Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women

Zhang, Yan; Ji, Lin; Hu, Yi; Tse, Lap Ah; Wang, Yiwen; Qin, Kaili; Ding, Guodong; Zhou, Yijun; Yu, Xiaodan; Ouyang, Fengxiu; Zhang, Jun; Gao, Yu; Tian, Ying

doi:10.1093/aje/kwz242

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…OP exposure has been monitored in human subjects, as have the effects of long-term exposure to OP [13][14][15]. Exposure of adults to OP insecticides has been linked to poor semen quality, infertility, and other reproductive problems [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Suwannarin

Prapamontol

Isobe

et al. 2020

IJERPH

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Exposure to insecticides containing organophosphate (OP) and neonicotinoid (NEO) compounds has been associated with adverse reproductive health outcomes. This study characterized and identified predictors of exposure to OP and NEO among 100 reproductive-age farmworkers from two intensive farming areas in Chiang Mai Province, Thailand, including 50 each from the Fang (FA) and Chom Thong (CT) districts. OP exposure was determined by measuring the urinary concentrations of six dialkylphosphates (DAPs), whereas NEO exposure was determined by measuring the urinary concentrations of NEO compounds and their metabolites (NEO/m). The most frequently detected OPs were diethylphosphate (DEP) and diethylthiophosphate (DETP), with DETP having the highest geometric mean (GM) concentration, 8.9 μg/g-creatinine. The most frequently detected NEO/m were N-desmethyl-acetamiprid (N-dm-ACE), imidacloprid (IMI), and thiamethoxam (THX), with IMI having the highest GM concentration, 8.7 μg/g-creatinine. Consumption of well water was the predominant determinant of OP and NEO exposure in this population. In addition to encouraging workers to use personal protective equipment, exposure of farmworkers to these compounds may be reduced by nation-wide monitoring agricultural insecticides and other pesticides in community drinking water resources.

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Section: Introductionmentioning

confidence: 99%

Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Suwannarin

Prapamontol

Isobe

et al. 2020

IJERPH

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“…The duration of bleeding is linked to obesity in some studies [47,48,73], but not in others [74]. Exposure to high concentration of organophosphate pesticides has been linked to shorter duration of bleeding [75]. Summary of factors that may be linked to the duration of bleeding is provided in Table 3.…”

Section: Bmi Rangementioning

confidence: 99%

The Duration of Menstrual Blood Loss: Historical to Current Understanding

Habiba

Benagiano

2023

Reprod. Med.

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Most published research focuses on the amount of menstrual blood loss and, to a lesser extent, on cyclicity. Little attention has been paid to the duration of bleeding, the factors that enable its cessation within a ‘normal’ timeframe, or to patterns that entail interruption and resumption of blood loss. The definition of what constitutes normal remains arbitrary and there is no therapy specifically designed to shorten the duration of bleeding. Here, we critically review the literature that addresses the duration of bleeding and the factors that trigger endometrial breakdown and repair. Available reports used population averages which mask inter- and intra-individual variations. The duration of bleeding is not necessarily linked to the amount of loss but may be influenced by age, ethnicity, habitus, region and altitude of residence, dieting and stress. The onset of bleeding has been linked to declining steroid production by the corpus luteum. There remains considerable controversy around the extent of endometrial shedding at menstruation. This is likely to vary within and between women. The significance of a change from previous patterns, very short or prolonged bleeding, days of light loss or spotting before or after days of bleeding, or of bleed-free days that punctuate flow, remain poorly understood.

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“…Di-(2-ethylhexyl) adipate can shorten the average length of the estrus cycle in rats (Wato et al 2009 ), whereas acetyl tributyl citrate has been shown to do so in mice (Rasmussen et al 2017 ). In humans, exposure to organophosphate pesticides has been related to a higher risk of irregular menstrual cycles and shorter menstrual bleed duration among Chinese women (Zhang et al 2019 ). Consumption of phytoestrogen-rich soy foods increases menstrual cycle length in healthy premenopausal women (Hooper et al 2009 ; Kumar et al 2002 ).…”

Section: Adverse Outcome Pathways As They Relate To Key Processes In mentioning

confidence: 99%

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

et al. 2020

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Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous exposure to an ever-increasing number of chemicals. The cause–effect relationships between chemical exposure and female reproductive disorders, however, have proven problematic to determine. This has made it difficult to assess the risks chemical exposures pose to a woman’s reproductive development and function. To address this challenge, this review uses the adverse outcome pathway (AOP) concept to summarize current knowledge about how chemical exposure can affect female reproductive health. We have a special focus on effects on the ovaries, since they are essential for lifelong reproductive health in women, being the source of both oocytes and several reproductive hormones, including sex steroids. The AOP framework is widely accepted as a new tool for toxicological safety assessment that enables better use of mechanistic knowledge for regulatory purposes. AOPs equip assessors and regulators with a pragmatic network of linear cause–effect relationships, enabling the use of a wider range of test method data in chemical risk assessment and regulation. Based on current knowledge, we propose ten putative AOPs relevant for female reproductive disorders that can be further elaborated and potentially be included in the AOPwiki. This effort is an important step towards better safeguarding the reproductive health of all girls and women.

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Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women

Cited by 11 publications

References 46 publications

Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

The Duration of Menstrual Blood Loss: Historical to Current Understanding

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

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