Exposure to perfluoroalkyl substances and women's fertility outcomes in a Singaporean population-based preconception cohort

Cohen, Nathan; Yao, Meizhen; Midya, Vishal; Aldana, Sandra India; Mouzica, Tomer; Andra, Syam S.; Narasimhan, S.; Meher, Anil Kumar; Arora, Manish; Chan, Jerry Kok Yen; Chan, Shiao‐Yng; Loy, See Ling; Mínguez-Alarcón, Lidia; Oulhote, Youssef; Huang, Jonathan; Valvi, Damaskini

doi:10.1016/j.scitotenv.2023.162267

Cited by 20 publications

(6 citation statements)

References 60 publications

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“…Of the participants with cytokine measurements available, 722 had su cient serum aliquots from blood collected at the same time as that used for cytokine measurements for PFAS measurements; 1 ml aliquots were sent to Mount Sinai Targeted Analysis Laboratory Hub where 9 PFAS analytes were measured: per uorooctane sulfonate total (PFOS), per uorooctanoic acid total (PFOA), per uorohexane sulfonate (PFHxS), per uorononanoic acid (PFNA), per uorohexanoic acid (PFHXA), perluoroheptanoic acid (PFHPA), per uoroheptanesulfonic acid (PFHPS), per uorodecanoic acid (PFDA), and per uroundecanoic acid (PFUNDA).Quanti cation of PFAS analytes in serum was conducted as described in Kato et al (2018) with minor modi cations. (25)(26)(27) Brie y, PFAS quanti cation was conducted with isotope-dilution liquid chromatography and tandem mass spectrometry. Initially, each sample received 13 C stable isotope labeled internal standards, then they were processed by solid-phase extraction with an Oasis WAX mixed-mode polymeric reversed-phase 96well plate (30 mg sorbent per well, 30 µm particle size; Waters Corporation, Milford, MA).…”

Section: Study Populationmentioning

confidence: 99%

“…The laboratory's internal quality control accounted for 20% of each batch. It had reagent-and matrix-based experimental blanks, matrix spikes at three different validation levels (low, medium, and high), NIST standard reference materials (SRM 1957 andSRM 1958), and archived pro ciency testing material (25,27), as outlined in Human Health Exposure Analysis Resource (HHEAR) (30). The limits of quanti cation (LOQ) for the PFAS analytes in the assay ranged from 0.3 to 0.7 ng/mL.…”

Section: Study Populationmentioning

confidence: 99%

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Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

Cauble,

Reynolds,

Epeldegui

et al. 2024

Preprint

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Background Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that have been shown to cause or are related to various health outcomes and diseases.Methods In this cross-sectional study nested in the California Teachers Study cohort, we measured PFAS exposure (9 analytes) in serum, and further evaluated the 4 PFAS analytes (PFHxS, PFNA, PFOA, PFOS) with detection levels of > 80%, in relation to 16 systemic inflammatory/immune markers in two multiplex serum-based assays from blood collected at one point in time. Study participants (n = 722) were female, completed a questionnaire regarding various health measures and behaviors, and donated a blood sample between 2013–2016. The association between PFAS analytes and immune markers (dichotomized by median) were evaluated by calculating odds ratios (OR) and 95% confidence intervals (CI), in both linear and logistic regression models, adjusted for age.Results The median age of our study population was 61 years (range = 40–95 years), of whom 99.7% had detectable levels of at least one PFAS analyte. The prevalence of PFAS analytes was strongly correlated with age, with those aged 40–49 years (youngest group) having the lowest PFAS burden and those aged 75 + years (oldest group) with the highest detectable levels. Statistically significant positive associations were observed between each ng/mL increase in PFHxS (OR = 1.34), PFOA (OR = 1.15), and PFOS (OR = 1.53) levels with BAFF levels above the median (compared to below the median). There was a 1.47-fold increase of elevated PFHxS with TNF-RII (above median) and a 1.38-fold increase with IL2Rα. We observed statistically significant inverse associations between PFOA and IL6 (OR = 0.79), and between PFNA with sCD14 (OR = 0.86) and CD27 (OR = 0.80). Risk estimates for logistic regression models were consistent. No significant positive associations were observed between PFNA exposure and any immune marker.Conclusions PFAS exposure was associated with altered levels of circulating inflammatory/immune markers. If validated, our results may suggest potential immune mechanisms underlying associations between the different PFAS analytes and adverse health outcomes.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

