Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha

Contardo-Jara, Valeska; Lorenz, Claudia; Pflugmacher, Stephan; Nützmann, Gunnar; Kloas, Werner; Wiegand, Claudia

doi:10.1016/j.aquatox.2011.07.017

Cited by 143 publications

(55 citation statements)

References 41 publications

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“…The assessment of CBZ ecotoxicological impact revealed that the oxidative stress induced by CBZ in aquatic organisms is related to its accumulation (Quinn et al, 2008;Vernouillet et al, 2010;Contardo-Jara et al, 2011;Tsiaka et al, 2013). In the present study, LPO levels at the control condition were similar (11 ± 2 nmol MDA/g FW) to those found in clams collected from the environment.…”

Section: Discussionsupporting

confidence: 73%

“…The ability of organisms to accumulate CBZ (under laboratory or field conditions) has been reported in recent studies (Ramirez et al, 2007;Vernouillet et al, 2010;Contardo-Jara et al, 2011;Garcia et al, 2012;Martínez-Bueno et al, 2013). CBZ is relatively hydrophobic, enabling the capacity to partition into the lipid portion of the organisms and bioaccumulate (Liu et al, 2015).…”

Section: Discussionmentioning

confidence: 98%

“…philippinarum (Adams & Reeve, 1850), commonly known as the Manila clam, was selected to study the ecotoxicological impact of CBZ in the Ria de Aveiro. This species has already been used in previous studies, under laboratory and field conditions, to assess the toxicity of CBZ (Aguirre-Martínez et al, 2013a, 2013bAlmeida et al, 2014) as well as other pharmaceutical drugs (Contardo-Jara et al, 2011;Matozzo et al, 2012a;Antunes et al, 2013;Milan et al, 2013) and to assess organic and metal pollution (Riba et al, 2004;Martín-Díaz et al, 2007;Figueira et al, 2012). All these studies demonstrated the suitability of R. philippinarum as a bioindicator species in marine environment quality assessment.…”

Section: Study Area and Test Organismmentioning

confidence: 93%

“…Oetken et al, 2005;Zhang et al, 2012). Moreover, chronic studies performed with environmental concentrations have shown that CBZ can affect multiple oxidative and biochemical pathways in bivalves, with significant deleterious effects (Martin-Diaz et al, 2009;Contardo-Jara et al, 2011;Chen et al, 2014). The impact of CBZ was reported in other species, namely algae (Tsiaka et al, 2013), crustacean (Aguirre-Martínez et al, 2013a) and fish (Gagné et al, 2006a;Li et al, 2009Li et al, , 2010.…”

Section: Introductionmentioning

confidence: 99%

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Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Almeida

Freitas

Calisto

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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The impacts of carbamazepine (CBZ) on aquatic organisms are yet not well investigated. The present study aimed to better understand the chronic effects of environmentally relevant concentrations of CBZ. The experiment was performed by exposing the filter feeding clam Ruditapes philippinarum to 0.00, 0.03, 0.30, 3.00 and 9.00 μg/L, during 28 days. To assess the chronic toxicity of the drug a battery of biomarkers related with health status and oxidative stress was applied. In order to quantify CBZ in the clam's tissues and in water samples ELISA was used. The present study showed three types of responses on the clams after a chronic exposure to CBZ. For control condition and the lower concentrations (0.03 and 0.30 μg/L) a "similar" metabolic state was observed and the most efficient antioxidant status leading to the elimination of reactive oxygen species formed during the metabolism of CBZ. The concentration of 3.00 μg/L seemed to be a "threshold" concentration, beyond which the concentration levels of CBZ began to exert a toxic effect, compromising the activity of biotransformation and antioxidant enzymes, with notorious effects at the highest CBZ concentration (9.00 μg/L). CBZ also seemed to alter the energy-related responses, especially the glycogen and electron system responses, revealing a slowdown in metabolism at the higher exposure concentrations (3.00 and 9.00 μg/L). Overall, the present study demonstrated that the higher CBZ concentrations can lead to the impairment of antioxidant enzymes compromising the neutralization of reactive oxygen species, and thus the ability to cope with oxidative stress.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Section: Study Area and Test Organismmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Almeida

Freitas

Calisto

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…observed in the digestive glands of mussels exposed to certain pharmaceuticals (Contardo-Jara et al 2011). Clear relationships between MXR induction and contamination by Cd, mercury, Zn, Cu have been also reported (Minier et al 2000;Eufemia and Epel 2000;Achard et al 2004;Franco et al 2006).…”

mentioning

confidence: 85%

Evaluation of Multixenobiotic Resistance in Dreissenid Mussels as a Screening Tool for Toxicity in Freshwater Sediments

Ács

Imre²,

Kiss³

et al. 2015

Arch Environ Contam Toxicol

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Occurrence, Human Health Risks, and Removal of Pharmaceuticals in Aqueous Systems: Current Knowledge and Future Perspectives

Gwenzi

Kanda

Danha

et al. 2021

Applied Water Science Volume 1

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Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha

Cited by 143 publications

References 41 publications

Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Chronic toxicity of the antiepileptic carbamazepine on the clam Ruditapes philippinarum

Evaluation of Multixenobiotic Resistance in Dreissenid Mussels as a Screening Tool for Toxicity in Freshwater Sediments

Occurrence, Human Health Risks, and Removal of Pharmaceuticals in Aqueous Systems: Current Knowledge and Future Perspectives

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