomyopathy, arrhythmia, valvular heart disease, thoracic and abdominal aortic aneurysms, or a composite of these CVD subtypes. A causal framework robust against confounding bias and bias arising from errors in exposure measurements was developed for exposure-response estimations.ResultsThree year average PM2.5exposure was associated with increased relative risks of first hospital admissions for ischemic heart disease, cerebrovascular disease, heart failure, cardiomyopathy, arrhythmia, and thoracic and abdominal aortic aneurysms. For composite CVD, the exposure-response curve showed monotonically increased risk associated with PM2.5: compared with exposures ≤5 µg/m3(the World Health Organization air quality guideline), the relative risk at exposures between 9 and 10 µg/m3, which encompassed the US national average of 9.7 µg/m3during the study period, was 1.29 (95% confidence interval 1.28 to 1.30). On an absolute scale, the risk of hospital admission for composite CVD increased from 2.59% with exposures ≤5 µg/m3to 3.35% at exposures between 9 and 10 µg/m3. The effects persisted for at least three years after exposure to PM2.5. Age, education, accessibility to healthcare, and neighborhood deprivation level appeared to modify susceptibility to PM2.5.ConclusionsThe findings of this study suggest that no safe threshold exists for the chronic effect of PM2.5on overall cardiovascular health. Substantial benefits could be attained through adherence to the WHO air quality guideline.

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Section: Discussionsupporting

confidence: 90%

Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study

Wei,

Feng,

Danesh Yazdi

et al. 2024

BMJ

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“…4,[6][7][8] In this connection, several groups of investigators have reported that there is a strong link between adverse health outcomes including mortality and hospitalization and exposure to air pollution. [9][10][11] Air pollution exposure during pregnancy is a potential health threat to the unborn child as the pollutants might pass through placenta and affect the developing foetus. 12,13 Previous studies suggested that exposure to air pollution during pregnancy was linked to behavioural and neuroanatomical abnormalities in the offspring, including impaired intellectual ability, reduction of brain white matter and increased risk of attention deficit/hyperactivity disorder.…”

Section: Introductionmentioning

confidence: 99%

“…Pollutants of air pollution also include gaseous substances, namely ozone, nitrogen oxides and sulphur dioxide . In this connection, several groups of investigators have reported that there is a strong link between adverse health outcomes including mortality and hospitalization and exposure to air pollution . Air pollution exposure during pregnancy is a potential health threat to the unborn child as the pollutants might pass through placenta and affect the developing foetus .…”

Section: Introductionmentioning

confidence: 99%

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

Zheng

et al. 2019

J Cellular Molecular Medi

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Air pollution has been a serious public health issue over the past few decades particularly in developing countries. Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non‐coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution‐exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up‐regulated and 338 down‐regulated) were significantly differentially expressed in the air pollution‐exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G‐protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution‐exposed congenital spinal malformation.

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“…Air quality and exposures are important environmental contributors that affect both the morbidity and mortality of the population. 2,3 Studies have focused on the effect of air quality on outcomes such as asthma, 4,5 atherosclerosis, 6,7 obesity, 8 metabolic syndromes 9,10 and other cardiopulmonary disorders. According to the WHO, 4.2 million premature deaths worldwide per year are attributed to air quality and pollution.…”

Section: Introductionmentioning

confidence: 99%

Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review

Hall

Robinson

2019

JBI Database of Systematic Reviews and Implementation Reports

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Objective: The objective of this review was to determine if there was an association between maternal exposure to pollutant particulate matter 2.5 during the first trimester of pregnancy and congenital heart defects within the first year of life. Introduction: The environment is recognized as an important determinant of health for both the individual and population. Air pollution specifically is a major environmental risk factor impacting health with links to asthma, heart disease, obesity, and fetal developmental complications. Of the commonly monitored air pollutants, particulate matter 2.5 has associations with health, especially among vulnerable populations such as children and pregnant women. A congenital heart defect is a fetal complication that impacts 34.3 million infants globally, with more than 80% of the diagnoses having an unknown etiology. Although environmental risk factors such as air pollution are thought to be a risk factor in the diagnosis of a congenital heart defect, epidemiologic research evidence is limited. Inclusion criteria: This review considered studies that evaluated maternal exposure to the air pollutant particulate matter 2.5 during the first trimester (weeks 1–12) of fetal development. The primary outcome was a diagnosis of a congenital heart defect in an infant within the first year of life. Methods: A three-step search strategy was utilized in this review and included 11 databases and two websites. Studies published from January 2002 to September 2018 were eligible for inclusion. Only papers published in English were included. Eligible studies underwent critical appraisal by two independent reviewers using standardized critical appraisal instruments from JBI. Quantitative data were extracted from the included studies independently by two reviewers. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted for the individual outcome measures, specifically atrial septal defect, ventricular septal defect, and tetralogy of fallot, respectively. The defects were identified and pooled, where possible, in statistical meta-analysis. Where statistical pooling was not possible, findings were reported narratively. Results: Five studies were identified that met the inclusion criteria, including three cohort and two case-control designs. Each individual study identified at least one statistically significant increase or inverse association between particulate matter 2.5 and a congenital heart defect. An increased risk was identified with more than seven isolated and two groupings of congenital heart defects. An inverse risk was identified with two isolated and one grouping of congenital heart defects. Meta-analysis results were: atrial septal defect, OR = 0.65 (95% CI, 0.37 to 1.15); ventricular septal defect, OR 1.02 (95% CI, 075 to 1.37); and tetralogy of fallot, OR = 1.16 (95% CI, 0.78 to 1.73), indicating no statistically significant findings. Conclusion: There was no significant evidence to support an association between air pollutant particulate matter2.5 and a conge...

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Exposure to ambient air pollution and calcification of the mitral annulus and aortic valve: the multi-ethnic study of atherosclerosis (MESA)

Cited by 12 publications

References 33 publications

Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study

Exposure-response associations between chronic exposure to fine particulate matter and risks of hospital admission for major cardiovascular diseases: population based cohort study

Aberrantly expressed long non‐coding RNAs in air pollution‐induced congenital defects

Association between maternal exposure to pollutant particulate matter 2.5 and congenital heart defects: a systematic review

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