Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators

Fernandes, Eliana Jardim; Poetini, Márcia Rósula; Barrientos, Magna Sotelo; Bortolotto, Vandreza Cardoso; Araújo, Stífani Machado; Musachio, Elize Aparecida Santos; Carvalho, Amarilis Santos de; Leimann, Fernanda Vitória; Gonçalves, Odinei Hess; Ramborger, Bruna Piaia; Roehrs, Rafael; Prigol, Marina; Guerra, Gustavo Petri

doi:10.1016/j.cbi.2021.109431

Cited by 32 publications

(22 citation statements)

References 63 publications

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“…Parkinson’s disease is a neurodegenerative disease, characterized by the loss of dopaminergic neurons, cholinergicalterations, and oxidative damage. Lutein-loaded nanoparticles protected against locomotor damage and neurotoxicity induced by a Parkinson’s disease model in Drosophila melanogaster , so lutein-loaded nanoparticles may be an alternative treatment for rotenone-induced damage . Ischemia-reperfusion (I/R) induced rats with vasculitic neuropathic pain and neuropathy were given lutein orally or intragastric.…”

Section: Bioactivity Of Luteinmentioning

confidence: 66%

“…Luteinloaded nanoparticles protected against locomotor damage and neurotoxicity induced by a Parkinson's disease model in Drosophila melanogaster, so lutein-loaded nanoparticles may be an alternative treatment for rotenone-induced damage. 69 Ischemia-reperfusion (I/R) induced rats with vasculitic neuropathic pain and neuropathy were given lutein orally or intragastric. The results prove that lutein is potentially useful in the treatment of I/R-related neuropathy and neuropathic pain.…”

Section: Bioactivity Of Luteinmentioning

confidence: 99%

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Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Zhao

Ci²,

Pang

et al. 2022

ACS Agric. Sci. Technol.

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Lutein, [(3R,3′R,6′R)-β,ε-carotene-3,3′-diol], is a C40 hydroxyl carotenoid. Its chemical structure is based on an unsaturated polyene chain skeleton, and there are one ε-ring and one β-ring on both sides of the skeleton, with a hydroxyl group on the 3′ site of each ring. Lutein is one of the important lipophilic isoprenes from mainly plants and algae. The wide range of sources makes the study of lutein quite comprehensive. The biosynthetic pathway and biochemical activities of lutein have been extensively studied and revealed. Lutein has been extensively studied for its important bioactivity, including for use in functional foods and medicines for brain health, eye-related diseases, skin health, and cancers. This review of lutein summarizes the major studies on bioactivity, metabolism, stability, digestive absorption, lutein delivery systems, and biotechnology.

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Section: Bioactivity Of Luteinmentioning

confidence: 66%

Section: Bioactivity Of Luteinmentioning

confidence: 99%

Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Zhao

Ci²,

Pang

et al. 2022

ACS Agric. Sci. Technol.

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show abstract

“…In a cerebral palsy rabbit model, intravenous treatment of dendrimer-based N-acetyl- l -cysteine (NAC) [ 299 ], a glutathione precursor with antioxidant and anti-inflammatory properties [ 300 ], reduced neuroinflammation and neurological injury, and improved motor function. In general, formulating antioxidants in nanocarriers has enhanced their efficacy due to better stability and/or improved transport to the CNS than free antioxidants [ 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 ]. Nanocurcumin has been evaluated as an add-on therapy to Riluzole in a pilot randomized clinical trial for safety and efficacy in ALS [ 272 ] and AD patients as dietary supplements [ 274 ].…”

Section: Antioxidant-based Nanotherapymentioning

confidence: 99%

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

et al. 2022

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Free radicals are formed as a part of normal metabolic activities but are neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This redox balance is disrupted in certain neuropathophysiological conditions, causing oxidative stress, which is implicated in several progressive neurodegenerative diseases. Following neuronal injury, secondary injury progression is also caused by excessive production of free radicals. Highly reactive free radicals, mainly the reactive oxygen species (ROS) and reactive nitrogen species (RNS), damage the cell membrane, proteins, and DNA, which triggers a self-propagating inflammatory cascade of degenerative events. Dysfunctional mitochondria under oxidative stress conditions are considered a key mediator in progressive neurodegeneration. Exogenous delivery of antioxidants holds promise to alleviate oxidative stress to regain the redox balance. In this regard, natural and synthetic antioxidants have been evaluated. Despite promising results in preclinical studies, clinical translation of antioxidants as a therapy to treat neurodegenerative diseases remains elusive. The issues could be their low bioavailability, instability, limited transport to the target tissue, and/or poor antioxidant capacity, requiring repeated and high dosing, which cannot be administered to humans because of dose-limiting toxicity. Our laboratory is investigating nanoparticle-mediated delivery of antioxidant enzymes to address some of the above issues. Apart from being endogenous, the main advantage of antioxidant enzymes is their catalytic mechanism of action; hence, they are significantly more effective at lower doses in detoxifying the deleterious effects of free radicals than nonenzymatic antioxidants. This review provides a comprehensive analysis of the potential of antioxidant therapy, challenges in their clinical translation, and the role nanoparticles/drug delivery systems could play in addressing these challenges.

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“…The number of living ies until 10 days. Around 60 ies per group were included in the survival data and the total number of ies' represents the data were expressed as percentage of surviving ies [27].…”

Section: Survival Percentagementioning

confidence: 99%

Datura Stramonium leaves extract Silver Nanoparticles regulates PINK1 gene in Parkinson’s disease model of Drosophila melanogaster

Devaraju

Gopinath

Hanumanthappa

et al. 2022

Preprint

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In recent years, several eco-friendly processes for the synthesis of silver nanoparticles (AgNPs) are increasing; they have tremendous applications in the field of diagnosis and therapeutic values for various diseases /disorders. In this article the green synthesis of Datura stramonium leaves extract silver nanoparticles (DS-AgNPs) was carried out and are characterized for different properties like reduction of Ag + to Ag◦, absorption maxima, functional group of secondary metabolites, crystalline structure, morphology, and size by using UV-Vis spectroscopy, fourier transform infrared spectroscopy (FITR) X-ray spectroscope (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM) respectively. Further the effects of DS-AgNPs on WT Park TM3 SB and WI Park 25 Parkinson’s mutant Drosophila melanogaster was assessed by the Negative geotaxis assay and PINK 1 gene expression. Treatment with DS-AgNPs exhibited increased geotaxis behavior and with a positive survival percentage, finally PINK1 was found to be down regulated as the treatment concentrations increased in WI Park 25 mutant but up regulated in WT Park TM3 SB mutant PD model. Although more molecular mechanism needs to be understood, however the use of DS-AgNPs can be a promising treatment strategy for the PD.

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Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators

Cited by 32 publications

References 63 publications

Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Advances in Research on Natural Distribution, Biosynthesis, Detection, Bioactivity, and Application of Lutein

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Datura Stramonium leaves extract Silver Nanoparticles regulates PINK1 gene in Parkinson’s disease model of Drosophila melanogaster

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