2020
DOI: 10.1016/j.ecoenv.2020.111051
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Exposure to waterborne cadmium induce oxidative stress, autophagy and mitochondrial dysfunction in the liver of Procypris merus

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Cited by 54 publications
(11 citation statements)
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“…Studies have demonstrated Cd can induce oxidative damage in different tissues by enhancing membrane lipid peroxidation and changing cellular antioxidant system (Amamou et al 2015, Dai et al 2020, Ren et al 2019. In this study, the activities of GSH were signi cantly increased in the liver of Cd-treated mice.…”
Section: Discussionsupporting
confidence: 46%
“…Studies have demonstrated Cd can induce oxidative damage in different tissues by enhancing membrane lipid peroxidation and changing cellular antioxidant system (Amamou et al 2015, Dai et al 2020, Ren et al 2019. In this study, the activities of GSH were signi cantly increased in the liver of Cd-treated mice.…”
Section: Discussionsupporting
confidence: 46%
“…Heat shock proteins have demonstrated the capacity of inducing the long-lasting protective immune responses and HSPs have been considered as proinflammatory damage-associated molecular response especially HSP60 and HSP70 [ 25 , 26 ]. In the present investigation, the adaptive immune response of freshwater fish C. idella was studied by investigating the differential expression levels changes of HSP and MT genes exposed to cadmium toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…Usually, Cd ions in the water environment first enter the fish body through gill respiration, then accumulate in the liver through the blood circulation system, and finally redistribute in various tissues. If fish are exposed to water that contains Cd ions for a long time, the Cd content in the liver exceeds its detoxification capacity, which affects the structural and functional integrity of fish liver tissue to different degrees [ 94 , 95 ]. With the increase in Cd concentration, the degree of irreversible damage to the structure of fish liver cells also increases significantly, which mainly includes endoplasmic reticulum expansion, nuclear deformation, nuclear membrane mitochondrial swelling, distortion, granular cytoplasm, and cell edema and cavitation.…”
Section: Toxic Effects Of Cadmium Accumulation On Fishmentioning
confidence: 99%
“…The toxic effect of Cd on fish is mainly reflected in the oxidative stress caused by ROS, and the excessive accumulation of ROS will lead to structural changes in biological macromolecules, such as proteins and DNA, disorder of DNA replication and repair, and eventually pathological changes [ 141 ]. At the same time, ROS can cause unsaturated fatty acids on the cell membrane lipid peroxidation reaction to produce malondialdehyde (MDA) and cause cell membrane structural damage, in addition, MDA itself is a kind of toxic substance [ 94 , 142 ]. Combined, all of these factors will further affect the function of enzymes related to regulating cell proliferation and differentiation and apoptosis on the membrane, finally causing a series of functional disorders and damage to the body [ 94 , 143 , 144 ].…”
Section: Mechanism Of the Toxic Effects Of Cadmium Exposure On Fishmentioning
confidence: 99%