Exposure to di(2-ethylhexyl) phthalate in premature neonates in a neonatal intensive care unit in Taiwan

Su, Pen‐Hua; Chang, Yan‐Zin; Chang, Hua-Pin; Wang, Shu Li; Haung, Hsin-I; Huang, Po-Chin; Chen, Jia-Yuh

doi:10.1097/pcc.0b013e3182455558

Cited by 41 publications

(23 citation statements)

References 34 publications

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“…It has previously been shown that premature children are highly exposed to DEHP from medical equipment (Silva et al 2006; Su et al 2012; Weuve et al 2006). It was assumed that this exposure was restricted to DEHP (Weuve et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Current risk assessments do not account for this. Because the carboxylated metabolite of DEHP has only recently become available, previous studies on DEHP exposure of newborns may have systematically underestimated exposure levels (Su et al 2012; Weuve et al 2006). …”

Section: Discussionmentioning

confidence: 99%

“…Despite these concerns, data on phthalate exposure levels during this period of life are sparse (Adibi et al 2008; Enke et al 2013; Sathyanarayana et al 2008a, 2008b). Some studies have reported extremely high exposure to di(2-ethylhexyl) phthalate (DEHP) during hospitalization in preterm children (Silva et al 2006; Su et al 2012; Weuve et al 2006), suggesting a risk of adverse health effects in this group as gonadal development is not completed (Rey and Josso 2013) and detoxification processes are still immature (Coughtrie et al 1988; Tan et al 1990). …”

Section: Introductionmentioning

confidence: 99%

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A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Frederiksen

Kuiri-Hänninen

Main

et al. 2014

Environ Health Perspect

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Background: Some phthalates have shown antiandrogenic effects in rat offspring. Premature infants may be exposed to high amounts of specific phthalates during hospitalization, and thus are potentially at risk.Objective: We evaluated longitudinal phthalate exposure and metabolism in full-term (FT) and preterm (PT) infants.Methods: Fifty-eight FT and 67 PT (gestational age, 24.7–36.6 weeks) infants were recruited at birth and followed until 14 months (nine times). Urinary concentrations of metabolites of diethyl phthalate (DEP), dibutyl phthalate isomers (DiBP and DnBP), butylbenzyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), and diisononyl phthalate (DiNP) were measured in 894 samples. Daily intake and a hazard index for antiandrogenic effects were estimated, and excretion patterns of DEHP and DiNP metabolites were analyzed.Results: Metabolites of BBzP, DiNP, and DEHP were 5–50 times higher at day 7 (D7) and month 1 (M1) in PT than in FT infants. Thereafter, metabolite concentrations were similar between the two groups. The estimated hazard index for combined DiBP, DnBP, BBzP, and DEHP exposures 7 days after birth exceeded the antiandrogenic threshold in > 80% of PT and > 30% of FT infants, and after M2, in 30% of all infants. The excretion pattern of DEHP and DiNP metabolites changed with age.Conclusion: Most PT infants and approximately one-third of healthy FT newborns were exposed to phthalates during early life at a potentially harmful level according to the European Food Safety Authority’s recommended limits of daily exposure. Changes in the relative proportions of secondary phthalate metabolites over time were consistent with maturation of infant metabolic pathways during the first year of life. Further research is needed on the health effects of phthalate exposures and the influence of changes in metabolic capacity in neonates and infants.Citation: Frederiksen H, Kuiri-Hänninen T, Main KM, Dunkel L, Sankilampi U. 2014. A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months. Environ Health Perspect 122:998–1005; http://dx.doi.org/10.1289/ehp.1307569

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Frederiksen

Kuiri-Hänninen

Main

et al. 2014

Environ Health Perspect

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“…Typical daily phthalate intake in humans is estimated at 1.7-52.1 μg/kg/day (Doull et al, 1999;Koch et al, 2003;McKee et al, 2004;Frederiksen et al, 2011;Martinez-Arguelles et al, 2013), whereas children exposure is 2-to 4-fold higher than adults (Koch et al, 2005;Moody et al, 2013). Moreover, individuals, especially children with long-term medical conditions have much greater exposure than general population since the use of phthalates in medications and medical devices (Moody et al, 2013), with an estimated exposure of 20 mg phthalate per day (Plonait et al, 1993;Green et al, 2005;Su et al, 2012;Moody et al, 2013). Phthalates are considered to be one of the major groups of antiandrogenic substances (Grady and Sathyanarayana, 2012;Knez, 2013).…”

Section: Phthalatesmentioning

confidence: 97%

Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system

Falco

Forte

Laforgia

2015

Front. Environ. Sci.

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Endocrine disrupting chemicals (EDCs) are identified for their ability to perturb the homeostasis of endocrine system and hormonal balance. The male reproductive system is under close control of hormones and each change in their concentration and time of exposition and action can induce a deregulation of its physiology. In this review we summarize the most recent studies on two main categories of EDCs with different action: the estrogenic bisphenol A and alkylphenols and the anti-androgenic phthalates. This review describes the main effects of these substances on male reproductive system

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“…17 Infants maintained on parenteral nutrition exhibit variable increases in serum concentrations of DEHP at the end of the treatment period. 18 Given these findings, use of polyvinyl chloride-free medical devices is recommended in neonatal intensive care units.…”

Section: Phthalatesmentioning

confidence: 99%

The effects of environmental chemicals on renal function

2015

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The global incidence of chronic kidney disease (CKD) is increasing among individuals of all ages. Despite advances in proteomics, genomics and metabolomics, there remains a lack of safe and effective drugs to reverse or stabilize renal function in patients with glomerular or tubulointerstitial causes of CKD. Consequently, modifiable risk factors that are associated with a progressive decline in kidney function need to be identified. Numerous reports have documented the adverse effects that occur in response to graded exposure to a wide range of environmental chemicals. This Review summarizes the effects of such chemicals on four aspects of cardiorenal function: albuminuria, glomerular filtration rate, blood pressure and serum uric acid concentration. We focus on compounds that individuals are likely to be exposed to as a consequence of normal consumer activities or medical treatment, namely phthalates, bisphenol A, polyfluorinated alkyl acids, dioxins and furans, polycyclic aromatic hydrocarbons and polychlorinated biphenyls. Environmental exposure to these chemicals during everyday life could have adverse consequences on renal function and might contribute to progressive cumulative renal injury over a lifetime. Regulatory efforts should be made to limit individual exposure to environmental chemicals in an attempt to reduce the incidence of cardiorenal disease.

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Exposure to di(2-ethylhexyl) phthalate in premature neonates in a neonatal intensive care unit in Taiwan

Cited by 41 publications

References 34 publications

A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system

The effects of environmental chemicals on renal function

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