Exposure to pesticide as a risk factor for depression: A population-based longitudinal study in Korea

Koh, Sang Baek; Kim, Tae Hui; Min, Sung Kil; Lee, Kyungsuk; Kang, Dae Ryong; Choi, Jung Ran

doi:10.1016/j.neuro.2017.07.005

Cited by 51 publications

(45 citation statements)

References 30 publications

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“…Results showed that dieldrin was positively associated with the depression score in patients with PD. A study conducted in Korea demonstrated exposure to pesticides was a risk factor for depression [29]. A longitudinal study also found a link between exposure to dieldrin and depression [30].…”

Section: Discussionmentioning

confidence: 99%

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Xu¹,

Yang²,

Qian³

et al. 2020

Preprint

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Background: There is evidence that genetic and environmental factors contribute to the onset and progression of Parkinson’s disease (PD). Pesticides are a class of environmental toxins that are linked to increased risk of PD. However, few studies have investigated the interaction between specific pesticides and genetic variants related to PD in the Chinese population.Methods: In this cross-sectional study, 19 serum levels of pesticides were measured. In addition, we also analyzed the interaction between specific pesticides and candidate genetic variants for PD. Finally, we investigated the mechanistic basis for the association between pesticides and increased risk of PD.Results: Serum levels of organochlorine pesticides including α-hexachlorocyclohexane (α-HCH), β-HCH, γ-HCH, δ-HCH, propanil, heptachlor, dieldrin, hexachlorobenzene, p,p’-dichlorodiphenyltrichloroethane (p,p’-DDE) and o,p’-dichloro-diphenyl-trichloroethane (o,p’-DDT) were higher in PD patients than in controls. α-HCH and propanil levels were associated with increased PD risk. Serum levels of dieldrin were associated with Hamilton Depression Scale and Montreal Cognitive Assessment scores in PD patients. The interaction between rs11931074 in α-synuclein (SNCA) and α-HCH or β-HCH, respectively, as well as rs16940758 in the microtubule-associated protein tau (MAPT) gene and δ-HCH were related to increased risk of PD. In addition, α-HCH and propanil enhanced the production of reactive oxygen species and decreased of mitochondrial membrane potential. Propanil but not α-HCH induced the aggregation of α-synuclein.Conclusions: Elevated serum levels of α-HCH and propanil are associated with increased risk of PD. Serum levels of dieldrin were associated with depression and cognitive function in PD patients. The interaction between genetic variants and pesticides also increased the risk of PD. Effects of genetic variants and pesticides on the risk of PD should be studied in more detail with a larger sample size to further understand the mechanisms involved.

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Section: Discussionmentioning

confidence: 99%

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Xu¹,

Yang²,

Qian³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This finding is important because psychiatric follow up enables health workers to diagnose underlying causes of self-harm such as depression and other mental disorders [29,31]. Literature shows that self-harm patients account for the highest percentage of morbidity and mortality due to pesticide poisoning [32,33]. This implies that efforts should be made to include psychiatric units in all health facilities handling pesticide poisoning patients.…”

Section: Discussionmentioning

confidence: 99%

Doctors experiences on the quality of care for pesticide poisoning patients in hospitals in Kampala, Uganda: a qualitative exploration using donabedian’s model

