Exposure to chlorpyrifos and cypermethrin alone or in combination induces developmental abnormalities and lung damage in animal models: A review

Shaikh, Nasrul I; Rs, Sethi

doi:10.22271/j.ento.2020.v8.i5aa.7769

Cited by 5 publications

(3 citation statements)

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“…In the study of Abdus Sallam et al 14 a thickening of the alveolar septa contributing to the inflammatory process was detected with the development of bronchopneumonia in CYP‐treated rabbits. It has also been reported that CYP exposure caused of cellular infiltration, necrotic changes, and inflammation of lung tissues in mice 15,16 . The pathological effect of CYP on pigeon lung was demonstrated by hypertrophy and emphysema 17 .…”

Section: Introductionmentioning

confidence: 89%

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Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway

İleritürk

Kandemir

2022

Environmental Toxicology

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Cypermethrin (CYP), a type II synthetic pyrethroid, is the most widely used insecticide worldwide. Inhalation of it may cause side effects. This study is aimed to examine potential protection of quercetin (QUE) which is a well-known antioxidant in CYPinduced lung toxicity. Accordingly, 35 Spraque Dawley male rats were divided into five equal groups as follows: I-Control group, II-QUE group (50 mg/kg/b.w. QUE), III-CYP group (25 mg/kg/b.w. CYP), IV-CYP + QUE 25 (25 mg/kg/b.w. CYP + 25 mg/ kg/b.w. QUE), V-CYP + QUE (25 mg/kg/b.w. CYP + 50 mg/kg/b.w. QUE) were treated with oral gavage throughout 28 days. CYP intoxication was associated with increased malondialdehyde level while glutathione concentration, activities of glutathione peroxidase, superoxide dismutase, and catalase reduced. CYP adminisitration caused of apoptosis in the lung by up-regulating caspase-3 and Bax levels and down-regulating Bcl-2. CYP also caused of endoplasmic reticulum (ER) stress by increasing mRNA transcript levels of PERK, IRE1, ATF6, and GRP78. Additionally, it was observed that CYP administration activated IL-6/JAK2/STAT3/MAPK14 signaling pathway and levels of IL-1β, NF-κB, TNF-α, and iNOS in the lung tissue. Therefore, it was determined that CYP administration triggered autophagy by upregulating LC3A and LC3B mRNA transcript levels. Moreover, the protein levels of NF-κB, caspase-3, Bax, Bcl-2, and cytochorme-c were examined by Western blot analysis. However, cotreatment with QUE at a dose of 25 and 50 mg/kg considerably protective oxidative stress, inflammation, apoptosis, ER stress, autophagy, and IL-6/JAK2/STAT3/MAPK14 signaling pathway in lung tissue. Overall, the findings of this study suggest that lung damage associated with CYP toxicity could be protected by QUE administration.

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Section: Introductionmentioning

confidence: 89%

“…It has also been reported that CYP exposure caused of cellular infiltration, necrotic changes, and inflammation of lung tissues in mice. 15,16 The pathological effect of CYP on pigeon lung was demonstrated by hypertrophy and emphysema. 17 The adverse effects of CYP on the lung have been demonstrated in limited studies but it has not analyzed in a detail way.…”

mentioning

confidence: 99%

Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway

İleritürk

Kandemir

2022

Environmental Toxicology

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“…Extensive studies were conducted with chloropyrifos and cypermethrin in albino rats regarding pulmonary expression of TNF‐α in response to toxicity, on respiratory parameters and sleep apnea by Darwiche et al (2018), on liver and lung toxicity by Yazdinezhad et al (2017), and with respect to reproductive perturbation by Humadi (2011). Some studies highlighted that chloropyrifos and cypermethrin alone or in combination induced developmental abnormalities in exposed vertebrate model (Shaikh & Sethi, 2020). Contrastingly, on the invertebrates there have been noticeably less examples from both laboratory and field investigations.…”

Section: Introductionmentioning

confidence: 99%

Cytopathological and ultrastructural changes in the male reproductive organs of freshwater crab Paratelphusa jacquemontii (Rathbun) exposed to nurocombi

Archunan

Athisuyambulingam

Pradhoshini

et al. 2021

Microscopy Res & Technique

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Accumulation of pollutants in the aquatic system has a high impact on the reproductive physiology of crustaceans. The objective of the present study was to assess the possible histopathological effects of combined chlorpyrifos and cypermethrin (nurocombi) exposure on reproductive tissue in male freshwater crab Paratelphusa jacquemontii using light and electron microscopy. The testis of experimental crabs showed disorganization of testicular lobules, increased inters cellular space, necrosis, and cellular damage in both germinal cells and Sertoli cells. The treated vas deferens exhibited epithelial degeneration, misshaped spermatophores, decline in the number of spermatophores, and dehiscence of spermatophore wall. These clinical manifestations expressed in crabs following the exposure of nurocombi significantly reduce the testicular activity and substantially inhibits the seminal secretions, which ultimately lead to impairment of reproduction.

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Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos

Farhadi,

Daniali,

Baeeri

et al. 2023

Drug and Chemical Toxicology

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Exposure to chlorpyrifos and cypermethrin alone or in combination induces developmental abnormalities and lung damage in animal models: A review

Cited by 5 publications

References 0 publications

Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway

Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway

Cytopathological and ultrastructural changes in the male reproductive organs of freshwater crab Paratelphusa jacquemontii (Rathbun) exposed to nurocombi

Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos

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