Exposure to Arsenic Alters the Microbiome of Larval Zebrafish

Dahan, Dylan; Jude, Brooke A.; Lamendella, Regina; Keesing, Felicia; Perron, Gabriel G.

doi:10.3389/fmicb.2018.01323

Cited by 52 publications

(39 citation statements)

References 88 publications

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“…In the functional context, a pioneering rumenbased study found fermentation rates were inhibited~30% by the addition of~30 μM As(III) to rumen microflora enrichments; levels of As(III) required to inhibit fermentation were less than that toxic to the animal itself (Forsberg, 1978). In a phylogenetic context, studies examining insects, fish, rodents and ruminants (Schramm et al, 2003;Pass et al, 2015;Dahan et al, 2018;Gaulke et al, 2018;Liu et al, 2018;Xue et al, 2019b) are congruent in illustrating that arsenic alters the microbiome community composition. Changes corresponded to increases in Bacteroidetes and decreases of Firmicutes.…”

Section: Arsenic Perturbation Of the Microbiomementioning

confidence: 99%

Arsenic and the gastrointestinal tract microbiome

McDermott

Stolz

Oremland

2020

Environ Microbiol Rep

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Summary Arsenic is a toxin, ranking first on the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency Priority List of Hazardous Substances. Chronic exposure increases the risk of a broad range of human illnesses, most notably cancer; however, there is significant variability in arsenic‐induced disease among exposed individuals. Human genetics is a known component, but it alone cannot account for the large inter‐individual variability in the presentation of arsenicosis symptoms. Each part of the gastrointestinal tract (GIT) may be considered as a unique environment with characteristic pH, oxygen concentration, and microbiome. Given the well‐established arsenic redox transformation activities of microorganisms, it is reasonable to imagine how the GIT microbiome composition variability among individuals could play a significant role in determining the fate, mobility and toxicity of arsenic, whether inhaled or ingested. This is a relatively new field of research that would benefit from early dialogue aimed at summarizing what is known and identifying reasonable research targets and concepts. Herein, we strive to initiate this dialogue by reviewing known aspects of microbe–arsenic interactions and placing it in the context of potential for influencing host exposure and health risks. We finish by considering future experimental approaches that might be of value.

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Section: Arsenic Perturbation Of the Microbiomementioning

confidence: 99%

Arsenic and the gastrointestinal tract microbiome

McDermott

Stolz

Oremland

2020

Environ Microbiol Rep

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“…This protocol revealed that 131 I-PEG-AuNRs are extraordinary stable in vivo condition. In a recent work, cyclic arginine-glycine-aspartate acid (RGD)-conjugated gold nanoparticles were used to follow integrins in high resolution by means of cryo-electron tomography: it is possible to localize AuNPs in cells and identify the precise interactors within cells [115,116]. This development is a clear example of the AuNPs use of structural cell biology.…”

