Expresión de la Interleucina 10 (IL-10) y el Factor de Crecimiento Transformante Beta (TGF-ß) en Mucosa Intestinal de Crías de Alpaca (Vicugna pacos)

Burga, C Cesar; Manchego, S Alberto; Castro, S Gina; Pérez, Giancarlo; Ramírez, V Mercy; Sandoval, C Nieves

doi:10.15381/rivep.v28i2.13082

Cited by 1 publication

(2 citation statements)

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“…Conversely, regulatory cytokines, including IL-10 and TGF-β, function as crucial modulators to prevent excessive inflammation and immunopathology. They regulate the intensity of the immune response, thus balancing the protective immunity against the parasites with the potential for immune-mediated tissue damage 11 . The delicate equilibrium between pro-inflammatory and anti-inflammatory cytokines throughout the course of infection profoundly impacts disease severity and outcome.…”

Section: Cytokines In the Pathogenesis Of Malariamentioning

confidence: 99%

“…Simultaneously, regulatory cytokines, notably interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), act as modulators, preventing excessive inflammation and immune-mediated tissue damage. This delicate balance ensures effective parasite clearance while limiting host-induced pathology 6 – 11 . As the infection progresses, the adaptive immune response comes into play, marked by the activation of T cells and the production of antibodies 12 .…”

Section: Introductionmentioning

confidence: 99%

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Role of cytokines in immunomodulation during malaria clearance

Obeagu

2024

Annals of Medicine &Amp; Surgery

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Malaria remains a significant global health challenge, demanding a deeper understanding of host immune responses for effective clearance of the parasitic infection. Cytokines, as crucial mediators of the immune system, orchestrate a complex interplay during the various stages of malaria infection. Throughout the course of the disease, an intricate balance of pro-inflammatory and anti-inflammatory cytokines dictate the immune response’s outcome, influencing parasitic clearance and disease severity. During the initial stages, interleukins such as IL-12, IFN-γ, and TNF-α play pivotal roles in activating innate immune cells, initiating the anti-parasitic response. Simultaneously, regulatory cytokines like IL-10 and TGF-β modulate this immune activation, preventing excessive inflammation and tissue damage. As the infection progresses, a delicate shift occurs, characterized by a transition to adaptive immunity, guided by cytokines like IL-4, IL-5, and IL-13, promoting antibody production and T-cell responses. Notably, the resolution of malaria infection crucially relies on a fine-tuned balance of cytokine networks. Dysregulation or imbalances in these mediators often result in immune hyperactivation, contributing to severe manifestations and prolonged infection. Understanding the multifaceted roles of cytokines in malaria clearance offers promising avenues for therapeutic interventions. Targeting cytokine pathways to restore immune equilibrium or bolster protective responses could potentially enhance treatment strategies and vaccine development. In conclusion, the pivotal role of cytokines in immunomodulation during malaria clearance underscores their significance as potential targets for therapeutic interventions, offering promising prospects in the global fight against this infectious disease.

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Section: Cytokines In the Pathogenesis Of Malariamentioning

confidence: 99%