Expression analysis and regulation of GLI and its correlation with stemness and metabolic alteration in human brain tumor

Agrawal, Kirti; Chauhan, Saumya; Kumar, Dhruv

doi:10.1007/s13205-022-03419-5

Cited by 5 publications

(6 citation statements)

References 49 publications

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“…Since more than a quarter of MB patients show activation of the SHH signaling pathway shown by GLI2/1 immunopositivity, 11 , 39 activated forms of GLI2 preserve pathway activity and support survival of the tumor cells, indicating GLI2 activity as a key driver for MB. 40 High level of Gli2 expression has been shown in several mouse models, but as mentioned, the overexpression alone is not sufficient to drive MB development, 20 , 21 , 22 but basal cell carcinoma (BCC) in the skin.…”

Section: Discussionmentioning

confidence: 99%

“…In SHH-MB, GLI2 occurs in combination with amplifications of NMYC or deletion of TP53. 6 , 10 , 11 MB is the most common malignant brain tumor in children, representing 60% of childhood intracranial embryonal tumors and the leading cause of pediatric cancer deaths. 6 , 12 , 13 While PTCH1 mutations occur at all ages in SHH-MB, SUFU mutations are enriched in infant SHH-MB, and SHH-MB in adolescence/adulthood often harbors SMO mutations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

Niesen¹,

Hermans‐Borgmeyer²,

Krüger³

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

Niesen¹,

Hermans‐Borgmeyer²,

Krüger³

et al. 2023

iScience

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“…Recent investigations have highlighted the sonic hedgehog (SHH) signaling pathway as a crucial player in the proliferation and cell fate specification of stem cells [112,113]. The GLI gene-mediated hedgehog (Hh) pathway plays an essential role in different types of brain cancer, including lower-grade glioma (LGG), glioblastomas (GBM) and medulloblastomas (MB).…”

Section: Signaling Pathways In Glioma Cancer Stem Cellsmentioning

confidence: 99%

“…Stemness-related factors of GSC, namely SOX2, SOX9, POU5F1 and NANOG demonstrate correlation to GLI genes. The expression of transcription factors, GLI2 and GLI3 is increased in the aforementioned tumors with poor patient survival [113]. A study on patient-derived GSC cultures by Liu and collaborators (2022) [114] indicated that Islet 1 (ISL1), a member of the homeodomain transcription factors, knockdown decreased the proliferation and promoted the apoptosis of human-derived GSC.…”

Section: Signaling Pathways In Glioma Cancer Stem Cellsmentioning

confidence: 99%

Glioma Stem Cells—Features for New Therapy Design

Pećina-Šlaus,

Hrašćan

2024

Cancers

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On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cells that behave like stem cells and are known as glioma cancer stem cells (GCSCs). They are responsible for tumor plasticity and are influenced by genetic drivers. Additionally, GCSCs also display greater migratory abilities. A great effort is under way in order to find ways to eliminate or neutralize GCSCs. Many different treatment strategies are currently being explored, including modulation of the tumor microenvironment, posttranscriptional regulation, epigenetic modulation and immunotherapy.

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“…Further, the high expression of ACAT1 (HR = 0.44), GLUD1 (HR = 0.41), SLC38A1 (HR = 0.61), and SLC38A2 (HR = 0.63) are significantly correlated with good prognosis in LGG patients, while high expression of AHR (HR = 1.78), ENO1 (HR = 1.69), HK2 (HR = 3.56), MTOR (HR = 1.71), NFATC2 (HR = 2.16), SLC16A4 (HR = 2.92), SLC1A5 (HR = 3.00), SLC36A4 (HR = 1.67), and XBP1 (HR = 1.82) are correlated with poor prognosis in LGG patients. The expression of enolase 1 (ENO1) and hexokinase 2 (HK2) has been shown to play an important role in the occurrence and metastasis of glioma cells [21,22]. Considering individual cancers, the prognoses of eighteen cancers are significantly correlated with at least one MCG.…”

Section: Significant Correlation Between the Pan-cancer Survival And ...mentioning

confidence: 99%

Pan-Cancer Identification of Prognostic-Associated Metabolic Pathways

Chen

Zhao

et al. 2023

Biology

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Metabolic dysregulation has been reported involving in the clinical outcomes of multiple cancers. However, systematical identification of the impact of metabolic pathways on cancer prognosis is still lacking. Here, we performed a pan-cancer analysis of popular metabolic checkpoint genes and pathways with cancer prognosis by integrating information of clinical survival with gene expression and pathway activity in multiple cancer patients. By discarding the effects of age and sex, we revealed extensive and significant associations between the survival of cancer patients and the expression of metabolic checkpoint genes, as well as the activities of three primary metabolic pathways: amino acid metabolism, carbohydrate metabolism, lipid metabolism, and eight nonprimary metabolic pathways. Among multiple cancers, we found the survival of kidney renal clear cell carcinoma and low-grade glioma exhibit high metabolic dependence. Our work systematically assesses the impact of metabolic checkpoint genes and pathways on cancer prognosis, providing clues for further study of cancer diagnosis and therapy.

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Expression analysis and regulation of GLI and its correlation with stemness and metabolic alteration in human brain tumor

Cited by 5 publications

References 49 publications

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

Glioma Stem Cells—Features for New Therapy Design

Pan-Cancer Identification of Prognostic-Associated Metabolic Pathways

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