Section: Aunrsmentioning

confidence: 99%

Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review

et al. 2019

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In the last decade, many innovative nanodrugs have been developed, as well as many nanoradiocompounds that show amazing features in nuclear imaging and/or radiometabolic therapy. Their potential uses offer a wide range of possibilities. It can be possible to develop nondimensional systems of existing radiopharmaceuticals or build engineered systems that combine a nanoparticle with the radiopharmaceutical, a tracer, and a target molecule, and still develop selective nanodetection systems. This review focuses on recent advances regarding the use of gold nanoparticles and nanorods in nuclear medicine. The up-to-date advancements will be shown concerning preparations with special attention on the dimensions and functionalizations that are most used to attain an enhanced performance of gold engineered nanomaterials. Many ideas are offered regarding recent in vitro and in vivo studies. Finally, the recent clinical trials and applications are discussed.Radiopharmaceuticals are showing amazing outcomes in diagnostic (90%) and therapeutic (10%) applications for many diseases such as cancer, heart and brain diseases, and so on [33]. They consist of a radioactive nuclide linked to a biologically active molecule directed to the target of interest. When radionuclides emit γ rays (either directly, as pure γ emitters, or indirectly, as β+ emitters), the radiopharmaceutical is intended for diagnostic imaging. When radionuclides emit β− or α particles (thanks to the cell-damaging properties) the radiopharmaceutical is used for therapeutic applications and, in some recent research studies, even for radio-guided surgery [34][35][36]. Theragnostics is a new term that implies the use of the same molecule, labeled with different radionuclides, for both diagnostic and therapeutic purposes [37][38][39].Radiopharmaceuticals have been increasingly used for medical diagnosis since the late 1940s, when nuclear medicine was born. Nuclear medicine aims at evaluating both physiological function as well as biochemical changes in disease conditions; it includes two-dimensional (2D) imaging (planar scintigraphy) and three-dimensional (3D) imaging (single-photon emission computed tomography, SPECT, and positron emission tomography, PET). The functional information obtained by SPECT and PET may need to be coupled with the anatomic/morphologic information typically provided by computed tomography (CT) (hence SPECT and PET are now commonly called SPECT-CT and PET-CT): these approaches, named "hybrid imaging", have many advantages as well as high sensitivity, good spatial resolution, and the possibility to correctly locate functional abnormalities (by the SPECT or PET component) within a definite anatomic field (by the CT component) [34].The γ-emitting radionuclides that are used for planar and SPECT imaging are usually obtained within hospital nuclear medicine facilities (or research departments) from small portable generators; some are produced by nuclear reactors and then shipped to the hospital facility ready to use. The β+ emitting radionuclides ...

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“…We extracted and purified microbial DNA from 200 mL of filtered water (0.22 µm Sterivex filter) while using the PowerWater kit from MO BIO laboratories (Mo Bio, Carlsbad, CA, USA). Microbiomes were then characterized via the targeted gene amplification of the 16S rRNA V4 region, as described elsewhere [28]. Following gel-purification, the libraries were pooled at equimolar ratios and sequenced on the MiSeq Illumina platform adapted for 250-bp paired-end reads (Wright Labs, Juniata College, Huntingdon, PA, USA).…”

Section: Dna Extraction and Sequencingmentioning

confidence: 99%

“…Patterns of diversity within the ASV tables, only including ASVs that appeared at least three times and that were present in at least 10% of the samples, were analyzed using a modified version of the pipeline that was described in Dahan et al [28] and implemented in R version 3.2.3 (R scripts are available upon request). Supplemental File 1 provides a mapping file linking the sample names and the relevant metadata and Supplemental File 2 provides a full description of the statistical and visualization analyses.…”

Section: Processing and Visualization Of 16s Rrna Sequence Datamentioning

confidence: 99%

Triclosan Alters Microbial Communities in Freshwater Microcosms

Clarke

Azulai

Dueker

et al. 2019

Water

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The effect of triclosan on microbial communities that are found in soil and sediments is well documented. However, little is known regarding the possible effects of triclosan on microbial communities that are present in the column of freshwater streams as the antimicrobial is released from sediments or from water sewage outflow. We show that a concentration of triclosan as low as 1 ng/L decreases richness and evenness in freshwater microbial communities growing in the water column while using controlled experimental microcosms. Crucially, the decrease in evenness that was observed in the microbial communities was due to the selection of bacteria commonly associated with human activity, such as Acinetobacter, Pseudomonas, and Rhodobacter, as opposed to an increase in Cyanobacteria, as previously suggested. Finally, our results demonstrate that higher concentrations of triclosan comparable to heavily polluted environments can also impact the overall phylogenetic structure and community composition of microbial communities. Understanding the impact of triclosan on these microbial populations is crucial from a public health perspective as human populations are more often exposed to microbial communities that are present in the water column via recreative use.

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Exposure to Arsenic Alters the Microbiome of Larval Zebrafish

Cited by 52 publications

References 88 publications

Arsenic and the gastrointestinal tract microbiome

Arsenic and the gastrointestinal tract microbiome

Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review

Triclosan Alters Microbial Communities in Freshwater Microcosms

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