Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

Abstract

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Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort

“…Recently, increased levels of primary bile acids have been linked to risk of HCC in humans [60]. Animal and human studies also suggests that PFAS impact bile acid metabolism, increasing risk of liver injury [34,61]. The third compound associated with both PFOS and HCC was Butyric acid, a short chain fatty acid which is primarily produced via intestinal fermentation.…”

“…In adults, PFAS have also been linked to alterations in cytokeratin 18, a marker for liver apoptosis [32,33]. Recent evidence also suggests that PFAS are associated with increased risk of NAFLD, diagnosed using liver MRI or liver biopsy, in both children and adults [34,35]. Using untargeted metabolomics, these studies have also shown that alterations in lipid and amino acid metabolism link PFAS exposure and risk of NAFLD [34,35].…”

“…Recent evidence also suggests that PFAS are associated with increased risk of NAFLD, diagnosed using liver MRI or liver biopsy, in both children and adults [34,35]. Using untargeted metabolomics, these studies have also shown that alterations in lipid and amino acid metabolism link PFAS exposure and risk of NAFLD [34,35]. However, research examining PFAS exposure and hepatocellular carcinoma in humans is non-existent.…”

CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets

“…7 ). Therefore, we have utilized ChemRICH analysis ( Barupal and Fiehn, 2017 ) to identify the PFOA associated chemical sets, which suggested that PFOA exposure has a negative effect on most of the lipid sets except triglycerides ( Sen et al, 2022 ; Sinisalu et al, 2020 ). PFOA exposure may have also induced the amino acid and tocopherol metabolism pathways.…”

IDSL.CCDB: a database for exploring inter-chemical correlations in metabolomics and exposomics datasets

“…Identifying these chemical sets can assist in understanding the systematic metabolic effect of PFOA exposure which can span over multiple metabolic pathways (Figure 8). Therefore, we have utilized ChemRICH analysis 77 to identify the PFOA associated chemical sets, which suggested that PFOA exposure has a negative effect on most of the lipid sets except triglycerides 79, 80 . PFOA exposure may have also induced the amino acid and tocopherol metabolism pathways.…”