Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats

Chartoff, Elena H.; Potter, David N.; Damez-Werno, Diane; Cohen, Bruce M.; Carlezon, William A.

doi:10.1038/sj.npp.1301659

Cited by 72 publications

(96 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the ''temporal order'' is switched and KORs are stimulated with agonists prior to psychostimulant administration, the psychostimulant-induced behavioral, neurochemical, and molecular effects are diminished. Pretreatment with synthetic or naturally occurring KOR agonists (15-20 min prior) decreases the behavioral-and locomotor-activating effects of acute and sensitizing-regimens of systemic cocaine [156,[315][316][317][318] and amphetamine [163,300,319]. Acute KOR agonist administration 15-20 min prior to conditioning decreases cocaine-induced CPP in rats [320] and mice [318,321,322], suggesting that KOR agonists decrease the conditioned rewarding effects of psychostimulants.…”

Section: Anti-psychostimulant Effects Of Kor Agonistsmentioning

confidence: 99%

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda

Shippenberg

Henriksson

2011

Cell. Mol. Life Sci.

148

144

View full text Add to dashboard Cite

The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function. We overview the pharmacology, signaling, post-translational, post-transcriptional, transcriptional, epigenetic and cis regulation of the dynorphin/κ-opioid receptor system, and critically review functional neuroanatomical, neurochemical, and pharmacological evidence, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia. We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development.

show abstract

Section: Anti-psychostimulant Effects Of Kor Agonistsmentioning

confidence: 99%

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda

Shippenberg

Henriksson

2011

Cell. Mol. Life Sci.

148

144

View full text Add to dashboard Cite

show abstract

“…These effects most likely result from the inhibition of limbic DA release after acute administration of κ-agonists [34,88,92,93] . However, there is paradoxical evidence that continuous or prior exposure to κ-agonists can potentiate the rewarding effects of cocaine under stress conditions and stress-induced reinstatement [36,94,95] . This evidence suggests that selective antagonists of KOR may represent useful and powerful therapeutic treatments for protecting individuals from relapse to drug abuse.…”

Section: Potential Therapeutic Applications Of κ-Opioid Agonists In Pmentioning

confidence: 99%

“…The Dyn/KOR system can mediate antinociception and drug reward through presynaptic and postsynaptic modulation of the levels of several neurotransmitters such as dopamine (DA), γ-Aminobutyric acid (GABA) and glutamate [19,34] . It has been well established that the Dyn/KOR system exerts an inhibitory effect on brain reward function by suppressing DA release from the mesolimbic reward pathway and the nigrostriatal pathway [4,[35][36][37][38] . These brain regions are intimately associated with the development of drug dependence.…”

Section: Introductionmentioning

confidence: 99%

The role of κ-opioid receptor activation in mediating antinociception and addiction

et al. 2010

View full text Add to dashboard Cite

The κ-opioid receptor (KOR), a member of the opioid receptor family, is widely expressed in the central nervous system and peripheral tissues. Substantial evidence has shown that activation of KOR by agonists and endogenous opioid peptides in vivo may produce a strong analgesic effect that is free from the abuse potential and the adverse side effects of µ-opioid receptor (MOR) agonists, such as morphine. In addition, activation of the KOR has also been shown to exert an inverse effect on morphine-induced adverse actions, such as tolerance, reward, and impairment of learning and memory. Therefore, the KOR has received much attention in the effort to develop alternative analgesics to MOR agonists and agents for the treatment of drug addiction. However, KOR agonists also produce several severe undesirable side effects such as dysphoria, water diuresis, salivation, emesis, and sedation in nonhuman primates, which may limit the clinical utility of KOR agonists for pain and drug abuse treatment. This article will review the role of KOR activation in mediating antinociception and addiction. The possible therapeutic application of κ-agonists in the treatment of pain and drug addiction is also discussed.

show abstract

“…; 30 min), ICI204448 (10 -32 mg/kg; 30 min), ketoprofen (1 mg/kg; 30 min), cocaine (1-10 mg/kg; 10 min), and flupenthixol (0.1-1.0 mg/kg; 60 min). Doses and pretreatment times were based on preliminary studies and previous studies in the literature (Corbett, 1990;Barber et al, 1994;McCurdy et al, 2006;Chartoff et al, 2008;Spofford et al, 2009). Three sequential test components were conducted immediately after administration of lactic acid or its vehicle.…”

Section: Assay Of Intracranial Self-stimulationmentioning

confidence: 99%

Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats

Negus¹,

O'Connell²,

Morrissey³

et al. 2011

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Opioid receptor agonists that do not readily cross the bloodbrain barrier are peripherally restricted and distribute poorly to the central nervous system after systemic administration. Peripherally restricted agonists have promise as candidate analgesics, because they may produce antinociception mediated by peripheral receptors more potently than they produce undesirable sedative and psychotomimetic effects mediated by central receptors. The present study used assays of painrelated stimulation and depression of behavior in rats to compare effects of 1) two peripherally restricted agonists [the, 2) a centrally penetrating agonist (salvinorin A), and 3) several reference drugs, including a nonsteroidal antiinflammatory drug (NSAID; ketoprofen). Intraperitoneal injection of dilute lactic acid served as a noxious stimulus to stimulate a stretching response and depress intracranial self-stimulation (ICSS) maintained by the delivery of electrical brain stimulation to the medial forebrain bundle. Acid-stimulated stretching was blocked by ketoprofen, the peripherally restricted agonists, and salvinorin A. However, acid-induced depression of ICSS was blocked only by ketoprofen. The peripherally restricted agonists had little effect, and salvinorin A exacerbated acidinduced depression of ICSS. These results suggest that peripherally restricted agonists may be safer than centrally penetrating agonists but less efficacious than NSAIDS or opioid receptor agonists to block pain-related depression of behavior; however, the peripheral selectivity of ffir and ICI204448 is limited, and future studies with agonists capable of greater peripheral selectivity are warranted.

show abstract

Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats

Cited by 72 publications

References 64 publications

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

The role of κ-opioid receptor activation in mediating antinociception and addiction

Effects of Peripherally Restricted κ Opioid Receptor Agonists on Pain-Related Stimulation and Depression of Behavior in Rats

Contact Info

Product

Resources

About