Exposure to Chinese Famine in the Early Life, Adulthood Obesity Patterns, and the Incidence of Hypertension: A 22-Year Cohort Study

Wang, Yu; Jin, Jibin; Yue, Peng; Chen, Yongjie

doi:10.1159/000515060

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have also shown that exposed to famine in early life is a risk factor for NAFLD. 20 A larger study by Lu 21 showed that women and men exposed to famine had a significantly higher risk of NAFLD than those not exposed. Data from Chongqing city suggest similar results.…”

Section: Discussionmentioning

confidence: 99%

Association Between NLR and NAFLD in Adults Exposed to Famine in Early Life

Liu¹,

Zhong²,

Li³

et al. 2022

RMHP

View full text Add to dashboard Cite

Exposure to famine in early life has been shown to increase the prevalence of non-alcoholic fatty liver disease (NAFLD). Neutrophil-to-lymphocyte ratio (NLR) is a risk factor for developing NAFLD. However, it is not clear that the association between NLR and NAFLD in individuals who were exposed to famine in early life. Methods: To match for age, we selected two group populations from Xuzhou city, China, on two different occasions, 2013 and 2017. The group recruited in 2013 included participants who were born during a period of great famine in China. Participants in the another group recruited in 2017 were born between 1965 and 1968. Clinical characteristics of individuals as well as serology indexes were examined for all participants. Ultrasonography to diagnose NAFLD was performed by trained doctors. A total of 10,574 participants were included in the final analysis. Results: Individuals born during the famine period have a higher NAFLD prevalence than those who had not been exposed to famine and these findings were similar for both sexes (male: 57.6% vs 48.9%, female: 47.6% vs 40.3%). The prevalence of NAFLD according to NLR quartiles in those exposed to famine was 49.5%, 52.7%, 52.9% and 55.5% for Q1, Q2, Q3 and Q4 NLR, respectively, and was higher than that in nonexposed to famine group. After adjusting for age, BMI, and other metabolic variables, the association between NLR and NAFLD disappeared in the non-famine group. The non-linear relationship between NLR and NAFLD was found in those who had been exposed to famine. Conclusion: Individuals who were exposed to famine in early life have a higher prevalence of NAFLD than those who were not exposed. Compared with lower NLR levels, elevated NLR is a risk factor for developing NAFLD. However, there is a non-linear relationship between NLR and the risk of developing NAFLD.

show abstract

Section: Discussionmentioning

confidence: 99%

Association Between NLR and NAFLD in Adults Exposed to Famine in Early Life

Liu¹,

Zhong²,

Li³

et al. 2022

RMHP

View full text Add to dashboard Cite

show abstract

“…To our knowledge, the effect of famine exposure on CVD risk in MS patients has not been evaluated, but studies confirmed that fetal exposure to famine increases CVD risk in those with the component of MS. A cross-sectional study found that the association between early life famine exposure and adult CVD risk appears to be stronger in overweight than in normal individuals [ 26 ]. Other studies showed that fetal exposure to famine exacerbates the adverse effect of hypertension on CVD, especially in individuals with central obesity [ 6 , 27 ]. Zhang et al found that exposure to famine, especially during fetal life, exacerbates the association between hyperglycemia and CVD.…”

Section: Discussionmentioning

confidence: 99%

Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals

Shu

Ding

Yue

et al. 2022

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background Patients with metabolic syndrome (MS) have a higher incidence of cardiovascular disease (CVD), but the possible mechanisms are not fully understood and further exploration of the possible factors influencing the high incidence of CVD in patients with MS is still needed. Objectives This study aims to examine the association between fetal famine exposure and the risk of CVD in adulthood with MS. Methods Of 13,744 MS patients free of CVD selected from the Kailuan Study in 2006 (referred as the baseline survey) were included in the study. China suffered a severe famine from 1959 to 1962, so the participants born during this period were classified as the uterine famine exposed group. All patients were born between January 1, 1949, and December 31, 1974. Based on the date of birth, all patients were divided into the no-exposed group (born between January 1, 1963, and December 31, 1974), uterine famine exposed group (born between January 1, 1959 and December 31, 1962), and childhood famine exposed group (born between January 1, 1949 and December 31, 1958). After following up to December 31, 2019, the weighted Cox regression analysis model was used to calculate the effect of early life famine exposure in MS individuals on the risk of CVD in adulthood. Results During the 12.12 years of follow-up, the incidence of CVD was 5.87%, 10.13%, and 10.90% in the no-exposed group, uterine famine exposed group, and childhood famine exposed group, respectively. Compared with participants in the no-exposed group, the CVD risk and stroke risk increased in participants in the uterine famine exposed group (for CVD, HR: 1.32, 95% CI 1.04–1.67; for stroke, HR:1.37, 95% CI 1.05–1.79), but not in childhood famine exposed group. However, the increased CVD risks were only observed in females or smokers. No increased MI risks were observed for participants in the uterine famine exposed group or childhood famine exposed group. Conclusions Our findings suggested that exposure to famine during uterine life might increase the risk of CVD in adulthood in participants with MS.

