Exposure to manganese during sertoli cell formation and proliferation disturbs early testicular development in rats

Gomes-Silva, Adriano; Medeiros, Paloma da Cunha de; Silva, Laíza Maria Jesus; Santiago, Marcella da Silva Araújo; Perobelli, Juliana Elaine

doi:10.1016/j.reprotox.2023.108447

Reproductive Toxicology

2023

DOI: 10.1016/j.reprotox.2023.108447

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Exposure to manganese during sertoli cell formation and proliferation disturbs early testicular development in rats

Adriano Gomes-Silva¹,

Paloma da Cunha de Medeiros²,

Laíza Maria Jesus Silva³

et al.

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2024

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Cited by 2 publications

References 107 publications

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GIS-based assessment of groundwater vulnerability to heavy metal contamination via water quality pollution indices in urban Aligarh, India

Badar,

Ali,

Daniyal

et al. 2024

Water Practice &Amp; Technology

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The study presents an assessment of groundwater vulnerability due to heavy-metal contamination using Heavy Metal Pollution and Contamination Index of Urban Aligarh. Globally, hazardous compounds in industrially contaminated sites are pressing and high-priority issue. A detailed risk assessment was carried out to determine the potential health hazards linked to locations that were recently polluted. A total of 17 groundwater samples were taken from hand-pump and 20 industrial drainage samples were collected from selected areas of Aligarh. The concentration of heavy-metals in the collected samples analyzed were shown on maps using ArcGIS software and interpreted for Heavy Metal Pollution Index (HPIx) and Contamination Index (CDx). These analyzed values were subsequently compared with the permissible limits established by the agencies like EPA, WHO, and BIS. The mean concentration of heavy-metals in groundwater of different locations was observed as follows particular sequence: Ni (1.40), Cu (0.58), Zn (0.06), Fe (0.08), Mn (0.04), Cr (0.001), Pb (0.00025) mg/l. Additionally in industrial effluent, Cr (18.3), Ni (13.34), Mn (1.16), Cu (1.99), Pb (1.2), Fe (6.3), Zn (0.51) mg/l. According to HPIx, the analysis reveals 64.7%, of visited areas belonged to have safe groundwater. Conversely, a smaller proportion, 35.3%, was found falling into heavy metal-polluted group.

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GIS-based assessment of groundwater vulnerability to heavy metal contamination via water quality pollution indices in urban Aligarh, India

Badar,

Ali,

Daniyal

et al. 2024

Water Practice &Amp; Technology

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ZIP8 Is Upregulated in the Testis of Zip14-/- Mice

Vungutur,

McCabe,

Zhao

2024

Nutrients

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Background/Objectives: Manganese is an essential nutrient involved in various biological processes, including reproductive health, yet the mechanisms regulating its homeostasis in the testis remain poorly understood. Methods and Results: In this study, we investigated the expression and regulation of key manganese transporters—ZIP8, ZIP14, and ZnT10—in mouse testes. Immunoblotting analyses revealed that ZIP8 is expressed in the testes, while ZIP14 and ZnT10 were undetectable. Using Zip14 knockout (Zip14-/-) mice, which exhibit systemic manganese overload, we discovered a significant increase in manganese levels in the testis, accompanied by an upregulation of ZIP8. Importantly, the levels of other essential metals, such as iron, zinc, and copper, remained unchanged. Conclusions: Our findings suggest that ZIP8 plays a critical role in manganese transport in the testis, and its increased expression may contribute to manganese accumulation in the absence of ZIP14. This study advances our understanding of manganese homeostasis in the testis and its potential impact on male reproductive health.

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Exposure to manganese during sertoli cell formation and proliferation disturbs early testicular development in rats

Cited by 2 publications

References 107 publications

GIS-based assessment of groundwater vulnerability to heavy metal contamination via water quality pollution indices in urban Aligarh, India

GIS-based assessment of groundwater vulnerability to heavy metal contamination via water quality pollution indices in urban Aligarh, India

ZIP8 Is Upregulated in the Testis of Zip14-/- Mice

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