Express evaluation of antioxidant activity of uracil derivatives

Gimadieva, A. R.; Khazimullina, Yu. Z.; Belaya, E. A.; Zimin, Yu. S.; Абдрахманов, И. Б.; Мустафин, А. Г.

doi:10.18097/pbmc20156106765

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…The total antioxidant capacity of extracts was determined by the photometric FRAP method on a spectrophotometer SF-2000 (OCB «Spectr», Russia) using the methodology [14] in our own modification [13]. Results were expressed in µmol equiv.…”

Section: Methodsmentioning

confidence: 99%

Search for Alternative Sources of Natural Plant Antioxidants for Food Industry

Kupaeva

Kotenkova

2019

Food systems

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According to the data of the Food and Agriculture Organization of the United Nations, global food losses are about one third of their total output, mainly due to spoilage. Therefore, a search for safe methods of shelf life extension is an important task, especially for products for specialized nutrition. According to literature data, natural antioxidants can be alternative to existing preservatives due to its ability to inhibit oxidation of the main nutrients. Pulp, seeds and peel of quince, apple «Simirenko», feijoa, persimmon, Jerusalem artichoke, white, red and yellow onion were objects of the study. The total antioxidant capacity was determined by Oxygen Radical Absorbance Capacity (ORAC) and Ferric Reducing Antioxidant Power (FRAP) methods and expressed in µmol equiv. Trolox / g of sample and µmol equiv. Dihydroquercetin / g of sample. It was noticed that peels demonstrated higher antioxidant activity, and red onion husk possessed the highest value, which was 722.8 ± 13.9 µmol equiv. Dihydroquercetin / g of sample and 3357.5 ± 42.2 µmol equiv. Trolox / g of sample. It was shown that the use of fruit and vegetable wastes is promising for production of food-grade antioxidants. In addition, the results of the research could facilitate stimulation of rational and efficient environmental management.

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Section: Methodsmentioning

confidence: 99%

Search for Alternative Sources of Natural Plant Antioxidants for Food Industry

Kupaeva

Kotenkova

2019

Food systems

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“…Cytosine derivatives has been reported to be resistant against mycobacteria and some Gram-positive and Gram-negative bacteria [32]. Additionally, uracil derivatives also had the anti-oxidant ability based on the assay of DPPH free radical scavenging (5aminouracil (IC50: 3 mg/mL), 5-amino-6-methyluracil (IC50: 5 mg/mL), and 5-hydroxy-6-methyluracil (IC50: 15 mg/mL) [34].…”

Section: Thin-layer Chromatography Analysis Of the Purified Anti-mrsa...mentioning

confidence: 99%

Purification of Bioactive Compound from Endophytes Bacillus sp. RD26 of Phyllanthus amarus Schum. et Thonn

Minh¹,

Phat²,

Linh³

2021

Pharmacophore

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The strain of Bacillus sp. RD26, isolated from Phyllanthus amarus Schum. et Thonn. exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). In the current study, Bacillus sp. RD26 was identified as Bacillus amyloliquefaciens according to Cowan and Steel classification keys. The methanol extract (BRM) from Bacillus amyloliquefaciens RD26 was resistant to MRSA bacteria with an inhibition zone of 25 ± 0.57 mm. From total BRM, the highefficient column chromatographic extraction was conducted with solvent system EA:Me (the ration of EA: Me were 100:0; 90:10; 80:20; 70:30; 60:40; and 0:100) to collect total of five fractions (BRM1 -BRM5). As the result, all fractions had antibacterial activity against MRSA. Among them, the fraction of BRM3 had the highest anti-MRSA ability with the zone of inhibition reached to 18 mm. Combining the method of column chromatographic extraction and thin-layer chromatographic extraction, the compound of BR04, pyrimidine-2,4-dion (Uracil), which had the anti-MRSA ability, was isolated. BR04 was identified to be resistant to many Gram-positive and Gram-negative bacteria such as MRSA, Bacillus cereus, Escherichia coli by evaluation of MIC. The values of MIC were 64 μg/mL, 128 μg/mL, and 512 μg/mL for MRSA, Bacillus cereus, and Escherichia coli, respectively. Additionally, BR04 had antioxidant activity at the concentration of 1800 μg/mL. In conclusion, the current study reported bioactive compounds from Bacillus amyloliquefaciens RD26 had the potential to be further applied against infectious microorganisms.

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“…The uracil-metal complexes can have square planar and octahedral geometries [3,4]. Uracil's substituted in position five stand out in bioactivity, with various biological activities including antiviral properties, anticancer, cytotoxic, anti-mycobacterial, and antitumor, to antibacterial [14][15][16][17][18][19][20][21][22][23]. In this manuscript we aim to synthesize new Mg(II), Ca(II), Sr(II) and Ba(II) complexes of uracil and report an assessment of their coordination behavior using spectral measurements and thermal studies.…”

Section: Introductionmentioning

confidence: 99%

Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis

A.O. Younes,

S. Refat,

A. Saad

et al. 2023

Bull. Chem. Soc. Eth.

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ABSTRACT. Magnesium, calcium, strontium, and barium complexes of uracil were prepared in a 2:1 ligand to metal ratio to investigate the ligational character of the uracil (Ura). The modes of chelation were explained depending on elemental analyses, FT. IR, 1H–NMR spectra as well as scanning electron microscopy. Uracil has two donation sites either through N(3) and C(2)=O, or through N(3) and C(4)=O with the molecular formulas [M(Ura)2(H2O)2]Cl2 where M = Mg(II), Ca(II), Sr(II) and Ba(II) . The morphological surface and particle size of uracil metal complexes were determined using SEM and TEM. The thermal behaviors of the complexes were studied by the TGA (DTG) technique. The data obtained agreed well the proposed structures and showed that the complexes were finally decomposed to the corresponding metal oxide. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz–Metzger methods. The negative values of deduced the ordered structures of the prepared complexes compared to their starting reactants. Antibacterial activity of ligands and complexes is evaluated with two types of bacteria Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) by the agar-well diffusion technique using DMSO as a solvent. KEY WORDS: Uracil, Coordination compounds, Non-isothermal kinetic parameters, Elemental analysis, Spectral studies, Biological efficiency Bull. Chem. Soc. Ethiop. 2023, 37(4), 945-957. DOI: https://dx.doi.org/10.4314/bcse.v37i4.11

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Express evaluation of antioxidant activity of uracil derivatives

Cited by 6 publications

References 2 publications

Search for Alternative Sources of Natural Plant Antioxidants for Food Industry

Search for Alternative Sources of Natural Plant Antioxidants for Food Industry

Purification of Bioactive Compound from Endophytes Bacillus sp. RD26 of Phyllanthus amarus Schum. et Thonn

Complexation of some alkaline earth metals with bidentate uracil ligand: Synthesis, spectroscopic and antimicrobial analysis

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