Exposure to polystyrene nanoplastics and PCB77 induced oxidative stress, histopathological damage and intestinal microbiota disruption in white hard clam Meretrix lyrata

Kong, Chunmiao; Pan, Ting; Chen, Xikun; Junaid, Muhammad; Liao, Hongping; Gao, Dandan; Wang, Qiuping; Liu, Wanjing; Wang, Xu; Wang, Jun

doi:10.1016/j.scitotenv.2023.167125

Cited by 7 publications

(2 citation statements)

References 70 publications

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“… 18 – 20 NPs can influence chemicals through various mechanisms, including alterations in chemical intake, 21 perturbation of tissue distribution, 22 bioaccumulation, biodegradation, 23 and increased susceptibility of organisms to harmful substances. 24 Endocrine-disrupting compounds (EDCs) represent a prominent class of environmental pollutants, and their toxicities may be modulated by NPs through the aforementioned intrinsic pathways. 25 Although a growing body of study has associated NPs with neurotoxicity, 26 lung toxicity, 27 hepatotoxicity, 28 cardiovascular toxicity, 29 , 30 and testicular toxicity, 31 their effects on estrogenicity when combined with EDCs remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Ye,

Li,

Xian

et al. 2024

Environ Health Perspect

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Background: Micro- and nanoplastics (MNPs) and homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, the interaction between MNPs and HMS and its impact on HMS-induced EDEs remain unclear. Objectives: This study aimed to investigate the influence of MNPs on HMS-induced estrogenic effects and elucidate the underlying mechanisms in vitro and in vivo . Methods: We assessed the impact of polystyrene nanospheres (PNSs; , ) on HMS-induced MCF-7 cell proliferation (HMS: , equivalent to ) using the E-SCREEN assay and explored potential mechanisms through transcriptomics. Adult zebrafish were exposed to HMS ( ) with or without PNSs ( , ) for 21 d. EDEs were evaluated through gonadal histopathology, fertility tests, steroid hormone synthesis, and gene expression changes in the hypothalamus–pituitary–gonad–liver (HPGL) axis. Results: Coexposure of HMS and PNSs resulted in higher expression of estrogen receptor ( ESR1 ) and the mRNAs of target genes ( pS2 , AREG , and PGR ), a greater estrogen-responsive element transactivation activity, and synergistic stimulation on MCF-7 cell proliferation. Knockdown of serum and glucocorticoid-regulated kinase 1 (SGK1) rescued the MCF-7 cell proliferation induced by PNSs alone or in combination with HMS. In zebrafish, coexposure showed higher expression of SGK1 and promoted ovary development but inhibited spermatogenesis. In addition, coexposure led to lower egg hatchability, higher embryonic mortality, and greater larval malformation. Coexposure also modulated steroid hormone synthesis genes ( cyp17a2 , hsd17 1 , esr2b , vtg1 , and vtg2 ), and resulted in higher ( ) release in females. Conversely, males showed lower testosterone, , and gene expressions of cyp11a1 , cyp11a2 , cyp17a1 , cyp17a2 , and hsd17 1 . Discussion: PNS exposure exacerbated HMS-induced estrogenic effects via SGK1 up-regulation in MCF-7 cells and disrupting the HPGL axis in zebrafish, with gender-specific patterns. This offers new mechanistic insights and health implications of MNP and contaminant coexposure. https://doi.org/10.1289/EHP13696

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Section: Introductionmentioning

confidence: 99%

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Ye,

Li,

Xian

et al. 2024

Environ Health Perspect

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“…Aquatic organisms inadvertently ingest these plastics, leading to their accumulation within their bodies [6][7][8]. This perpetual accumulation triggers adverse effects at the cellular, subcellular, and tissue levels, encompassing tissue damage [9,10], oxidative stress [11][12][13][14][15], induced lipid accumulation [16][17][18][19], metabolic disorders [20], digestive tract obstruction or injury [21], and disruption in growth and reproduction [17,22]. NPs (<1000 nm), being several orders of magnitude smaller than MPs, are more prone to absorption and concentration within aquatic organisms [23,24].…”

Section: Introductionmentioning

confidence: 99%

Combined Toxicity of Polystyrene Nanoplastics and Pyriproxyfen to Daphnia magna

Jia,

Zhang,

Gao

et al. 2024

Sustainability

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In recent years, the adverse effects of nanoplastics (NPs) and pyriproxyfen on aquatic environments have attracted widespread attention. However, research on their combined exposure to aquatic organisms could be more extensive. This work evaluated the acute and chronic toxic effects of polystyrene NPs (PS-NPs) and pyriproxyfen on Daphnia magna (D. magna) under their combined exposure conditions. The addition of PS-NPs within 24 h reduced the acute toxicity of pyriproxyfen to D. magna, resulting in an increase in the 24-h EC50 values of pyriproxyfen on D. magna from 0.24 mg/L to 0.35, 0.51, and 1.26 mg/L, respectively when 1, 5, and 10 mg/L of PS-NPs were added. Compared with PS-NPs, pyriproxyfen significantly disturbed the growth and reproduction of D. magna in the chronic toxicity test at 21 days. The adverse effects caused by pyriproxyfen were alleviated when PS-NPs and pyriproxyfen were co-exposed. In addition, it was observed that the addition of pyriproxyfen resulted in less PS-NPs uptake by D. magna using a time-gated imaging technique. These findings provide new insight into the combined toxic effects of NPs and pyriproxyfen on the reproduction and growth of D. magna, and it is important to understand the effects of complex pollutants on aquatic systems. Moreover, it has provided an important scientific basis for environmental protection and sustainable development.

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Exposure to polystyrene microplastics and perfluorooctane sulfonate disrupt the homeostasis of intact planarians and the growth of regenerating planarians

Huang,

Zhang,

Sun

et al. 2024

Science of The Total Environment

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Exposure to polystyrene nanoplastics and PCB77 induced oxidative stress, histopathological damage and intestinal microbiota disruption in white hard clam Meretrix lyrata

Cited by 7 publications

References 70 publications

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Combined Toxicity of Polystyrene Nanoplastics and Pyriproxyfen to Daphnia magna

Exposure to polystyrene microplastics and perfluorooctane sulfonate disrupt the homeostasis of intact planarians and the growth of regenerating planarians

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