Exposure with the environmental estrogen bisphenol a disrupts the male reproductive tract in young mice

Takao, Toshihiro; Nanamiya, Wakako; Nagano, Isao; Asaba, Koichi; Kono, Kenji; Hashimoto, Kozo

doi:10.1016/s0024-3205(99)00502-0

Cited by 118 publications

(67 citation statements)

References 25 publications

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“…In males the slight changes observed point to an effect of prenatal BPA in inducing more defensive-type strategies during agonistic encounters and in slowing the copulatory sequence, but we also observed a reduction of sexual performance in postnatally treated animals. On the whole, in both sexes, sexual activity seems quite sensitive to perinatal exposure to BPA, in line with recent research showing significant effects on behavior and on reproductive indices after early BPA administration (9,10,18,19). The direction of the observed modifications in the two sexes in our experiment suggests that the effect of early BPA exposure on adult behavior may not be mediated by a classic organizational process activated by estrogenic action.…”

Section: Discussionsupporting

confidence: 91%

Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.

Farabollini

Porrini

Seta

et al. 2002

Environ Health Perspect

188

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Perinatal action of estrogens or aromatizable steroids at the central nervous system level is responsible for brain sexual differentiation. Through early contact with the central nervous system, the estrogenic compound bisphenol A (BPA) could alter the processes affecting sociosexual behavior. To test this hypothesis, we studied agonistic and sexual behavior of adult female and male rats whose mothers were administered BPA (40 microg/kg/day) during pregnancy or lactation. An intruder test revealed in males but not in females an increase in defensive behavior due to BPA. We studied the effect of BPA on sexual behavior by testing sexual orientation and sexual activity. Male sexual orientation toward a stimulus female was not affected by BPA, whereas the sexual activity test revealed a slight impairment of sexual performance due to BPA in terms of latency and frequency of intromissions. In females, BPA produced a small increase in sexual motivation and receptive behavior. In conclusion, BPA administration, both during pregnancy and during lactation, does not masculinize female behavior or potentiate masculinization processes of males. On the contrary, we observed a potentiation of female behavior in females and a depotentiation of male behavior in males.

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Section: Discussionsupporting

confidence: 91%

Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.

Farabollini

Porrini

Seta

et al. 2002

Environ Health Perspect

188

View full text Add to dashboard Cite

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“…Several toxicological studies (25) pointed out that rodents exposed to BPA during the prenatal or perinatal period show a large variety of adverse reproductive outcomes, including decreased epididymal weight and daily sperm production (26,27) and increased prostate weight (28), which is somewhat similar to our findings. With respect to the prepubertal or pubertal exposures, rodent studies have described a dramatic decrease in testosterone (T) levels (29,30) and epididymal sperm counts (29) after BPA exposure. After being exposed to BPA at a dose of 25 or 100 ng/kg, adult male mice showed a significant reduction in testicular as well as epididymal sperm counts (31).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Hasanluyi

Khojasteh

Nejhad

2016

Thrita

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Background: Bisphenol A is a xenoestrogen, synthesized in large quantities for the production of polymers (polycarbonates, epoxy resins) and thermal paper, and is widely used in products of everyday use (packaging, containers and bottles). Data concerning the occurrence of BPA in food, water and indoor environments as well as its appearance in tissues and body fluids of the human body are available in the literature. Male accessory sex glands are also vulnerable to environmental endocrine disruptors with adverse effects in adulthood. The developing prostate gland is particularly sensitive to estrogens and high-dose exposures during a critical developmental window results in intraepithelial prostatic neoplasia (PIN) in adult rodent models. Bisphenol A is also an endocrine disruptor. High levels of BPA exposure correlate with increased risk of mammary gland, brain and prostate cancers and have adverse effects on the tissues of the prostate and seminal vesicles. Objectives: The aim of this study was to investigate the effects of BPA doses on the histological structure and ultrastructure of prostate and seminal vesicle glands. Methods: Forty male Wistar rats were randomly divided into four groups (n = 10): A control group and three treatment groups,

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“…Several drugs, such as Bisphenol A (Li et al, 2009), increase apoptotic cell types within either the seminiferous epithelium (spermatogonia, primary spermatocytes and spermatids) or the interstitium (Leydig cells), causing loss of germ cell lineages and decreased fertility rates, as well as decrease in plasma testosterone levels and testis weight, associated with morphological changes, sperm count and motility (Takao et al, 1999;Aikawa et al, 2004). Germ cell apoptosis can also be related to a combination of factors, such as alterations in hormonal parameters and testicular oxidative stress (Chaki et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

et al. 2011

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The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion. Therefore, the present study was designed to analyze whether the association of the plant infusion and endurance exercise could potentiate the stimulating effect. The animals were separated into 4 groups: two control (sedentary and trained) receiving water and two treated (sedentary and trained) receiving the plant infusion daily (104mg/day). The proportion of the seminiferous tubule compartment and interstitium was analyzed. Within the seminiferous epithelium, the number of Sertoli and germ cells were counted in order to evaluate whether the treatment would alter the spermatogenic dynamics, analyzing: the spermatogenic yield, the mitotic and meiotic indexes, the total number of germ cells and the Sertoli cell support capacity. Trained and treated animals showed increased spermatogenic yield and spermatogonia mitosis, and no signifi cant differences in apoptotic indexes. Despite the results showing the same pattern regarding yield and mitotic index, the meiotic index was higher in the sedentary/treated group. Therefore, the H. aphrodisiaca infusion increased both the testosterone production and the spermatogonia mitosis, thus increasing the spermatogenic yield.

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Exposure with the environmental estrogen bisphenol a disrupts the male reproductive tract in young mice

Cited by 118 publications

References 25 publications

Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.

Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats.

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages

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