Exposure to chronic isolation modulates receptors mRNAs for oxytocin and vasopressin in the hypothalamus and heart

Pournajafi-Nazarloo, Hossein; Kenkel, William M.; Mohsenpour, Seyed Ramezan; Sanzenbacher, Lisa; Saadat, Habibollah; Partoo, Leila; Yee, Jason R.; Azizi, Fereidoun; Carter, C. Sue

doi:10.1016/j.peptides.2013.02.007

Cited by 39 publications

(25 citation statements)

References 59 publications

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“…In female prairie voles two months of social isolation increased plasma AVP responses to social conflict (Grippo et al, 2007a) whereas male and female prairie voles exposed to one hour of isolation per day for four weeks also exhibited increased AVP reactivity (Pournajafi-Nazarloo et al, 2013). The period of single housing we used for resident intruder levels was much shorter (3 days) than periods typically used to study social isolation in rodents.…”

Section: Discussionmentioning

confidence: 99%

“…Stressed females had more OT/c-fos colocalizations in the rostral PVN following resident-intruder testing whereas this effect was not significant in males. Other forms of stress, such as social isolation, have been reported to increase baseline OT release in to blood, primarily in females (Grippo et al, 2007b; Pournajafi-Nazarloo et al, 2013). Interestingly social isolation induced a 3 fold increase in OT/c-fos colocalizations in females and about a 1.5 fold increase in OT/c-fos colocalizations in males following a resident-intruder test (Grippo et al, 2007b).…”

Section: Discussionmentioning

confidence: 99%

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Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Steinman¹,

Laredo²,

López³

et al. 2015

Psychoneuroendocrinology

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Vasopressin signaling has important effects on the regulation of social behaviors and stress responses, and is considered a promising pathway to target for new therapeutics of stress-induced psychiatric disorders. Although there is evidence for sex differences in the behavioral effects of arginine vasopressin (AVP), few data have directly compared the effects of stress on endogenous AVP signaling in males and females. We used California mice (Peromyscus californicus) to study the short and long term effects of social defeat stress on AVP immunoreactive cells in the paraventricular nucleus (PVN) and the posteromedial bed nucleus of the stria terminalis (BNSTmp). Acute exposure to defeat increased AVP/c-fos cells in the PVN and SON of both males and females. In contrast, there were sex differences in the long term effects of defeat. Males but not females exposed to defeat had less avp mRNA in the PVN, and in two experiments defeat reduced the number of AVP positive cells in the caudal PVN of males but not females. Interestingly, during relatively benign social encounters with a target mouse, there was a rapid decrease in AVP percent staining (including cell bodies and fibers) in the PVN of males but not females. Defeat reduced AVP percent staining in males, but did not block the socially induced decrease in percent staining. When mice were tested in resident-intruder tests, males exposed to defeat males were no less aggressive than control males whereas aggression was abolished in females. However, bouts of aggression were positively correlated with the number of AVP neurons in the BNSTmp of control males but not stressed males, suggesting that different mechanisms mediate aggression in control and stressed males. These data show that while acute AVP responses to defeat are similar in males and females, the long term effects of defeat on AVP are stronger in males.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Steinman¹,

Laredo²,

López³

et al. 2015

Psychoneuroendocrinology

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“…Vasopressin 1B receptors are also located in the pituitary and play a role in the control of HPA axis and stress-related behaviors. Results of previous studies had revealed no effect of stress exposure on vasopressin 1A and/or 1B receptor mRNA concentrations in the hypothalamus of rats (Schmidt et al 2003) as well as in prairie voles (Pournajafi-Nazarloo et al 2013). It should be noted that upregulation of vasopressin 1B receptors in response to chronic stress at the pituitary level has been reported (Volpi et al 2004).…”

Section: Discussionmentioning

confidence: 89%

“…Oxytocin receptors are located in several hypothalamic nuclei and their roles in reproductive functions are underlined by changes in binding and/or gene expression during the estrous cycle and pregnancy (Bale et al 1995, Bealer et al 2006. Results from a recent study on prairie voles (Pournajafi-Nazarloo et al 2013), an animal species with specific social behavior, revealed a decrease in oxytocin receptor mRNA concentration in the hypothalamus following chronic isolation. The finding of decreased mRNA concentration of oxytocin receptors in the hypothalamus in atosiban-treated animals appears to be the first evidence on the effect of atosiban on these neuropeptide receptors in the brain.…”

Section: Discussionmentioning

confidence: 99%

Effects of atosiban on stress-related neuroendocrine factors

Babic¹,

Pokusa²,

Danevova³

et al. 2015

Journal of Endocrinology

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Atosiban, an oxytocin/vasopressin receptor antagonist, is used to decrease preterm uterine activity. The risk of preterm delivery is undoubtedly associated with stress, but potential side effects of atosiban on neuroendocrine functions and stress-related pathways are mostly unknown. These studies were designed to test the hypothesis that the chronic treatment of rats with atosiban modulates neuroendocrine functions under stress conditions. Male rats were treated (osmotic minipumps) with atosiban (600 mg/kg per day) or vehicle and were restrained for 120 min/day for 14 days. All animals were treated with a marker of cell proliferation 5-bromo-2-deoxyuridine. Anxiety-like behavior was measured using an elevated plus-maze. Treatment with atosiban failed to modify plasma concentrations of the stress hormones ACTH and corticosterone, but led to a rise in circulating copeptin. Atosiban increased prolactin levels in the non-stressed group. Oxytocin receptor mRNA levels were increased in rats exposed to stress. Treatment with atosiban, in both control and stressed animals, resulted in a decrease in oxytocin receptor gene expression in the hypothalamus. No changes were observed in vasopressin receptor 1A and 1B gene expression. The decrease in hippocampal cell proliferation induced by stress exposure was not modified by atosiban treatment. This study provides the first data, to our knowledge, revealing the effect of atosiban on gene expression of oxytocin receptors in the brain. Atosiban-induced enhancement of plasma copeptin indicates an elevation in vasopressinergic tone with potential influence on water-electrolyte balance.

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“…For exam- 54 ple, prolonged separation from a partner or loss of a partner increases 55 the probability of depression [6,7]. Daily 'handling' or brief separation 56 (15 min) of rat pups from their mothers (BMS) during postpartum 57 weeks 2-3 decreases acute stress-induced anxious behavior and hypo- and depression-like behaviors in mothers [5,11,12]. Interestingly, 63 some studies suggest that repeated brief maternal separation from 64 pups, but not prolonged separation, may also be stressful for Wistar phosphate buffer and 4% paraformaldehyde (pH 7.4), the brain was 208 collected within 3 min.…”

mentioning

confidence: 99%

Postpartum repeated separation from pups affects the behavior and neuroendocrine parameters of mandarin vole fathers

Kong¹,

Wu²,

Wang³

et al. 2015

Physiology & Behavior

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Exposure to chronic isolation modulates receptors mRNAs for oxytocin and vasopressin in the hypothalamus and heart

Cited by 39 publications

References 59 publications

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Effects of atosiban on stress-related neuroendocrine factors

Postpartum repeated separation from pups affects the behavior and neuroendocrine parameters of mandarin vole fathers

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