Exposure to metals and congenital anomalies: A biomonitoring study of pregnant Bedouin-Arab women

Karakis, Isabella; Landau, Daniella; Yitshak‐Sade, Maayan; Hershkovitz, Reli; Rotenberg, Michal; Sarov, Batia; Grotto, Itamar; Novack, Lena

doi:10.1016/j.scitotenv.2015.02.056

Cited by 20 publications

(19 citation statements)

References 24 publications

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“…Since perinatal and postnatal exposure to tobacco smoke has been found to be associated with infant’s respiratory morbidity, this lack of information may bias our results. However, previous studies that assessed the quantity of tracers of cigarettes smoking (cadmium and cotinine) in pregnant Arab women, found that they appear the least exposed to passive smoking, and that these tracers had very low concentrations in this population [ 9 , 49 ]. Likewise, the information on open fire cooking rates in the Arab-Bedouin population was not available from medical databases and therefore could not be included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately half of the Arab-Bedouin population lives in temporary settlements that cannot be hermetically sealed from outdoor pollutants and therefore is more likely to be exposed to and affected by them. These different lifestyles, coupled with the lower socioeconomic status create the difference between the two populations and has a potential to modify the environmental effects on health [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life

et al. 2020

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Background: Lower respiratory tract infections (LRTI) in early life, including pneumonia, bronchitis and bronchiolitis, can lead to decreased lung function, persistent lung damage and increased susceptibility to various respiratory diseases such as asthma. In-utero exposure to particulate matter (PM) during pregnancy may disrupt biological mechanisms that regulate fetal growth, maturation and development. We aimed to estimate the association between intrauterine exposure to PM of size < 2.5 μm in diameter (PM 2.5) and incidence of LRTIs during the first year of life. Methods: A retrospective population-based cohort study in a population of mothers and infants born in Soroka University Medical Center (SUMC) in the years 2004-2012. All infants < 1 year old that were hospitalized due to LRTIs were included. The main exposure assessment was based on a hybrid model incorporating daily satellite-based predictions at 1 km 2 spatial resolution. Data from monitoring stations was used for imputation of main exposure and other pollutants. Levels of environmental exposures were assigned to subjects based on their residential addresses and averaged for each trimester. Analysis was conducted by a multivariable generalized estimating equation (GEE) Poisson regression. Data was analyzed separately for the two main ethnic groups in the region, Jewish and Arab-Bedouin. Results: The study cohort included 57,331 deliveries that met the inclusion criteria. Overall, 1871 hospitalizations of infants < 1 year old due to pneumonia or bronchiolitis were documented. In a multivariable analysis, intrauterine exposure to high levels of PM 2.5 (> 24 μg/m 3) in the first and second trimesters was found to be adversely associated with LRTIs in the Arab-Bedouin population (1st trimester, RR = 1.31, CI 95% 1.08-1.60; 2nd trimester: RR = 1.34, CI 95% 1.09-1.66). Conclusion: Intrauterine exposure to high levels of PM 2.5 is associated with a higher risk of hospitalizations due to lower respiratory tract infections in Arab-Bedouin infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life

et al. 2020

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“…There is growing evidence about adverse obstetrical outcomes linked with in utero exposure to environmental contaminants such as spontaneous abortion, delayed fetal growth, premature birth, congenital malformations and impaired neural and cognitive development [2,3,4,5,6,7,8,9]. The International Federation of Gynecology and Obstetrics (FIGO) now recognizes these adverse health outcomes linked with prenatal exposure to environmental chemicals [1].…”

Section: Introductionmentioning

confidence: 99%

Perception of Environmental Risks and Health Promotion Attitudes of French Perinatal Health Professionals

Marie

Lémery

Vendittelli

et al. 2016

IJERPH

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The exposure of pregnant women to environmental contaminants is a subject of international concern. However, the risk perception of these contaminants by health professionals (HP) has not been extensively investigated. The main objective of the PERI–HELPE study (Perception of Risk–HEaLth Professionals & Environment Study) was to assess the risk perception of environmental exposure of pregnant women by perinatal HPs. The secondary objectives were to describe the preventive attitudes of perinatal HPs concerning chemicals exposure of pregnant women and to identify the barriers to preventive attitude. A cross-sectional study was performed in 2015 in France. One hundred eighty-nine HPs (obstetricians, midwives, and general practitioners) replied to an online self-administered questionnaire (participation rate: 11%). Carbon monoxide, pesticides and lead were the contaminants most frequently perceived as a high risk for pregnant women. A minority of HPs asked women about their chemical exposure and advised them to reduce exposure. The lack of information, training and scientific evidence in environmental health were the main difficulties declared by the HPs to advise pregnant women. Despite the low response rate, our findings provide important information to encourage French health authorities to take into account the difficulties encountered by HPs and set up appropriate training programs in Environmental health.

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“…From the environmental aspect, a study performed on pregnant Arab-Bedouin women in southern Israel investigated the relationship between air pollution and congenital malformations, and found that patients with high levels of aluminum had more infants with minor malformations, with cardiovascular defects being the most prevalent. 29 Additional environmental studies focussing specifically on CHDs could help clarify this relationship.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for congenital heart defects in two populations residing in the same geographic area: a long-term population-based study, Southern Israel

et al. 2019

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Background:Congenital Heart Defects (CHD) are the most common structural defects of newborns. Southern Israel’s population is comprised of Jews (75%) and Arab-Bedouins (25%). The latter has a high rate of consanguinity and low abortion rate compared with the Jewish population, which led us to suspect a higher CHD prevalence in this population. Our aim was to compare maternal risk factors that are associated with CHD in these populations.Methods:All births during 1991–2011 in Soroka University Medical Center (n = 247, 289) with 6078 newborns having CHD were included. To account for same-woman deliveries, general estimating equation models adjusted for ethnicity, gender and birth number were used.Results:The total prevalence of CHD was 24.6/1000 live births, with 21.4 and 30 among Jewish and Bedouin populations, respectively, (p = 0.001). Multi-variant analysis of risk factors for CHD revealed that risk factors common to both populations included conception with fertility medications, sibling CHD, maternal CHD, diabetes mellitus, hypertension and anaemia. Risk factors that were specific for the Bedouin population were – maternal age over 35 years, recurrent pregnancy loss and in vitro fertilisation. However, sibling CHD was more common as a CHD risk factor in the Jewish compared with the Bedouin population (Adjusted OR 10.23 versus 3.19, respectively).Conclusions:The prevalence of CHD is higher in both the Bedouin and Jewish populations than previously reported. Several maternal factors were associated with CHD specifically for a certain population. Risk factors for CHD vary in populations residing in the same geographic area.

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Exposure to metals and congenital anomalies: A biomonitoring study of pregnant Bedouin-Arab women

Cited by 20 publications

References 24 publications

The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life

The effect of exposure to particulate matter during pregnancy on lower respiratory tract infection hospitalizations during first year of life

Perception of Environmental Risks and Health Promotion Attitudes of French Perinatal Health Professionals

Risk factors for congenital heart defects in two populations residing in the same geographic area: a long-term population-based study, Southern Israel

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