Exposure to multiple pyrethroid insecticides affects ovarian follicular development via modifying microRNA expression

Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries

“…Although in vitro and animal studies have demonstrated that exposure to pyrethroids may affect ovarian function, the available evidence of the consequences of chronic exposure to these insecticides on long-term female reproductive health outcomes in animals and humans remains limited. A very recent study using mice provided the first demonstration of the effect of gestational exposure to pyrethroids on the ovaries of female offspring in adulthood [ 16 ]. That study showed irreversible adverse effects on the fertility of mouse offspring, including a significant decrease in the number of primary follicles and significant increases in the number of atretic follicles and granulosa cell apoptosis [ 16 ].…”

“…A very recent study using mice provided the first demonstration of the effect of gestational exposure to pyrethroids on the ovaries of female offspring in adulthood [ 16 ]. That study showed irreversible adverse effects on the fertility of mouse offspring, including a significant decrease in the number of primary follicles and significant increases in the number of atretic follicles and granulosa cell apoptosis [ 16 ]. However, the mentioned study used a mixture of eight pyrethroids (fenvalerate, λ-cyhalothrin, fenpropathrin, deltamethrin, cyfluthrin, cypermethrin, permethrin and bifenthrin) that did not include allethrin, which is one of the most commonly used pyrethroids.…”

Degradation strategies of pesticide residue: From chemicals to synthetic biology

“…Besides, strong evidence proves that pyrethroid is also a thyroid hormone disruptor and has the hormone-like activity to interfere with reproduction [ 49 ]. Except for the endocrine way, pyrethroids can modify the expression of ovarian miRNAs to interfere with ovarian development and maturation more directly [ 50 ]. Moreover, the impact on reproduction can't be ignored in aquatic animals caused by water-soluble pesticides.…”

Atmospheric transport of particulate matter and particulate-bound agrochemicals from beef cattle feedlots: human health implications for downwind agricultural communities

“…Further epidemiological evidence of pyrethroid association with blood cancer precursors (MGUS; Hofmann et al, 2021) have since been reported. In concert with more recent prenatal in vivo studies (Priyanka et al, 2022;Song et al, 2022), conflicting conclusions on the weight of epidemiological evidence for health outcomes in children (Andersen et al, 2022), and prevalent incidences of acute permethrin exposure, the supporting literature for carcinogenic, reproductive, and neurodevelopmental pyrethroid risk to children deserves significantly greater regulatory consideration. or reproduced as such.…”

“…Chronic exposure has been linked to primary ovarian insufficiency in Chinese women (Li et al, 2018) and male rat reproductive disfunction (oral; low total mixture dose = 0.0006 mg/kg/day, high total mixture dose = 0.0031 mg/kg/day; Ravula & Yenugu, 2021), including changes in fecundity and testicular genotoxicity (total mixture dose (oral) = 0.016 mg/kg/day; Priyanka et al, 2022). Prenatal exposure to pyrethroid mixtures is associated with adverse effects on human neurodevelopment (thyroid hormone function; Andersen et al, 2022), and irreversible adverse effects on follicular development and ovarian function in female rat offspring (total mixture dose (rat, oral) = 0.2 mg/kg/day; Song et al, 2022).…”