Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer

Zhang, Hua; Zhang, Renwen; Zeng, Xujia; Xiao, Wang; Wang, Desheng; Jia, Hongling; Xu, Weiguo; Gao, Yunfei

doi:10.1016/j.envres.2022.112703

Cited by 50 publications

(28 citation statements)

References 72 publications

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“…22 No earlier study reported the toxicity of conjugated NEOs in humans, and the available reports are all based on the toxicity of NEOs_ free or NEOs _total . 9,22 Our results suggested that IMI_ conjugated , DIN_ conjugated , and 5-OH-IMI_ conjugated contribute to DNA damage in humans in comparison with those of IMI_ free , DIN_ free , and 5-OH-IMI_ free , respectively. Several studies have presented evidence that conjugated forms of chemicals may elicit greater toxicity.…”

Section: Associations Between Oxidative Stress and Serum Neos Levelsmentioning

confidence: 71%

“…5−8 A recent study reported that NEO metabolites (m-NEOs) may increase the prevalence of liver cancer. 9 NEOs and their metabolites can pass through the human placenta and may accumulate in the fetus. 10 In vivo studies have found that some NEOs affect mammalian reproductive health, from decreased sperm quality in males and infertility in females as well as increased embryonic lethality and preterm birth.…”

Section: ■ Introductionmentioning

confidence: 99%

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Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress

et al. 2023

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Following exposure, neonicotinoid insecticides (NEOs) can be metabolized by both Phase I and Phase II reactions catalyzed by human cytochrome P450 enzymes. However, toxicities of parent NEOs and their metabolites are still unclear, and little is known about biotransformation rates and pathways of NEOs in humans. In this study, 98 serum samples collected in China were analyzed for free, conjugated and total forms of six parent NEOs (i.e., acetamiprid (ACE), imidacloprid (IMI), clothianidin (CLO), thiacloprid (THD), thiamethoxam (THM), and dinotefuran (DIN)) and four metabolites (i.e., N-desmethyl-acetamiprid (N-dm-ACE), 1-methyl-3-(tetrahydro-3-furylmethyl) (DIN-U), 5-hydroxy-imidacloprid (5-OH-IMI), olefin-imidacloprid (Of-IMI)). NEOs and their metabolites were detected in all serum samples, and the total median concentrations of free, conjugated, and total forms of 10 NEOs were 2.04, 2.01, and 5.12 ng/mL, respectively. Conjugated forms of NEOs accounted for only half (53%) of the total forms of NEOs. Based on the profiles of Phase I and Phase II metabolites of NEOs in serum, it was found that age is a determinant in Phase I metabolism of DIN and Phase II metabolism of IMI. The Phase II metabolites of NEOs are associated with oxidative DNA damage, and the conjugated forms of IMI, DIN, and 5-OH-IMI in serum were significantly positively correlated with oxidative stress. Overall, the amount of NEOs present in conjugated forms in human serum was determined to document the existence of a considerable proportion of free forms of these insecticides.

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Section: Associations Between Oxidative Stress and Serum Neos Levelsmentioning

confidence: 71%

Section: ■ Introductionmentioning

confidence: 99%

Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress

et al. 2023

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“…For example, Xu et al reported the occurrence of p-NEOs and m-NEOs in whole blood samples collected from Chinese university students (aged 20–27 years), with median concentrations ranging from 0.08 (THM) to 0.78 (of-IMI) ng/mL . High levels of NEOs were also found in the serum of elderly people (>50 years) and the general population (22–91 years) in South China. The median concentrations of NEOs in MS collected in this study were comparable to those reported in the above three studies on blood levels of NEOs in the general population of Guangdong province, ,, but the detection frequencies of NEOs were all below 50% in the serum of Chinese residents living in Jiangsu Province .…”

Section: Resultsmentioning

confidence: 99%

“…22 High levels of NEOs were also found in the serum of elderly people (>50 years) 25 and the general population (22−91 years) 55 in South China. The median concentrations of NEOs in MS collected in this study were comparable to those reported in the above three studies on blood levels of NEOs in the general population of Guangdong province, 20,25,55 but the detection frequencies of NEOs were all below 50% in the serum of Chinese residents living in Jiangsu Province. 56 Chinese National Bureau of Statistics reported in 2014 that pesticides usage in Guangdong was nearly twofold higher than that in Jiangsu, thus the variation in serum levels of NEOs among the Chinese population may be partly due to the differences in pesticides usage between geographic regions.…”

Section: Chemicals Andmentioning

confidence: 99%

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Zhang

Bai

Zhang

et al. 2022

Environ. Sci. Technol.

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Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, and transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) and their metabolites (m-NEOs) were determined in 95 paired maternal (MS) and cord serum (CS) samples collected in southern China. Imidacloprid was the predominant p-NEO in both CS and MS samples, found at median concentrations of 1.84 and 0.79 ng/mL, respectively, whereas N-desmethylacetamiprid was the most abundant m-NEO in CS (median: 0.083 ng/mL) and MS (0.13 ng/mL). The median transplacental transfer efficiencies (TTEs) of p-NEOs and m-NEOs were high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefinimidacloprid, of-IMI), indicating efficient placental transfer of these insecticides. Moreover, transplacental transport of NEOs appears to be passive and structuredependent: cyanoamidine NEOs such as acetamiprid and thiacloprid had higher TTE values than the nitroguanidine NEOs, namely, clothianidin and THM. Multilinear regression analysis revealed that the concentrations of several NEOs in MS were associated significantly with hematological parameters related to hepatotoxicity and renal toxicity. To our knowledge, this is the first analysis of the occurrence and distribution of NEOs in paired maternal−fetal serum samples.

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“…However, organophosphorus and neonicotinoid insecticides in closed environments, such as greenhouses, have been associated with occupational diseases in greenhouse workers exposed to them [55,56] and damage from pollinating insects such as bees [57].…”

Section: Introductionmentioning

confidence: 99%

Bio-Insecticidal Potential of Tangerine Peel Oil Against Greenhouse Whitefly: A Green Biopesticide Candidate

Flores-Mediavilla¹,

Prado-Beltrán²,

Espín-Valladares³

et al. 2023

Preprint

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The excessive use of synthetic insecticides in modern agriculture has led to the contamination of the environment and the development of insect resistance. In this study, we evaluated the potential of tangerine (Citrus reticulata L.) peel essential oil (EO) as a natural insecticide against greenhouse whitefly (Trialeurodes vaporariorum W. (Homoptera: Aleyrodidae)), a common pest in greenhouse production. Petroleum ether (PET) and n-hexane (HEX) were used as solvents to extract essential oil (EO) from tangerine peels. The yield of EO was 1.59 % and 2.00 % (m/m) for PET and HEX, respectively. The insecticidal activity of EO was evaluated by measuring the mortality rate (MR) of greenhouse whiteflies at different time intervals. The results showed that PET and HEX extracts of tangerine EO effectively controlled the greenhouse whitefly. With both solvents, it was observed that with doses of 12.5% (v/v), similar results were achieved as with the positive control (corresponding to the commercial insecticide imidacloprid). Additionally, the FTIR analysis found that the EO contained d-limonene, which may be the source of its insecticidal properties. Therefore, tangerine peel essential oil is an excellent natural insecticide candidate for controlling greenhouse whiteflies effectively and sustainably.

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Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer

Cited by 50 publications

References 72 publications

Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress

Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Bio-Insecticidal Potential of Tangerine Peel Oil Against Greenhouse Whitefly: A Green Biopesticide Candidate

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