Exposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis

Seomun, Gyeong Ae; Lee, Jun-Young; Park, Jin Kyung

doi:10.1371/journal.pone.0251628

Cited by 32 publications

(15 citation statements)

References 50 publications

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“…Exposure to ELF-MF during childhood was found to have “some” evidence as a risk factor of childhood leukemia. All meta-analyses had summary RR of >1.00 [ 77 , 78 , 79 , 80 , 81 , 82 ], including a recent publication by Seomun et al [ 82 ]. On the contrary, Amoon et al [ 81 ] reported no association in another recent publication.…”

Section: Resultsmentioning

confidence: 99%

“…Their evaluation was based on a pooled analysis (individual level data) of four studies published between 2015 and 2017 [ 83 , 84 , 85 , 86 ]. These four studies were also in the systematic review of Seomun et al [ 82 ]. Paternal smoking during childhood was found to have “little” evidence as a risk factor of childhood ALL but not maternal smoking in the same exposure window [ 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…Inconsistent epidemiologic studies have prompted a debate on the carcinogenicity of some risk factors of childhood leukemia [ 74 , 75 , 82 ]. This is mainly due to the challenges in measuring exposures accurately (information bias), participation and recall biases [ 17 , 111 ].…”

Section: Discussionmentioning

confidence: 99%

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Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review

Onyije

Olsson

Baaken

et al. 2022

Cancers

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Leukemia is the most common type of cancer among children and adolescents worldwide. The aim of this umbrella review was (1) to provide a synthesis of the environmental risk factors for the onset of childhood acute lymphoblastic leukemia (ALL) by exposure window, (2) evaluate their strength of evidence and magnitude of risk, and as an example (3) estimate the prevalence in the German population, which determines the relevance at the population level. Relevant systematic reviews and pooled analyses were identified and retrieved through PubMed, Web of Science databases and lists of references. Only two risk factors (low doses of ionizing radiation in early childhood and general pesticide exposure during maternal preconception/pregnancy) were convincingly associated with childhood ALL. Other risk factors including extremely low frequency electromagnetic field (ELF-MF), living in proximity to nuclear facilities, petroleum, benzene, solvent, and domestic paint exposure during early childhood, all showed some level of evidence of association. Maternal consumption of coffee (high consumption/>2 cups/day) and cola (high consumption) during pregnancy, paternal smoking during the pregnancy of the index child, maternal intake of fertility treatment, high birth weight (≥4000 g) and caesarean delivery were also found to have some level of evidence of association. Maternal folic acid and vitamins intake, breastfeeding (≥6 months) and day-care attendance, were inversely associated with childhood ALL with some evidence. The results of this umbrella review should be interpreted with caution; as the evidence stems almost exclusively from case-control studies, where selection and recall bias are potential concerns, and whether the empirically observed association reflect causal relationships remains an open question. Hence, improved exposure assessment methods including accurate and reliable measurement, probing questions and better interview techniques are required to establish causative risk factors of childhood leukemia, which is needed for the ultimate goal of primary prevention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review

Onyije

Olsson

Baaken

et al. 2022

Cancers

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“…Epidemiological studies have primarily been performed for identifying long-term health impacts, including the causes of pediatric cancer, which have attracted public attention because of the vulnerability of children during their growth period [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Identifying the knowledge structure of electromagnetic fields and health research: Text network analysis and topic modeling

2022

Self Cite

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Background With technological and scientific advancement, people are being increasingly exposed to electromagnetic fields, particularly from portable devices such as mobile phones. However, there is currently no consensus regarding the health effects of electromagnetic field exposure, despite the large amount of research conducted on this topic. This study aimed to understand the knowledge structure and trend of electromagnetic field and health research through text network analysis and topic modeling. Methods PubMed, Embase, and Cochrane were searched, and 3,880 articles published before June 2021 were identified. We explored the main keywords and research topics regarding electromagnetic fields and human health by constructing a network of keywords. A social network analysis program was used to analyze the data, visualize the network, and perform topic modeling. Results Four keywords, “exposure,” “effect,” “cell,” and “cancer,” were highly correlated to other keywords and formed each colony in the knowledge structure of research on electromagnetic fields and health. Five topics were derived from topic modeling: cell research, research on the adaption of MRI, health effects of mobile phones, pain therapy, and exposure measurement. Cell research has been continuously performed, and many studies have been conducted on the health effects of mobile phones since 2000. Conclusions These findings will assist in gaining insights into and understanding changes in research on the health effects of electromagnetic fields, and suggest important areas and directions for future research.

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“…In 2002, The International Agency for Research on Cancer (IARC) revealed that extremely low frequency (ELF) magnetic fields are 'possibly carcinogenic to humans' [12][13][14][15]. Most of the neural activities in the brain are processed through electrical impulses.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic investigation of tau protein conformational changes by static magnetic field exposure

Darwish

2022

J. Phys. Commun.

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Electromagnetic fields taint the molecular environment of proteins and induce changes in the central nervous system. This research applied Fourier transform infrared spectroscopic analysis to investigate the effects of static magnetic fields on tau protein in neurological disorders. It explores the conformational changes of tau protein and highlights its’ potential application as a pathological biomarker for early detection and therapeutic interventions. The results indicate that tau protein is susceptible to magnetic field exposure in the amide B, fingerprint, and amide regions (IV-VI). Changes in peak positions and band intensities were identified and delineated as the outcome effect of magnetic forces on molecular vibrations. Magnetic forces may affect the microtubule structure of the tau protein, leading to protein aggregation. These results indicate the potential application of FTIR spectroscopy for the early detection and classification of degenerative diseases through spectrum analysis. Different magnetic fields can be used as spontaneous therapeutic procedures to induce changes in the molecular environment of proteins.

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Exposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis

Cited by 32 publications

References 50 publications

Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review

Environmental Risk Factors for Childhood Acute Lymphoblastic Leukemia: An Umbrella Review

Identifying the knowledge structure of electromagnetic fields and health research: Text network analysis and topic modeling

Spectroscopic investigation of tau protein conformational changes by static magnetic field exposure

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