show abstract

“…Among septal e′ is <8 cm/ s, lateral e′ is <10 cm/s, and LAVI ≥34 mL/m 2 , the presence of 2 abnormal measurements was defined as LVDD. The LVDD grade was defined as (1) grade I: the mitral E/A <0.8, deceleration time >200 ms, the average E/e′ ratio is <8 (septal and lateral); (2) grade II: the mitral E/A ratio is 0.8-1.5 and decreases by ≥50% during the Valsalva maneuver, deceleration time is from 160 to 200 ms, the average E/e′ ratio is 9-12; (3) grade III: the E/A ratio ≥2, deceleration time <160 ms, average E/e′ ratio >13. In this study, the proportion of grade II (13.4%) or III (0.3%) diastolic dysfunction was relatively low.…”

Section: Study Outcomes Evaluationmentioning

confidence: 99%

“…However, the underlying mechanisms that connect these factors are not yet fully understood. Previous studies have revealed famine exposure leads to diseases associated with CVD, such as hypertension [2,3], obesity [2,4], nonalcoholic fatty liver disease [5], diabetes [6,7], and metabolic syndrome [8]. The impact of malnutrition during fetal development and low birth weight on cardiac damage in adolescents is well established [9].…”

Section: Introductionmentioning

confidence: 99%

Early Famine Exposure Results in Left Ventricular Remodeled, Diastolic Dysfunction and Systolic Function Preserved in Adults

Zhou,

Feng,

et al. 2023

Ann Nutr Metab

View full text Add to dashboard Cite

Introduction Malnutrition during a critical window of development in a fetus or infant can result in abnormal cardiac remodeling and function. It is uncertain whether the contribution of these effects continues to impact the cardiac remodeling and function of adults over the course of several decades of growth. Our study examined the impact of early Chinese famine exposure on cardiac remodeling, left ventricular (LV) diastolic function, and LV systolic function in adults. Methods Participants at high risk of cardiovascular disease (CVD) from the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project (PEACE MPP) were enrolled. The famine in China lasted from 1959 to 1962. A total of three groups were formed based on the participants' birth dates: pre-famine group, famine exposure group and post famine group. Logistic regression and linear mixed models were used to explore the association between famine exposure and cardiac remodeling, LV diastolic function and LV systolic function in adults. Results The study included 2758 participants, the mean age was 57.05 years and 62.8% were female, 26.4% had LV hypertrophy (LVH), 59.6% had LV diastolic dysfunction (LVDD), 10.5% had reduced global longitudinal strain (GLS). Compared to post-famine exposure, participants had independently increased risk of LVH in the famine exposure group (OR: 2.02, 95%CI: 1.60-2.56) and pre-famine exposure (OR: 1.36, 95%CI: 1.06-1.76). Compared to post-famine exposure, the risk of LVDD remarkably increased in the famine exposure group (OR: 3.04, 95%CI:2.49-3.71), and pre-famine exposure group (OR: 1.87, 95%CI:1.52-2.31). Famine exposure had no significant impact on GLS, but was associated with a significant increase in LV ejection fraction (LVEF) and LV end-diastolic diameter (LVEDD). Significant interactions were observed between the effects of famine exposure and other clinical/sociodemographic variables (gender, systolic blood pressure (SBP) ≥140 mmHg or not, high school or above or not and annual income < 50,000 RMB or not) on these outcomes. Conclusion Exposure to famine, particularly during fetal and infant stages, increases the risk of LVH and LVDD in adults. However, the LV systolic function remains preserved. These impacts are more pronounced in females, individuals with SBP≥140mmHg, those with low income, or those with high educational status.

show abstract

Exposure to Chinese Famine in the Early Life, Adulthood Obesity Patterns, and the Incidence of Hypertension: A 22-Year Cohort Study

Cited by 8 publications

References 26 publications

Association Between NLR and NAFLD in Adults Exposed to Famine in Early Life

Association Between NLR and NAFLD in Adults Exposed to Famine in Early Life

Effects of fetal famine exposure on the cardiovascular disease risk in the metabolic syndrome individuals

Early Famine Exposure Results in Left Ventricular Remodeled, Diastolic Dysfunction and Systolic Function Preserved in Adults

Contact Info

Product

Resources

About