Ssemugabo

Nalinya

Halage

et al. 2020

BMC Health Serv Res

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Background: Pesticides are responsible for a significant percentage of deaths globally with majority occurring in sub-Saharan Africa. Deaths due to pesticide poisoning can be reduced if poisoning cases are managed optimally. However, the quality of care given to pesticide poisoning patients is still insufficient especially in sub-Saharan Africa. This study was aimed at exploring doctors' experiences on quality of care for pesticide poisoning cases in hospitals in Kampala, Uganda. Methods: Fifteen (15) in-depth interviews were conducted with doctors who were directly involved in management of pesticide poisoning patients in the accident and emergency, Medicine, Pediatrics and Intensive Care Unit wards in 5 hospitals in Kampala, Uganda. All interviews were transcribed and subjected to directed content analysis with the guidance of the Donabedian model of quality of care which emphasizes structure, process and outcome measures as pertinent to ensuring quality of care. Results: Doctors reported structural, process and outcome facets that support diagnosis and treatment of pesticide poisoning cases that improved the quality of care they provided. Among the structures includes hospital units such as Intensive Care Unit (ICU), pediatrics and internal medicine; equipment and clinical guidelines such as airway, breathing and consciousness (ABC) protocol; and doctors' knowledge and experiences. Doctors relied on history, and signs and symptoms to establish the cause and severity of pesticide poisoning. However, some patients and caretakers provided inaccurate pesticide poisoning history. Due to its availability in hospitals, doctors largely relied on atropine to manage pesticide poisoning cases whether or not relevant to treat the actual pesticide active ingredient responsible for the poisoning. Although majority of the cases treated recovered, those due to suicide were further referred to the hospital psychiatrist. Sharing experiences of managing pesticide poisoning patients among health workers and engaging in sensitization outreaches against pesticide poisoning were reported as potential activities to improve quality of care for pesticide poisoning patients. Conclusion: Doctors reflected on the structure, process and outcome measures of quality of care given to pesticide poisoning patients. The implications of hospital structures and clinical process to the quality of the outcomes of care demonstrates their importance in improving management of pesticide poisoning cases in hospitals in Kampala, Uganda.

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“…Experimental studies have shown that pesticides act as neurotoxic and endocrine-disrupting toxins. 20 A study in China found that a 10% increase in pesticide use in rice increased a key medical disability index by 1% among rural residents 65 and older, resulting in $2.13 and $0.64 million dollars in medical and family care costs, respectively. 21 …”

Section: Discussionmentioning

confidence: 99%

Assessment of Pesticide-Related Pollution and Occupational Health of Vegetable Farmers in Benguet Province, Philippines

2017

Journal of Health and Pollution

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Background.Agriculture accounts for 20% of the national income in the Philippines. In order to boost agricultural activity and prevent crop damage, farmers rely on pesticides for vector control and management.Objectives.The present study assessed the pesticide exposure and occupational health of agricultural farmers in the Philippines. The study site is one of the largest vegetable-producing provinces in the Philippines.Methods.This study employed both a survey questionnaire and physical health assessment, including a mental state examination. Pesticide exposure was estimated based on the duration of pesticide use, as well as the amount per spray application. The data results were segregated by gender, as women are also heavily engaged in agriculture in this part of the Philippines.Results.The results showed that pesticide exposure usually occurred during agricultural activities such as spray applications in the field (63.7%), mixing (38.4%), loading (34.1%) and field re-entry (9.7%). The most frequently used pesticides were Tamaron, Selecron, and Dithane. The mean duration of pesticide exposure was 14.23 years for males and 15.4 years for females. The longest used pesticide among males was Sumicidine (16.2 years), and Tamaron for females (18 years). In terms of amount used, the average was 147 ml per spray application for males and 65.5 ml for females. Exposure to pesticides was expressed in number of years and amount used per spray application, and the average exposure of males was 2,024.43 ml/years and 993.55 ml/years for females. Among farmers, 49% complained of being sick due to their work. Of those who became ill, a large percentage (69.8%) did not receive any medical attention. The most prevalent health symptoms were muscle pains (63.3%), muscle weakness (55%), and easy fatigability (52.4%). For the mini-mental state examination, abnormalities were found in 5.4% of males and 13.3% of females. The use of insecticides was associated with weakness, easy fatigability and weight loss.Discussion.The present study demonstrated frequent and significant duration of pesticide use among farmers in Benguet province, Philippines.Conclusions.Pesticide exposure was considerable among the farmers in the present study. The occupational health conditions reported by the study subjects can be linked to their pesticide use. Although this study assessed risk factors associated with general health symptoms, further investigation is needed to determine specific pesticide exposure-health correlations.Participant Consent.ObtainedEthics Approval.The study was approved by the Research Ethics Board of the University of the Philippines, Manila, which is recognized and accredited by the Forum for Ethical Review Committees in Asia and the Western Pacific (FERCAP).

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Exposure to pesticide as a risk factor for depression: A population-based longitudinal study in Korea

Cited by 51 publications

References 30 publications

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

Doctors experiences on the quality of care for pesticide poisoning patients in hospitals in Kampala, Uganda: a qualitative exploration using donabedian’s model

Assessment of Pesticide-Related Pollution and Occupational Health of Vegetable Farmers in Benguet Province, Philippines

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