Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: The food chain as main source of contamination

Donato, Francesco; Magoni, Michele; Bergonzi, Roberto; Scarcella, Carmelo; Indelicato, A.; Carasi, Sergio; Apostoli, Pietro

doi:10.1016/j.chemosphere.2005.11.057

Cited by 76 publications

(47 citation statements)

References 16 publications

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“…The causal association between POPs and cancer has however been questioned (Golden and Kimbrough 2009). In addition, some studies show that people living in industrial contaminated areas have higher concentrations of POPs in plasma compared to control populations (Hovander et al 2006) and that people consuming locally produced food in contaminated areas have higher concentrations of POPs compared to people consuming locally produced food in non-contaminated areas (Donato et al 2006;Langer et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer

Ljunggren

Helmfrid

Salihović

et al. 2014

Environment International

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Graphical AbstractLeft panels: Higher concentrations of PCBs and OCPs in HDL from subjects with CVD and cancer than healthy controls. Upper right panel: Enrichment of highly chlorinated PCB congeners in HDL. Lower right panel: Less activity of the HDL anti-oxidant enzyme PON1 in subjects with high PCB concentrations than in subjects with low PCB concentrations. HighlightsHigher POP concentrations in subjects with CVD or cancer compared to healthy controls AbstractPersistent organic pollutants (POPs) are lipophilic environmental toxins that have been associated with cardiovascular disease (CVD) and cancer. The aim of this study was to investigate the concentrations of POPs in human high and low/very low-density lipoproteins (HDL and LDL/VLDL) and the possible association with CVD and cancer occurrence in individuals living in a contaminated area. Lipoproteins from 28 individuals (7 healthy controls, 8 subjects with cancer, 13 subjects with CVD) were isolated and the fraction-specific concentration of 20 different POPs was analyzed by high resolution gas chromatography/high resolution mass spectrometry. The activity of Paraoxonase 1 (PON1), an anti-oxidant in HDL, was determined in plasma of these 28 subjects and additional 50 subjects from the same area excluding diseases other than cancer or CVD. Fourteen polychlorinated biphenyls (PCBs) and three organochlorine pesticides were detected, and especially highly chlorinated PCBs were enriched in lipoproteins. Significantly higher concentrations of POPs were found among individuals with CVD or cancer compared to controls. Principal component analyses showed that POP concentrations in HDL were more associated with CVD, while POP concentrations in LDL/VLDL were more associated with cancer. PON1 activity was negatively correlated to sumPCB and a co-variation between decreased arylesterase-activity, increased PCB concentrations and CVD was found. This study shows that POPs are present in lipoproteins and were more abundant in individuals with CVD or cancer compared to healthy controls. The results also indicate that PCB exposure is accompanied by reduced PON1 activity that could impair the HDL function to protect against oxidation.

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Section: Introductionmentioning

confidence: 99%

Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer

Ljunggren

Helmfrid

Salihović

et al. 2014

Environment International

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“…There might be some differences in the prevalence and/or amount of consumption of locally grown products (home grown vegetables, but also home produced eggs). The influence of the consumption of locally produced foods on serum levels of lipophilic contaminants, was also reported in other studies (Donato et al, 2006). However, the questionnaire did not provide enough detailed information to study this relationship adequately.…”

Section: Factors Influencing Pcdd/f Levelsmentioning

confidence: 65%

The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

Bilau

Henauw

Schroijen

et al. 2009

Environment International

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Dioxin-like activity was measured in the serum of 1425 Flemish men and women via the CALUX assay. The adults, aged between 50 and 65 years, participated in a large biomonitoring program, executed by the Flemish Center of Expertise for Environment and Health between 2002 and 2006. Within the context of this biomonitoring program also dietary intake of dioxin-like contaminants was assessed through a food frequency questionnaire. The relation between the estimated dietary intake and the dioxin-like activity in serum was evaluated using multivariate analyses: a logistic model was performed on the total population, while a linear regression analysis was done on the subsample with quantifiable dioxin activity levels in serum. Region, gender, age, BMI, smoking status, as well as dietary habits were entered in the model, with dioxin level as an outcome estimate. Both the logistic and linear model confirmed the contribution of dietary intake to the dioxin activity measured in serum. Also BMI and region were found to be associated with dioxin activity levels.

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“…Em estudo recente, realizado por MOHR et al (2011), que utilizaram sangue de cordão umbilical, foi encontrado um valor médio de 5,64ng mL -1 para o ∑PCBs 28, 52, 138, 153 e 180, demonstrando que a contaminação existente nos alimentos é transmitida para os seres humanos através do consumo de alimentos contaminados. Este dado concorda com os relatados no estudo realizado na Itália, por DONATO et al (2006), que associaram a presença de altos níveis de PCBs em soro sanguíneo de moradores residentes perto de uma indústria química, com o consumo de alimentos produzidos em áreas contaminadas. Estes dados demonstram a importância do monitoramento da contaminação alimentar por resíduos químicos, especialmente por PCBs.…”

Section: Resultsunclassified

Bifenilos policlorados em arroz e feijão do estado do Rio Grande do Sul

et al. 2015

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Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: The food chain as main source of contamination

Cited by 76 publications

References 16 publications

Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer

Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer

The relation between the estimated dietary intake of PCDD/Fs and levels in blood in a Flemish population (50–65 years)

Bifenilos policlorados em arroz e feijão do estado do Rio Grande do Sul

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