1999
DOI: 10.1111/j.1574-695x.1999.tb01338.x
|View full text |Cite
|
Sign up to set email alerts
|

Exposure to cigarette smoke, a major risk factor for sudden infant death syndrome: effects of cigarette smoke on inflammatory responses to viral infection and bacterial toxins

Abstract: Exposure to cigarette smoke is a major risk factor for sudden infant death syndrome and also for respiratory infections in children. It has been suggested that toxigenic bacteria colonizing the respiratory tract might play a role in some cases of sudden infant death syndrome and nicotine has been demonstrated to enhance the lethality of bacterial toxins in a model system. Pyrogenic toxins of Staphylococcus aureus have been identified in tissues of infants who died of sudden infant death syndrome. It has been s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
16
0

Year Published

1999
1999
2017
2017

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 33 publications
(17 citation statements)
references
References 39 publications
1
16
0
Order By: Relevance
“…Fever, prone sleeping and blocking of nasal passages with secretions could induce a micro‐environment in which the permissive temperature for induction of potent bacterial toxins is obtained. Virus infections have been demonstrated to enhance the lethality of bacterial toxins in animal models [138] and to enhance induction of inflammatory mediators from human cells in vitro [139,140].…”
Section: Discussionmentioning
confidence: 99%
“…Fever, prone sleeping and blocking of nasal passages with secretions could induce a micro‐environment in which the permissive temperature for induction of potent bacterial toxins is obtained. Virus infections have been demonstrated to enhance the lethality of bacterial toxins in animal models [138] and to enhance induction of inflammatory mediators from human cells in vitro [139,140].…”
Section: Discussionmentioning
confidence: 99%
“…41,42 Exposure of these children to cigarette smoke increased their susceptibility to viral and bacterial infections. 44,45 In smokers, passive coating of mucosal surfaces with components of smoke enhanced bacterial binding to epithelial cells, possibly by altering charge or other properties of the epithelial cell surface. 44,45 In smokers, passive coating of mucosal surfaces with components of smoke enhanced bacterial binding to epithelial cells, possibly by altering charge or other properties of the epithelial cell surface.…”
Section: Effect Of Cigarette Smokingmentioning
confidence: 99%
“…Exposure to cigarette smoke and viral infection are common risk factors for SIDS. The effects of virus infection and exposure to cigarette smoke on induction of inflammatory mediators from human monocytes by staphylococcal toxins were assessed as both nicotine and virus infections have been shown to enhance the lethality of bacterial toxins [35]. The effects of cortisol levels on inflammatory responses of infants is explored in the paper by Gordon et al with reference to the peak incidence at 2–4 months and the night‐time prevalence of these deaths [36].…”
Section: Evidence For Inflammatory Responses In Sidsmentioning
confidence: 99%