Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice

Locker, Alicia Revitsky; Marks, Michael J.; Kamens, Helen M.; Klein, Laura Cousino

doi:10.1016/j.brainresbull.2015.09.009

Cited by 20 publications

(26 citation statements)

References 84 publications

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“…Brief pretreatment of male rats during early adolescence (P28–31) with low doses of nicotine enhances subsequent acquisition of alcohol self-administration (21). Periadolescent nicotine (P35–44) also enhances ethanol consumption in female mice (134), although one study reported no effect of adolescent nicotine exposure in rats on ethanol intake in adulthood (135). The discrepancy may be due to different age of testing for ethanol consumption or continuous versus intermittent exposure paradigms.…”

Section: Concurrent Use Of Nicotine and Alcoholmentioning

confidence: 99%

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Cross

Lotfipour

Leslie

2016

The American Journal of Drug and Alcohol Abuse

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Concurrent use of tobacco and alcohol or psychostimulants represents a major public health concern, with use of one substance influencing consumption of the other. Co-abuse of these drugs leads to substantial negative health outcomes, reduced cessation, and high economic costs, but the underlying mechanisms are poorly understood. Epidemiological data suggest that tobacco use during adolescence plays a particularly significant role. Adolescence is a sensitive period of development marked by major neurobiological maturation of brain regions critical for reward processing, learning and memory, and executive function. Nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. In this review, we discuss recent clinical and preclinical data examining the genetic factors and mechanisms underlying co-use of nicotine and alcohol or cocaine and amphetamines. We evaluate the critical role of nicotinic acetylcholine receptors throughout, and emphasize the dearth of preclinical studies assessing concurrent drug exposure. We stress important age and sex differences in drug responses, and highlight a brief, low-dose nicotine exposure paradigm that may better model early use of tobacco products. The escalating use of e-cigarettes among youth necessitates a closer look at the consequences of early adolescent nicotine exposure on subsequent alcohol and drug abuse.

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Section: Concurrent Use Of Nicotine and Alcoholmentioning

confidence: 99%

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Cross

Lotfipour

Leslie

2016

The American Journal of Drug and Alcohol Abuse

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“…In contrast, [23] observed that female adolescent mice (PND 35-41) exposed to nicotine showed increased bottle-drinking ethanol consumption on (PND [41][42][43][44]. The effects of nicotine exposure during adolescence on ethanol intake seem to depend on the treatment age, duration, strain, sex, and nicotine withdrawal period [23,40]. To our knowledge, this is the first study that has demonstrated increased operant saccharine self-administration while assessing the consequences of nicotine pretreatment during adolescence in later life.…”

Section: Discussionmentioning

confidence: 90%

“…In the same way, Smith et al [39] showed that chronic continuous exposure to nicotine during adolescence (PND 35-53) did not modify ethanol intake in adulthood (PND 54-75). In contrast, [23] observed that female adolescent mice (PND 35-41) exposed to nicotine showed increased bottle-drinking ethanol consumption on (PND [41][42][43][44]. The effects of nicotine exposure during adolescence on ethanol intake seem to depend on the treatment age, duration, strain, sex, and nicotine withdrawal period [23,40].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to nicotine during adolescence increases the propensity for ethanol dependence in adulthood [22]. Recently, it was observed that adolescents exposed to nicotine showed increased bingelike ethanol consumption in adulthood [23]. Moreover, adolescent nicotine exposure facilitates the establishment of ethanol conditioned place preference in adult animals [24].…”

Section: Introductionmentioning

confidence: 99%

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Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

P¹,

Cruz²,

Carneiro-de-Oliveira³

et al. 2017

J Alcohol Drug Depend

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Among drugs of abuse, nicotine and alcohol are the most consumed in the world, and are often co-abused. Evidence has shown that nicotine enhances the consumption and subjective effects of ethanol. How nicotine increases alcohol consumption is an interesting question that is still left unanswered. We assessed whether repeated treatment with nicotine during adolescence or adulthood could increase operant alcohol selfadministration. Male adolescent and adult rats (postnatal day [PND] 28 and 60, respectively) were injected with nicotine (1.0 mg/kg, subcutaneously [s.c.], three times a day for 10 days). During this period, the control group received saline injections (0.1 ml/kg; s.c). On PND 72, adolescent and adult rats pretreated with nicotine were subjected to ethanol self-administration procedures. Alcohol oral self-administration patterns were evaluated using a progressive ratio schedule of reinforcement and 24-hour unlimited access to ethanol. Our results showed that nicotine pretreatment in adult rats increases the motivation for alcohol consumption. However, nicotine exposure during adolescence does not affect alcohol-consuming behaviors in adulthood.

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“…Adolescence clearly is one of the critical periods during which exposure to drug can exert life-long changes in brain and behavior. Locker et al [in this issue] show that nicotine exposure during adolescence impacts later ethanol intake in mice and the binding of nicotinic cholinergic receptors in brain. Of course, until recently, humans were rarely exposed to nicotine in the absence of numerous toxicants.…”

Section: Papers In This Mini-issue: Risk Factors For Addictionmentioning

confidence: 93%

Addiction: A preclinical and clinical analysis

Grigson

2016

Brain Research Bulletin

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Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice

Abstract: Graphical abstract

Cited by 20 publications

References 84 publications

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Exposure to Nicotine in Adult, but not Adolescent, Rats Increases Alcohol Self-Administration in Adulthood

Addiction: A preclinical and clinical analysis

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