Exposure to persistent organic pollutants in utero and related maternal characteristics on birth outcomes: A multivariate data analysis approach

Tan, Jia; Loganath, A.; Chong, Yap Seng; Obbard, Jeffrey Philip

doi:10.1016/j.chemosphere.2008.09.045

Cited by 104 publications

(66 citation statements)

References 48 publications

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“…Other than these reports, few data have been published on prenatal b-HCH exposure and thyroid hormone status, and they showed no association between b-HCH concentrations and thyroid hormone levels (Mazhitova et al, 1998). With regard to b-HCH umbilical cord levels, our results (median: 0.08 ng/ml or 34 ng/g) are lower than levels found by Torres-Arreola et al (2003) in Mexico (54.25 ng/g) and Ataniyazova et al (2001) in Uzbekistan (2060 ng/l), and higher (3.38 ng/g) than levels found in China (Tan et al, 2009).…”

Section: Discussioncontrasting

confidence: 51%

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

López-Espinosa

Vizcaino

Murcia

et al. 2009

J Expo Sci Environ Epidemiol

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It has been suggested that prenatal exposure to some organochlorine compounds (OCs) may adversely affect thyroid function and may, therefore, impair neurodevelopment. The main aim of this study was to examine the relationship of cord serum levels of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4 0 -DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4 0 -DDE), b-hexachlorocyclohexane (b-HCH), hexachlorobenzene (HCB), four individual polychlorobiphenyl (PCB) congeners (118, 138, 153, and 180), and their sum, with neonatal thyroid stimulating hormone (TSH) levels in blood samples in a mother-infant cohort in Valencia, Spain. This study included 453 infants born between 2004 and 2006. We measured OC concentrations in umbilical cord serum and TSH in blood of newborns shortly after birth. Associations between neonatal TSH levels and prenatal OC exposure adjusted for covariates were assessed using multivariate linear regression analyses. Neonatal TSH levels tended to be higher in newborns with b-HCH levels in umbilical cord above 90th percentile (104 ng/g lipid) than in those with levels below the median (34 ng/g lipid), with an adjusted increment in neonatal TSH levels of 21% (95% confidence interval ¼ À3, 51; P ¼ 0.09). No statistically significant association was found between the remaining OCs and TSH at birth. Prenatal exposure to b-HCH may affect neonatal thyroid hormone status and its function in neurological development.

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Section: Discussioncontrasting

confidence: 51%

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

López-Espinosa

Vizcaino

Murcia

et al. 2009

J Expo Sci Environ Epidemiol

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“…Vice versa, the positive p,p′-DDT-birth length relationship was found to be significant both in linear regression statistic approach and in neural network analysis. This result is in agreement with the results of a previous study (Tan et al, 2009) that showed also the association of p,p′-DDT levels in cord blood samples with both newborn head circumference and birth weight.…”

Section: Discussionsupporting

confidence: 83%

Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

Bergonzi

Palma

Specchia

et al. 2011

Science of The Total Environment

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“…Female umbilical blood from Singapore had higher β-HCH, but lower p,p'-DDT and p,p'-DDE than males (not significant) (Tan et al, 2009). For children aged 0-11 years from China, no differences were found between genders (Chen et al, 2010).…”

Section: Infant Gender and Levels Of Ddtmentioning

confidence: 81%

High levels of DDT in breast milk: Intake, risk, lactation duration, and involvement of gender

Bouwman

Kylin

Sereda

et al. 2012

Environmental Pollution

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We investigated presence and levels of DDT in 163 breast milk samples from four South African villages where, in three of them, malaria is controlled with DDT sprayed indoors. Mean ΣDDT levels in breast milk were 18, 11, and 9.5 mg/kg mf (milk fat) from the three DDT-sprayed villages, respectively, including the highest ΣDDT level ever reported for breast milk from South Africa (140 mg/kg mf). Understanding the causes for these differences would be informative for exposure reduction intervention. The Provisional Tolerable Daily Intake (PTDI) for DDT by infants, and the Maximum Residue Limit (MRL) were significantly exceeded. DDT had no effect on duration of lactation. There were indications (not significant) from DDT-sprayed villages that first-born female infants drink milk with more ΣDDT than first-born male infants, and vice versa for multipara male and female infants, suggesting gender involvement on levels of DDT in breast milk -requiring further investigation.

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Exposure to persistent organic pollutants in utero and related maternal characteristics on birth outcomes: A multivariate data analysis approach

Cited by 104 publications

References 48 publications

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

Persistent organochlorine compounds in fetal and maternal tissues: Evaluation of their potential influence on several indicators of fetal growth and health

High levels of DDT in breast milk: Intake, risk, lactation duration, and involvement of gender

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