Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway

Kaur, Geetika; Kumar, B. V. Sunil; Singh, Baljit; Sethi, R. S.

doi:10.1186/s12995-021-00304-4

Cited by 10 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[85]. Farmworkers and their adult family members are at high risk of developing cancer due to the increased incidence of lung, breast, skin, lip, and kidney cancer in agricultural communities [86][87][88].…”

Section: Cancermentioning

confidence: 99%

Pesticide residue exposure effect on health, growth, and development among children from agricultural area

Deviyani,

Salami,

Oginawati

2024

E3S Web of Conf.

View full text Add to dashboard Cite

Nowadays, the exposure to pesticides has become a matter of public health concern. The primary and secondary take-home exposure of pesticides may influence the health of communities. Farmworkers’ families generally live close to agricultural areas, which may increase the risk of residential pesticide exposure. Pesticide exposure affects children more than adults. Environmental quality drives the shifting patterns of children’s major health problems, from infectious to chronic diseases. Children’s developing organs may be exposed to low-dose concentrations of environmentally disruptive pesticides such as organophosphates, organochlorines, carbamates, and pyrethroids. Several groups of pesticide metabolites induce and inhibit growth and development in children. Potential health problems such as chronic respiratory disease, asthma, and wheezing in children were more often reported from agricultural communities than children from rural areas. Children who were in contact with pesticides during both their prenatal development and childhood reported diminished cognitive scores. This can be attributable to the elevated levels of pesticides found in their urine, which have been extensively documented. Diammonium phosphate (DAP) metabolites as one of the organophosphate pesticides (OPPs) residues correlate with high KIM-1 levels in urine, significantly leading to chronic kidney disease. DNA damage may be A potential reported effect in children from agricultural communities. Thus, to ensure children’s health and development, it is necessary to strengthen the impact of pesticide studies on children.

show abstract

Section: Cancermentioning

confidence: 99%

Pesticide residue exposure effect on health, growth, and development among children from agricultural area

Deviyani,

Salami,

Oginawati

2024

E3S Web of Conf.

View full text Add to dashboard Cite

show abstract

“…Agent Orange, a mixture of herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-Trichlorophenoxyacetic acid (2,4,5-T), kerosene, and diesel fuel, was used in the Vietnam War to clear dense vegetation and destroy food crops. A potential association between 2,4-D and 2,4,5-T exposure [1][2][3] increased the risk of non-Hodgkin lymphoma, soft-tissue sarcoma, and bladder and lung cancers and has been debated since the 1980s [4], though no adequate epidemiological evidence has supported that conclusion [5]. Agent Orange and early formulations of 2,4-D and 2,4,5-T, were contaminated with a dioxin compound known as 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD), which has SHORT REPORT ACTA ONCOLOGICA 2024, VOL.…”

Section: Introductionmentioning

confidence: 99%

Agent orange exposure and prostate cancer risk in the million veteran program

Pagadala,

Lui,

Zhong

et al. 2024

View full text Add to dashboard Cite

Background: The US government considers veterans to have been exposed to Agent Orange if they served in Vietnam while the carcinogen was in use, and these veterans are often deemed at high risk of prostate cancer (PCa). Here, we assess whether presumed Agent Orange exposure is independently associated with increased risk of any metastatic or fatal PCa in a diverse Veteran cohort still alive in the modern era (at least 2011), when accounting for race/ethnicity, family history, and genetic risk. Patients and Methods: Participants in the Million Veteran Program (MVP; enrollment began in 2011) who were on active duty during the Vietnam War era (August 1964-April 1975) were included (n = 301,470). Agent Orange exposure was determined using the US government definition. Genetic risk was assessed via a validated polygenic hazard score. Associations with age at diagnosis of any PCa, metastatic PCa, and death from PCa were assessed via Cox proportional hazards models. Results and Interpretation: On univariable analysis, exposure to Agent Orange was not associated with increased PCa (hazard ratio [HR]: 1.02, 95% confidence interval [CI]: 1.00–1.04, p = 0.06), metastatic PCa (HR: 0.98, 95% CI: 0.91–1.05, p = 0.55), or fatal PCa (HR: 0.94, 95% CI: 0.79–1.09, p = 0.41). When accounting for race/ethnicity and family history, Agent Orange exposure was independently associated with slightly increased risk of PCa (HR: 1.06, 95% CI: 1.04–1.09, <10-6) but not with metastatic PCa (HR: 1.07, 95% CI: 0.98–1.15, p = 0.10) or PCa death (HR: 1.02, 95% CI: 0.83–1.23, p = 0.09). Similar results were found when accounting for genetic risk. Agent Orange exposure history may not improve modern PCa risk stratification.

show abstract

Digital image processing: a useful tool in the analysis of lung injuries caused by chronic inhalation of agricultural herbicides

Pedrassoli

Cavallieri

Silva

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used in agriculture to control various weeds. The objective of this study was to use the digital image processing method to identify alveolar lesions in the lungs of rats submitted to chronic 2,4-dichlorophenoxyacetic acid (2,4-D) inhalation exposure. We used forty adult male Wistar rats. The rats were divided into four groups: control group (CG), low concentration group (LCG), medium concentration group (MCG), and high concentration group (HCG). In a 6-month exposure period, we used two boxes connected to ultrasonic nebulizers for herbicide spraying. After this period, the rats were euthanized for the collection and study of lung tissue. For each image, counts of injuries and blisters were performed automatically using a methodology based on digital image processing techniques. For analysis of the results, an electronic database (Excel®) was created. We used the Pearson method for correlation analysis; values of p <0.05 were considered significant. In the evaluation of healthy alveoli, we recorded positive and significant correlations between analysis from a pathologist and computational analysis. In the evaluation of injured alveoli, we recorded a positive but non-significant correlation between analysis from a pathologist and computational analysis. These results show the effectiveness of digital image processing when evaluating alveolar integrity.

show abstract

Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway

Cited by 10 publications

References 65 publications

Pesticide residue exposure effect on health, growth, and development among children from agricultural area

Pesticide residue exposure effect on health, growth, and development among children from agricultural area

Agent orange exposure and prostate cancer risk in the million veteran program

Digital image processing: a useful tool in the analysis of lung injuries caused by chronic inhalation of agricultural herbicides

Contact Info

Product

Resources

About