Exposure to heavy metals (lead, cadmium and mercury) and its effect on the outcome of in-vitro fertilization treatment

Al‐Saleh, Iman; Coşkun, Serdar; Mashhour, Abdullah; Shinwari, Neptune; El‐Doush, Inaam; Billedo, Grisellhi; Jaroudi, Kamal; Alshahrani, Abdulaziz; Al-Kabra, Maya; Mohamed, Gamal

doi:10.1016/j.ijheh.2007.09.005

Cited by 102 publications

(45 citation statements)

References 58 publications

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“…Neither was any association suggested for Cd and Pb concentrations and biochemical pregnancy during multivariable regression in the study by Al-Saleh et al [30].…”

Section: Discussionmentioning

confidence: 73%

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Wdowiak¹,

Wdowiak²,

Bojar³

2018

Ann Agric Environ Med.

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This study investigated the influence of cadmium (Cd), copper (Cu), iron (Fe), lead (Pb), selenium (Se), and zinc (Zn) in follicular fluid on the effectiveness of in vitro fertilization (IVF) treatment and the dynamics of embryo development. The study involved 221 women aged 25-35 years in whom intracytoplasmic sperm injection (ICSI) was performed. Analysis of the effects of the average concentrations of Se, Zn, and Cu on the developmental dynamics of embryos showed that higher concentrations of these metals were accompanied by shorter lead times for each of the various stages of development, while the reverse was true in the case of cadmium and lead. No relationship was observed between the mean concentrations of Fe and the dynamics of the human embryo. In order to discover whether the fact of becoming pregnant is affected by the investigated variables, a logistic regression model was applied. The dependent variable was the fact of achieving pregnancy, and the independent variable tested was the level of trace metals. Ultimately, only one variable remained statistically significant in the model: the level of Se.

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“…Neither was any association suggested for Cd and Pb concentrations and biochemical pregnancy during multivariable regression in the study by Al-Saleh et al [30].…”

Section: Discussionmentioning

confidence: 73%

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Wdowiak¹,

Wdowiak²,

Bojar³

2018

Ann Agric Environ Med.

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“…Cadmium may affect fertility and fecundity via alterations in reproductive hormones, discussed above, or through oxidative stress and inflammatory pathways. Our review identified five studies that met our inclusion criteria with regard to cadmium and fertility outcomes [47••, 48, 49••, 50, 51]. Two evaluated time to pregnancy among healthy couples, and three evaluated fertilization and ongoing pregnancy rates among couples undergoing in vitro fertilization (IVF).…”

Section: Reproductive Healthmentioning

confidence: 99%

“…Two evaluated time to pregnancy among healthy couples, and three evaluated fertilization and ongoing pregnancy rates among couples undergoing in vitro fertilization (IVF). Of note is that cadmium levels were measured in urine, blood [48, 49••], and follicular fluid [47••, 50, 51] when evaluating effects on fertility. Follicular fluid is a particularly biologically relevant measure of exposure for reproductive endpoints due to its proximity to endometrial tissues, as well as its direct contact with follicular cells responsible for synthesizing and secreting ovarian hormones which communicate in both a paracrine and endocrine manner with the entire HPG axis.…”

Section: Reproductive Healthmentioning

confidence: 99%

Cadmium and Reproductive Health in Women: A Systematic Review of the Epidemiologic Evidence

Pollack

Ranasinghe

Sjaarda

et al. 2014

Curr Envir Health Rpt

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An evolving body of evidence supports that cadmium, a non-essential heavy metal, may be associated with multiple adverse women’s reproductive health outcomes. Our objective was to conduct a systematic review of epidemiologic studies that evaluated cadmium exposure and the following reproductive health outcomes: puberty/menarche, fertility, time to pregnancy, pregnancy loss, preeclampsia, endometriosis, uterine leiomyoma, and menopause. Twenty-two studies were identified based upon our search criteria. Available evidence was inadequate to draw meaningful conclusions for most of the reproductive outcomes studied. The strongest evidence was for a possible association between cadmium and preeclampsia, which was limited to cross-sectional studies. Some evidence, although conflicting, was also observed for fertility related outcomes. This lack of evidence underscores the need for additional research on cadmium and women’s reproductive health outcomes.

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“…They can cause multifarious diseases, depending on the exposure levels and the chemical form of the toxic heavy metal. 4 A well-known example of heavy-metal poisoning is the Itai-itai disease (itai = pain in Japanese), which was caused by cadmium pollution in the Jinzhu River Basin in Japan. However, the accumulation of toxic heavy metals in rivers and lakes is increasing significantly because of human activities such as mining and industrialization of countries around the globe, especially in developing countries such as India and China.…”

mentioning

confidence: 99%

Complexation of Cyclohexanocucurbit[6]uril with Cadmium Ions: X-ray Crystallographic and Electrochemical Study

Feng

Xue

et al. 2010

Inorg. Chem.

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Complexation of cyclohexanocucurbit[6]uril (Q*[6]), a water-soluble cucurbit[n]uril derivative, with Cd(2+) ions has been studied by means of cyclic voltammetry and differential pulse voltammetry. The electrochemical experimental data prove the formation of a highly stable 1:6 Q*[6]/Cd(2+) complex. We also obtained the single-crystal X-ray structure of a cadmium ion complex with Q*[6], in which each portal of Q*[6] chelates three cadmium ions. The present study suggests the potential utility of Q*[6] as an effective cadmium ion chelator and extractant.

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Exposure to heavy metals (lead, cadmium and mercury) and its effect on the outcome of in-vitro fertilization treatment

Cited by 102 publications

References 58 publications

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Evaluation of trace metals in follicular fluid in ICSI-treated patients

Cadmium and Reproductive Health in Women: A Systematic Review of the Epidemiologic Evidence

Complexation of Cyclohexanocucurbit[6]uril with Cadmium Ions: X-ray Crystallographic and Electrochemical Study

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