Cauble,

Reynolds,

Epeldegui

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

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“…A critical time of embryo development is the period between zygote and blastocyst ( Figure 7 ). P4 impacts the endometrial lining by stimulating the final differentiation and secretory functions and P4 antagonists impact fertility by inhibiting ovulation and directly affecting the endometrium [ 72 , 73 ]. This occurs in preparation for implantation during the luteal phase.…”

Section: Effects On Embryo Pre-implantationmentioning

confidence: 99%

How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature

Lockington,

Favetta

2024

JoX

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There has been emerging research linking per- and poly-fluoroalkyl substances (PFAS) to gamete viability and fertility. PFAS, prevalent in the environment and water supplies, undergo slow degradation due to their C-F bond and a long half-life (2.3–8.5 years). In females, PFAS inhibit the hypothalamic–pituitary–gonadal (HPG) axis, reducing follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, leading to the inhibition of androgen and estradiol production. PFAS have been found to cause detrimental effects on egg quality through impairing folliculogenesis. In males, PFAS can impair sperm motility and morphology: two fundamental qualities of successful fertilization. PFAS exposure has been proven to inhibit testosterone production, sperm capacitation, and acrosomal reaction. After fertilization, the results of PFAS exposure to embryos have also been investigated, showing reduced development to the blastocyst stage. The aim of this review is to report the main findings in the literature on the impact of PFAS exposure to gamete competency and fertilization capability by highlighting key studies on both male and female fertility. We report that there is significant evidence demonstrating the negative impacts on fertility after PFAS exposure. At high doses, these environmentally abundant and widespread compounds can significantly affect human fertility.

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“…Subsequent studies have found that higher concentrations of PCBs and pesticides in FF are associated with thinner endometrial thickness, reduced numbers of retrieved oocytes, and decreased fertilization rates in intracytoplasmic sperm injection procedures ( 195 ). Self-reported lifestyle factors and EDCs concentrations in FF have shown that the presence of PFAS increases ovarian sensitivity to hormone stimulation while reducing embryo quality and fertility ( 196 , 197 ), especially preconception exposure ( 198 ). In vitro models examining the effects of DES on the human ovarian cortex provide compelling evidence that it decreases the density of unilaminar follicles and negatively impacts fertility ( 199 ).…”

Section: Introductionmentioning

confidence: 99%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation and changes in lifestyle, the occurrence of these diseases is closely connected to exposure to harmful substances in the environment. Endocrine disrupting chemicals (EDCs), characterized by hormone-like effects, have a wide range of influences on the reproductive system. EDCs are ubiquitous in the natural environment and are present in a wide range of industrial and everyday products. Currently, thousands of chemicals have been reported to exhibit endocrine effects, and this number is likely to increase as the testing for potential EDCs has not been consistently required, and obtaining data has been limited, partly due to the long latency of many diseases. The ability to avoid exposure to EDCs, especially those of artificially synthesized origin, is increasingly challenging. While EDCs can be divided into persistent and non-persistent depending on their degree of degradation, due to the recent uptick in research studies in this area, we have chosen to focus on the research pertaining to the detrimental effects on reproductive health of exposure to several EDCs that are widely encountered in daily life over the past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, and so on. By focusing on the impact of EDCs on the hypothalamic-pituitary-gonadal (HPG) axis, which leads to the occurrence and development of reproductive system diseases, this review aims to provide new insights into the molecular mechanisms of EDCs’ damage to human health and to encourage further in-depth research to clarify the potentially harmful effects of EDC exposure through various other mechanisms. Ultimately, it offers a scientific basis to enhance EDCs risk management, an endeavor of significant scientific and societal importance for safeguarding reproductive health.

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Exposure to perfluoroalkyl substances and women's fertility outcomes in a Singaporean population-based preconception cohort

Cited by 20 publications

References 60 publications

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

Associations between per- and poly-fluoroalkyl substance (PFAS) exposure and immune responses among women in the California Teachers Study: a cross-sectional evaluation

How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature

The adverse role of endocrine disrupting chemicals in the reproductive system

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