2023
DOI: 10.1002/tox.24055
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Exposure to nickel chloride induces epigenetic modification on detoxification enzyme glutathione S‐transferase M2

Yu‐Ting Kang,
Wan‐Jung Yang,
Hsu Chih Huang
et al.

Abstract: Nickel (Ni) is a human carcinogen with genotoxic and epigenotoxic effects. Environmental and occupational exposure to Ni increases the risk of cancer and chronic inflammatory diseases. Our previous findings indicate that Ni alters gene expression through epigenetic regulation, specifically impacting E‐cadherin and angiopoietin‐like 4 (ANGPTL4), involved in epithelial‐mesenchymal transition and migration. GST‐M2, a member of the glutathione S‐transferase (GST) enzyme family, plays a crucial role in cellular def… Show more

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