Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK/STAT and MAPK pathways

Fu, Huiyang; Ge, Yao; Liu, Xiyuan; Deng, Siwei; Li, Jun; Tan, Peng; Yang, Ying; Wu, Zhenlong

doi:10.1016/j.scitotenv.2024.171711

Science of The Total Environment

2024

DOI: 10.1016/j.scitotenv.2024.171711

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Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK/STAT and MAPK pathways

Huiyang Fu,

Yao Ge,

Xiyuan Liu

et al.

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Cited by 5 publications

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Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Ren,

Gao,

et al. 2024

Molecular Nutrition Food Res

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ScopePrevious study has demonstrated the chemical structure of chondroitin sulfate (CHS) from Halaelurus burgeri skin and its effects on insulin resistance. However, the precise impact of this phenomenon on endoplasmic reticulum (ER) stress and inflammation, which contribute to insulin resistance, remains unclear. This study is to investigate the impact of CHS on ER stress, inflammatory response and signaling, and gut microbiota in high‐fat diet (HFD)‐fed mice.Methods and resultsHFD‐fed C57BL/6J mice receive dietary gavage intervention of CHS for 18 weeks. Blood, liver tissue, and feces are harvested for further investigation. Results show that CHS inhibits ER stress, accompanied by lowered blood glucose, nitric oxide (NO), reactive oxygen (ROS), and free fatty acids (FFA) levels, and increases hepatic glycogen accumulation. Moreover, hepatic inflammation is improved by CHS treatment via inactivation of Toll‐like receptor 4 (TLR4) signaling and its downstream c‐jun N‐terminal kinase (JNK) and nuclear factor kappa B (NFκB) pathways. Additionally, CHS regulates gut microbiota, particularly the decline in the Firmicutes to Bacteroidetes ratio. CHS also lowers fecal lipopolysaccharide and elevates several fecal short chain fatty acids.ConclusionThese findings suggest that CHS from H. burgeri skin may be an alternative functional food supplement for anti‐ER stress, anti‐inflammtion, and regulation of gut microbiota.

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Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Ren,

Gao,

et al. 2024

Molecular Nutrition Food Res

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show abstract

Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage

Du,

Zeng,

Wang

et al. 2025

Ecotoxicology and Environmental Safety

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p38 MAPK determines the sensitivity of the aquatic keystone species Moina macrocopa to toxic Microcystis: Insights into potential biomarker applications

Lyu,

Fan,

Zhou

et al. 2025

Environmental Pollution

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Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK/STAT and MAPK pathways

Cited by 5 publications

References 87 publications

Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota

Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage

p38 MAPK determines the sensitivity of the aquatic keystone species Moina macrocopa to toxic Microcystis: Insights into potential biomarker applications

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