Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoniinfection in Kenyan children

Booth, Mark; Vennervald, Birgitte J.; Butterworth, Anthony E.; Kariuki, H. Curtis; Amaganga, Clifford; Kimani, Gachuhi; Mwatha, Joseph K.; Otedo, Amos; Ouma, John H.; Dunne, David W.

doi:10.1186/1741-7015-2-36

Cited by 30 publications

(27 citation statements)

References 23 publications

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“…Torben and Hailu [86] stated that increased level of this inflammatory cytokine after egg excretion may be an indication of its effect in complications of schistosomiasis, it capable of inducing tissue injury and fibrosis through inducing ROS production, lipid peroxidation [87], collagen synthesis other fibrogenic risk factors [88]. …”

Section: Discussionmentioning

confidence: 99%

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

Metwally

Ali

Mohamed

et al. 2011

Cancer Cell International

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Background/ObjectiveBladder cancer is the commonest type of malignant tumors as a result of schistosomaisis which is a major healthy problem in many subtropical developing countries. The aim of this study is to comparatively elucidate the underlying biochemical tumor markers in schistosomal bladder cancer versus non-schistosomal bladder cancer when compared to normal healthy ones.MethodsThis work was performed on tissue specimens from total 25 patients and serum samples from total 30 patients versus ten healthy individuals served as control. The investigated parameters in serum are: xanthine oxidase (XO), fructosamine, lactate dehydrogense (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total proteins, essential and non- essential amino acids profile, hydroxyproline, total immunoglobulin E (IgE) and tumor necrosis factor alpha (TNF-α). In addition, the current investigation also extended to study some markers in tumor bladder tissues including, pyruvate kinase enzyme (PK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT).ResultsResults showed that biharzial bladder cancer patients recored more significant elevation in serum XO, fructosamine, LDH, AST, ALT, hydroxyproline, IgE and TNF-α than in bladder cancer patients when compared to control ones. While, in tissues there were significant increase in PK, LDH, AST & ALT activities of schistosomal bladder cancer than in bladder cancer as compared to control healthy patients.ConclusionsIt could be concluded that, bilharzial and non-bilharzial bladder cancer showed distinct biochemical profile of tumor development and progression which can be taken into consideration in diagnosis of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

Metwally

Ali

Mohamed

et al. 2011

Cancer Cell International

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“…Meanwhile several studies reported geohelminths as worms or helminths and performed statistical analysis using helminth as variable. Using this generic definition, several studies reported a worsening effect of helminths on malaria incidence [35] and malaria-related diseases such as anemia [36][37][38] splenomegalia [31] and severe malaria [39], as well as negative birth outcomes [40]. Others studies contradicted the previous one by reporting an improvement of malaria-associated anemia during acute P. vivax malaria in Brazil [41], malaria infection [34] and malaria-associated anemia in school children [37] and severe malaria [42,43].…”

Section: Interaction Of Helminths and Malariamentioning

confidence: 95%

“…At a clinical level, S. mansoni seems to potentiate the pathogenic effect of malaria in a coendemic area [30 & ]. Conversely to S. mansoni, S. hematobium was reported to induce a different effect and hence has been reported to protect against malaria parasite densities in paucigravid women [31] and against malaria attacks in Malian and Senegalese school children [31][32][33][34].…”

Section: Schistosomiasis Interaction With Malariamentioning

confidence: 97%

Epidemiology of malaria and helminth interaction

Adegnika

Kremsner

2012

Current Opinion in HIV and AIDS

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Hookworm, A. lumbricoides and Schistosoma species were found to associate differently with malaria, which might explain the conflicting reports on interaction between helminths and malaria. It is therefore important to further investigate these three major helminths in relation to malaria, using universally accepted 'gold standard' study designs, which would be able to clearly define the nature of the interaction between malaria and helminth species. A better understanding of helminths and malaria coinfection may strengthen malaria control programmes in coendemic areas.

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“…Schistosomiasis is the most important human helminth infection in terms of morbidity and mortality; a recent meta-analysis assigned 2 to 15% disability weight to the disease (78). There is also emerging evidence that schistosome infections may impact the etiology and transmission of human immunodeficiency virus/AIDS (HIV/AIDS) (22,23,72,73,80), tuberculosis (23,(42)(43)(44), and malaria (14,19,39,96,119,153), and vice versa. In particular, the possible interaction between schistosomiasis and HIV/ AIDS is receiving increasing attention, given the role of immune responses in both diseases and the geographic overlap in distribution; low CD4 ϩ T-cell counts resulting from HIV infection may increase susceptibility to schistosome infection and influence egg excretion (54,56,74).…”

Section: Introductionmentioning

confidence: 99%

Current Status of Vaccines for Schistosomiasis

2008

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SUMMARY Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality. Infection follows direct contact with freshwater harboring free-swimming larval (cercaria) forms of the parasite. Despite the existence of the highly effective antischistosome drug praziquantel (PZQ), schistosomiasis is spreading into new areas, and although it is the cornerstone of current control programs, PZQ chemotherapy does have limitations. In particular, mass treatment does not prevent reinfection. Furthermore, there is increasing concern about the development of parasite resistance to PZQ. Consequently, vaccine strategies represent an essential component for the future control of schistosomiasis as an adjunct to chemotherapy. An improved understanding of the immune response to schistosome infection, both in animal models and in humans, suggests that development of a vaccine may be possible. This review considers aspects of antischistosome protective immunity that are important in the context of vaccine development. The current status in the development of vaccines against the African (Schistosoma mansoni and S. haematobium) and Asian (S. japonicum) schistosomes is then discussed, as are new approaches that may improve the efficacy of available vaccines and aid in the identification of new targets for immune attack.

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Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoniinfection in Kenyan children

Cited by 30 publications

References 23 publications

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients

Epidemiology of malaria and helminth interaction

Current Status of Vaccines for Schistosomiasis

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