Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy – relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)

Nilsson, Robert; Antić, Ruza; Berni, Andrea; Dallner, Gustav; Dettbarn, G.; Gromadzińska, Jolanta; Joksić, Gordana; Lundin, Cecilia; Palitti, F.; Prochazka, Gabriela; Rydzyński, K; Segerbäck, Dan; Souček, Pavel; Tekle, Michael; Seidel, Albrecht

doi:10.3109/1354750x.2012.762807

Cited by 15 publications

(5 citation statements)

References 37 publications

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“…Polycyclic aromatic hydrocarbons (PAHs) are common environmental carcinogens that induce tumorigenesis when they are activated by CYPs (98). They accumulate in breast tissues (99), and are metabolized and activated by CYP1A1 to produce electrophilic epoxy compounds with strong carcinogenic activity, which change the base pairing of DNA, cause codon changes, introduce mutations and eventually lead to cancer (100). Therefore, the activity of CYP1A1 isoenzyme in breast tissues is the key to determine the carcinogenicity of PAHs.…”

Section: Effect Of Cyps On Carcinogen Metabolismmentioning

confidence: 99%

Cytochrome P450: Implications for human breast cancer (Review)

Luo

Yan

et al. 2021

Oncol Lett

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The treatment options for breast cancer include endocrine therapy, targeted therapy and chemotherapy. However, some patients with triple-negative breast cancer cannot benefit from these methods. Therefore, novel therapeutic targets should be developed. The cytochrome P450 enzyme (CYP) is a crucial metabolic oxidase, which is involved in the metabolism of endogenous and exogenous substances in the human body. Some products undergoing the metabolic pathway of the CYP enzyme, such as hydroxylated polychlorinated biphenyls and 4-chlorobiphenyl, are toxic to humans and are considered to be potential carcinogens. As a class of multi-gene superfamily enzymes, the subtypes of CYPs are selectively expressed in breast cancer tissues, especially in the basal-like type. In addition, CYPs are essential for the activation or inactivation of anticancer drugs. The association between CYP expression and cancer risk, tumorigenesis, progression, metastasis and prognosis has been widely reported in basic and clinical studies. The present review describes the current findings regarding the importance of exploring metabolic pathways of CYPs and gene polymorphisms for the development of vital therapeutic targets for breast cancer.

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Section: Effect Of Cyps On Carcinogen Metabolismmentioning

confidence: 99%

Cytochrome P450: Implications for human breast cancer (Review)

Luo

Yan

et al. 2021

Oncol Lett

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“…The overall trend was that higher adduct levels were observed in smokers compared to nonsmokers. Since 2012, continuous efforts have been made to measure bulky DNA adducts in human samples including lung and leukocytes (Table 1) [39,40,41,42,43,44,45,46,47,48,49,50,51,52]. Smoking is a contributor to adduct formation in these studies.…”

Section: Smoking-related Dna Adducts In Humansmentioning

confidence: 99%

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke

Stepanov

Hecht

2019

Toxics

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DNA adducts are believed to play a central role in the induction of cancer in cigarette smokers and are proposed as being potential biomarkers of cancer risk. We have summarized research conducted since 2012 on DNA adduct formation in smokers. A variety of DNA adducts derived from various classes of carcinogens, including aromatic amines, polycyclic aromatic hydrocarbons, tobacco-specific nitrosamines, alkylating agents, aldehydes, volatile carcinogens, as well as oxidative damage have been reported. The results are discussed with particular attention to the analytical methods used in those studies. Mass spectrometry-based methods that have higher selectivity and specificity compared to 32P-postlabeling or immunochemical approaches are preferred. Multiple DNA adducts specific to tobacco constituents have also been characterized for the first time in vitro or detected in vivo since 2012, and descriptions of those adducts are included. We also discuss common issues related to measuring DNA adducts in humans, including the development and validation of analytical methods and prevention of artifact formation.

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“…CYPs activate polycyclic aromatic hydrocarbons (PAHs), which are common environmental carcinogens, to induce tumorigenesis [180]. PAHs will accumulate in breast tissues [181] and cause mutation after they are metabolized and activated by CYP1A1 [182]. Therefore, it is important to know the significance of CYPs in contributing to the initiation of BC.…”

Section: Modulation Of Carcinogen Metabolismmentioning

confidence: 99%

Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer

Lau

Kwan

2022

Marine Drugs

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Breast cancer (BC) is one of the most common cancers diagnosed and the leading cause of cancer-related death in women. Although there are first-line treatments for BC, drug resistances and adverse events have been reported. Given the incidence of BC keeps increasing, seeking novel therapeutics is urgently needed. Fucoxanthin (Fx) is a dietary carotenoid commonly found in seaweeds and diatoms. Both in vitro and in vivo studies show that Fx and its deacetylated metabolite fucoxanthinol (Fxol) inhibit and prevent BC growth. The NF-κB signaling pathway is considered the major pathway contributing to the anti-proliferation, anti-angiogenesis and pro-apoptotic effects of Fx and Fxol. Other signaling molecules such as MAPK, MMP2/9, CYP and ROS are also involved in the anti-cancer effects by regulating the tumor microenvironment, cancer metastasis, carcinogen metabolism and oxidation. Besides, Fx also possesses anti-obesity effects by regulating UCP1 levels and lipid metabolism, which may help to reduce BC risk. More importantly, mounting evidence demonstrates that Fx overcomes drug resistance. This review aims to give an updated summary of the anti-cancer effects of Fx and summarize the underlying mechanisms of action, which will provide novel strategies for the development of Fx as an anti-cancer therapeutic agent.

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Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy – relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)

Cited by 15 publications

References 37 publications

Cytochrome P450: Implications for human breast cancer (Review)

Cytochrome P450: Implications for human breast cancer (Review)

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke

Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer

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