Abstract:Rationale: Mycobacterium tuberculosis (Mtb) has a devastating impact on global health. Mtb is the causative agent of human pulmonary tuberculosis (TB), which claims 1.4 million lives per annum. During infection, differentially culturable bacilli (DCB) that fail to produce colonies on solid media but grow in liquid media supplemented with resuscitation-promoting factor (Rpf) proteins are formed. These Rpf-dependent mycobacteria are a major barrier to developing improved TB treatments and diagnostic tools.
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