Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

Liang, Yipu; Pan, Zijian; Zhu, Meiling; Gao, Ruonan; Wang, Yijue; Yi-juan, Cheng; Zhang, Nannan

doi:10.3389/fnut.2023.1121826

Cited by 14 publications

(5 citation statements)

References 128 publications

(179 reference statements)

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“…Importantly, it is necessary to consider complex interactions between essential trace elements (such as Se, zinc, copper, iron and manganese) and non-essential metals (such as lead, cadmium, arsenic, and mercury) in organisms [112]. Similar to the well-documented protective role of Se and Zn, exposure to Cd, Pb, As and Hg has been connected to various heart diseases [113,114].…”

Section: Discussionmentioning

confidence: 99%

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

et al. 2023

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Selenium is an essential trace element that is essential for various metabolic processes, protection from oxidative stress and proper functioning of the cardiovascular system. Se deficiency has long been associated with multiple cardiovascular diseases, including endemic Keshan’s disease, common heart failure, coronary heart disease, myocardial infarction and atherosclerosis. Through selenoenzymes and selenoproteins, Se is involved in numerous crucial processes, such as redox homeostasis regulation, oxidative stress, calcium flux and thyroid hormone metabolism; an unbalanced Se supply may disrupt these processes. In this review, we focus on the importance of Se in cardiovascular health and provide updated information on the role of Se in specific processes involved in the development and pathogenesis of atherosclerosis (oxidative stress, inflammation, endothelial dysfunction, vascular calcification and vascular cell apoptosis). We also discuss recent randomised trials investigating Se supplementation as a potential therapeutic and preventive agent for atherosclerosis treatment.

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Section: Discussionmentioning

confidence: 99%

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

et al. 2023

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“…Arsenic is a non-essential element for human health because it is without a known nutritional or metabolic role and is not a constituent of any enzyme [ 306 , 307 ]. Similar to other non-essential metals like cadmium, arsenic, lead, nickel, barium, chromium, and mercury, it is harmful to health even at low concentrations [ 25 , 26 , 306 ]. Arsenic is commonly consumed together with food and affects intestinal homeostasis by disrupting barrier function and inducing inflammatory responses [ 308 ].…”

Section: Arsenicmentioning

confidence: 99%

“…Other forms include organic arsenic and arsine (AsH 3 ) [ 311 ]. Reviewing the abundant reports, arsenic shows variable degrees of toxicity with As 2 O 3 as one of the most powerful poisons [ 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , 331 , 332 ]. The liver is the primary target organ not only for toxicity but also for the metabolism of arsenicals with its major metabolic pathway being via methylation [ 311 , 332 ], which leads to the methylated intermediates of monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) [ 332 ].…”

Section: Arsenicmentioning

confidence: 99%

Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury

Teschke

2024

IJMS

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Humans are continuously exposed to various heavy metals including copper, iron, cadmium, and arsenic, which were specifically selected for the current analysis because they are among the most frequently encountered environmental mankind and industrial pollutants potentially causing human health hazards and liver injury. So far, these issues were poorly assessed and remained a matter of debate, also due to inconsistent results. The aim of the actual report is to thoroughly analyze the positive as well as negative effects of these four heavy metals on human health. Copper and iron are correctly viewed as pollutant elements essential for maintaining human health because they are part of important enzymes and metabolic pathways. Healthy individuals are prepared through various genetically based mechanisms to maintain cellular copper and iron homeostasis, thereby circumventing or reducing hazardous liver and organ injury due to excessive amounts of these metals continuously entering the human body. In a few humans with gene aberration, however, liver and organ injury may develop because excessively accumulated copper can lead to Wilson disease and substantial iron deposition to hemochromatosis. At the molecular level, toxicities of some heavy metals are traced back to the Haber Weiss and Fenton reactions involving reactive oxygen species formed in the course of oxidative stress. On the other hand, cellular homeostasis for cadmium and arsenic cannot be provided, causing their life-long excessive deposition in the liver and other organs. Consequently, cadmium and arsenic represent health hazards leading to higher disability-adjusted life years and increased mortality rates due to cancer and non-cancer diseases. For unknown reasons, however, liver injury in humans exposed to cadmium and arsenic is rarely observed. In sum, copper and iron are good for the human health of most individuals except for those with Wilson disease or hemochromatosis at risk of liver injury through radical formation, while cadmium and arsenic lack any beneficial effects but rather are potentially hazardous to human health with a focus on increased disability potential and risk for cancer. Primary efforts should focus on reducing the industrial emission of hazardous heavy metals.

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“…Arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), and lead (Pb) have no nutritional value at low concentrations and may be harmful. Furthermore, both essential and probably essential elements can cause toxic effects at high concentrations [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Risk Assessment of As, Cd, Cr, and Pb via the Consumption of Seafood in Haikou

Lin,

Luo,

et al. 2024

Preprint

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In order to mitigate the risk of excessive heavy metal intake, a study was conducted to assess the levels of arsenic (As), cadmium (Cd), chromium (Cr), and lead (Pb) contamination in 23 edible seafood species obtained from markets in Haikou. The findings were analyzed to evaluate the potential health hazards posed to the local population through consumption. The metals were detected via inductively coupled plasma mass spectrometry (ICP-MS) for quantification. The non-carcinogenic and carcinogenic health risks in humans were assessed via target hazard quotient (THQ), combined target hazard quotient (CTHQ), and target cancer risk (TR). The results indicated that the rank order based on the median metal concentration was As > Cd > Cr > Pb. THQ and CTHQ showed that nine seafood species posed a non-carcinogenic risk regarding from As and Cd consumption separately, or the four targeted metals ingestion together. TR assessment indicated that the inorganic arsenic (InAs) in all the species presented a carcinogenic risk to coastal residents. The Cd content in bivalves, algae, and several crustacean(Mantis Shrimp, Orchid Crab, Redspot Swimming Crab) and fish species(Japanese Scad, Pacific Saury), and Cr levels in most bivalve species(Razor Clams,White Clams, Fan Shells, Oysters, Blood Clams) presented a carcinogenic risk. The As, Cd, Pb, and Cr levels of seafood in Haikou were assessed species presented a potential health risk. Necessitating stricter risk should be management and detection capability and monitoring will be improved.

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Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

Cited by 14 publications

References 128 publications

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury

Risk Assessment of As, Cd, Cr, and Pb via the Consumption of Seafood in Haikou

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