Exposure to ZnO nanoparticles alters neuronal and vascular development in zebrafish: Acute and transgenerational effects mitigated with dissolved organic matter

Kteeba, Shimaa M.; El-Ghobashy, Ahmed E.; El-Adawi, Hala; El-Rayis, Osman A.; Sreevidya, Virinchipuram S.; Guo, Laodong; Svoboda, Kurt R.

doi:10.1016/j.envpol.2018.06.030

Cited by 33 publications

(12 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure to high concentration of ZnO NPs (2000 µg/l) and Ag NPs (4 mg/l) resulted in a destructive effect on the brain antioxidant system, while the low concentration (500 µg/l) of ZnO NPs and (2 mg/l) of Ag NPs produced completely opposite effect, supporting the antioxidant activity [121,122]. In the study on zebrafish, ZnO NPs impaired development of the nervous and vascular system [123]. Waterborn exposure to Ag NPs resulted in the presence of NPs in the brain of medaka (Oryzias latipes) [124].…”

Section: Toxicity In Non-mammalian Vertebratesmentioning

confidence: 84%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

View full text Add to dashboard Cite

Metallic nanoparticles due to their small size and unique physico-chemical characteristics have found excellent applications in various branches of industry and medicine. Therefore, for many years a growing interest has been observed among the scientific community in the improvement of our understanding of the impact of nanoparticles on the living organisms, especially on humans. Considering the delicate structure of the central nervous systemit is one of the organs most vulnerable to the adverse effects of metallic nanoparticles. For that reason, it is important to identify the modes of exposure and understand the mechanisms of the effect of nanoparticles on neuronal tissue. In this review, an attempt is undertaken to present current knowledge about metallic nanoparticles neurotoxicity based on the selected scientific publications. The route of entry of nanoparticles is described, as well as their distribution, penetration through the cell membrane and the blood-brain barrier. In addition, a study on the neurotoxicity in vitro and in vivo is presented, as well as some of the mechanisms that may be responsible for the negative effects of metallic nanoparticles on the central nervous system. Graphical abstract: This review summarizes the current knowledge on the toxicity of metallic NPs in the brain and central nervous system of the higher vertebrates.

show abstract

Section: Toxicity In Non-mammalian Vertebratesmentioning

confidence: 84%

Toxicity of metallic nanoparticles in the central nervous system

Sawicki

Czajka

Matysiak‐Kucharek

et al. 2019

Nanotechnology Reviews

View full text Add to dashboard Cite

show abstract

“…However, these abnormal phenotypes may be mitigated by DOM, indicating that the rich organic material in natural waters can substantially reduce the risk of ENMs. [168] Another reported study demonstrated that HA did not alter the biological fate of Ag NPs in adult D. rerio, rather, decreasing bioavailability, organ accumulation, toxicity, and fish mortality. [169] In the presence of HA and FA, the penetration of Ag NPs into internal tissues following oral ingestion by D. rerio may be markedly inhibited, further decreasing bioaccumulation and affecting the tissue distribution of Ag NPs.…”

Section: (10 Of 23)mentioning

confidence: 99%

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Wang

et al. 2020

Small

View full text Add to dashboard Cite

In aquatic environments, a large number of ecological macromolecules (e.g., natural organic matter (NOM), extracellular polymeric substances (EPS), and proteins) can adsorb onto the surface of engineered nanomaterials (ENMs) to form a unique environmental corona. The presence of environmental corona as an eco–nano interface can significantly alter the bioavailability, biocompatibility, and toxicity of pristine ENMs to aquatic organisms. However, as an emerging field, research on the impact of the environmental corona on the fate and behavior of ENMs in aquatic environments is still in its infancy. To promote a deeper understanding of its importance in driving or moderating ENM toxicity, this study systemically recapitulates the literature of representative types of macromolecules that are adsorbed onto ENMs; these constitute the environmental corona, including NOM, EPS, proteins, and surfactants. Next, the ecotoxicological effects of environmental corona‐coated ENMs on representative aquatic organisms at different trophic levels are discussed in comparison to pristine ENMs, based on the reported studies. According to this analysis, molecular mechanisms triggered by pristine and environmental corona‐coated ENMs are compared, including membrane adhesion, membrane damage, cellular internalization, oxidative stress, immunotoxicity, genotoxicity, and reproductive toxicity. Finally, current knowledge gaps and challenges in this field are discussed from the ecotoxicology perspective.

show abstract

“…Alterations in blood flow during embryonal development are often associated with heart defects in the adult stage [48]. Moreover, recent work in zebrafish reported that a reduction of blood flow and vessel diameters in ZnO NP-and ceramide-treated embryos is related to abnormal blood vessel development [49,50]. The primitive circulatory system in zebrafish consists of the dorsal aorta and cardinal vein [51].…”

Section: Resveratrol Ameliorates Morphological Vascular Modificationsmentioning

confidence: 99%

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

Giordo

Nasrallah

Al-Jamal

et al. 2020

IJMS

View full text Add to dashboard Cite

Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity.

show abstract

Exposure to ZnO nanoparticles alters neuronal and vascular development in zebrafish: Acute and transgenerational effects mitigated with dissolved organic matter

Cited by 33 publications

References 55 publications

Toxicity of metallic nanoparticles in the central nervous system

Toxicity of metallic nanoparticles in the central nervous system

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

Contact Info

Product

Resources

About