Exposure to persistent organic pollutants as potential risk factors for developing diabetes

Wang, Chunxiang; Xu, Shunqing; Lv, Ziquan; Li, Yuanyuan; Wang, Youjie; Tian, Chen

doi:10.1007/s11426-010-0157-1

Cited by 17 publications

(8 citation statements)

References 133 publications

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“…Epidemiological studies have found associations between exposure to PCBs and effects on reproduction and (neuro)development, thyroid system, nervous system, immune system, cardiovascular system, growth, lipid metabolism, diabetes, and obesity (e.g., reviews by ATSDR, 2000;EFSA, 2005;Hatch et al, 2010;Korrick and Sagiv, 2009;Meeker and Hauser, 2010;Wang et al, 2010a). Many of the observed associations are still under scientific study and debate because they lack mechanistic support, are not expected at the measured exposure levels, or could not be confirmed in other studies.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Toxicity Profiling of Ultrapure Non–Dioxin-like Polychlorinated Biphenyl Congeners and Their Relative Toxic Contribution to PCB Mixtures in Humans

Hamers

Kamstra

Cenijn

et al. 2011

Toxicological Sciences

137

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The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Most PCBs in the environment, however, are non-dioxin-like (NDL) PCBs that cannot adopt a coplanar structure required for AhR activation. For NDL-PCBs, no generally accepted risk concept is available because their toxicity is insufficiently characterized. Here, we systematically determined in vitro toxicity profiles for 24 PCBs regarding 10 different mechanisms of action. Prior to testing, NDL-PCB standards were purified to remove traces of DL compounds. All NDL-PCBs antagonized androgen receptor activation and inhibited gap junctional intercellular communication (GJIC). Lower chlorinated NDL-PCBs were weak estrogen receptor (ER) agonists, whereas higher chlorinated NDL-PCBs were weak ER antagonists. Several NDL-PCBs inhibited estradiol-sulfotransferase activity and bound to transthyretin (TTR) but with much weaker potencies than reported for hydroxylated PCB metabolites. AhR-mediated expression of uridine-glucuronyl transferase isozyme UGT1A6 was induced by DL-PCBs only. Hierarchical cluster analysis of the toxicity profiles yielded three separate clusters of NDL-PCBs and a fourth cluster of reference DL-PCBs. Due to small differences in relative potency among congeners, the highly abundant indicator PCBs 28, 52, 101, 118, 138, 153, and 180 also contributed most to the antiandrogenic, (anti)estrogenic, antithyroidal, tumor-promoting, and neurotoxic potencies calculated for PCB mixtures reported in human samples, whereas the most potent AhR-activating DL-PCB-126 contributed at maximum 0.2% to any of these calculated potencies. PCB-168 is recommended as an additional indicator congener, given its relatively high abundance and antiandrogenic, TTR-binding, and GJIC-inhibiting potencies.

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Section: Discussionmentioning

confidence: 99%

In Vitro Toxicity Profiling of Ultrapure Non–Dioxin-like Polychlorinated Biphenyl Congeners and Their Relative Toxic Contribution to PCB Mixtures in Humans

Hamers

Kamstra

Cenijn

et al. 2011

Toxicological Sciences

137

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“…Reconocidos por el Programa de Medio Ambiente de las Naciones Unidas en el Convenio de 1995 de Estocolmo, en su mayoría son denominados compuestos orgánicos persistentes (COPs) ó "POPs" (Persistent Organic Pollutants). En este grupo se destacan las dioxinas, los furanos, los bifenilos policlorados (PCB) y algunos pesticidas, los cuales por sus efectos adversos fueron prohibidos en 1970 (3,78,79). Estos compuestos poseen características tales como lipofi licidad, persistencia, baja degradación y toxicidad (80), y están asociados a teratogenecidad, disrupción endocrina, bioacumulación en el tejido adiposo, resistencia a la insulina y diabetes (81 …”

Section: Vía Mitogénica O Vía De La Proteína Cinasa Activadora De La unclassified

“…Están presentes en transformadores, condensadores eléctricos, fl uidos hidráulicos, aditivos de aceite para pinturas, calafateo de ventanas, techo o pavimento (3,78). Para los PCBs existen 209 congéneres posibles, los cuales han sido clasifi cados como tipo "dioxinas" y tipo "no dioxinas" (79). Estudios en animales, han mostrado que estas moléculas generan cambios bioquímicos en las células β pancreáticas (35,36), así como disminución de la sensibilidad a la insulina y alteraciones en la homeostasis de la glucosa, el metabolismo de lípidos, y en la función tiroidea (99).…”

Section: Los Policlorobifenilos (Pcb) O Bifenilos Policloradosunclassified

Aspectos epidemiológicos de la diabetes mellitus y su relación con los contaminantes ambientales

Arroyo-Salgado

Olívero-Verbel

2014

Rev. chil. nutr.

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“…In fetal bones, there was a reduction in circumference and marrow cavity area in the female fetuses compared with female control fetuses. Wang, et al (2010) studied whether or not exposure to persistent organic pollutants was related to developing diabetes; results were inconclusive and further study was recommended.…”

Section: Toxicitymentioning

confidence: 99%

Emerging Pollutants

Bell¹,

Wells²,

Traexler³

et al. 2011

Water Environment Research

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Exposure to persistent organic pollutants as potential risk factors for developing diabetes

Cited by 17 publications

References 133 publications

In Vitro Toxicity Profiling of Ultrapure Non–Dioxin-like Polychlorinated Biphenyl Congeners and Their Relative Toxic Contribution to PCB Mixtures in Humans

In Vitro Toxicity Profiling of Ultrapure Non–Dioxin-like Polychlorinated Biphenyl Congeners and Their Relative Toxic Contribution to PCB Mixtures in Humans

Aspectos epidemiológicos de la diabetes mellitus y su relación con los contaminantes ambientales

Emerging Pollutants

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