2018
DOI: 10.3233/cbm-170831
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Expression analysis of AFAP1-AS1 and AFAP1 in breast cancer

Abstract: Long non-coding RNAs (lncRNA) constitute a significant percentage of RNAs with no translation to proteins. Their participation in fundamental aspects of cell physiology as well as their dysregulation in a number of pathologic conditions such as cancer have been documented. Among lncRNAs is actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) whose elevated expression levels have been demonstrated in different cancers. In the in the present study we evaluated expression levels of AFAP1-AS1 and its ant… Show more

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Cited by 21 publications
(25 citation statements)
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“…Among putative bio markers for lung cancer are long non-coding RNAs (lncRNAs). These heterogeneous types of transcripts have various fundamental functions in gene regulation and are involved in the pathogenesis of human cancers [6][7][8][9][10][11]. A comprehensive study to find the lncRNA and mRNA signature in lung adenocarcinoma samples and normal tissues has identified more than two thousands lncRNAs with differential expression in these two sets of samples [12].…”
Section: Introductionmentioning
confidence: 99%
“…Among putative bio markers for lung cancer are long non-coding RNAs (lncRNAs). These heterogeneous types of transcripts have various fundamental functions in gene regulation and are involved in the pathogenesis of human cancers [6][7][8][9][10][11]. A comprehensive study to find the lncRNA and mRNA signature in lung adenocarcinoma samples and normal tissues has identified more than two thousands lncRNAs with differential expression in these two sets of samples [12].…”
Section: Introductionmentioning
confidence: 99%
“…13 Taken together, one can suggest that the effect of AFAP1-AS1 on expression of AFAP1 might be both context-and tissue-dependent. Such a correlation could not be detected in breast cancer tissues or their adjacent non-cancerous tissues.…”
Section: Discussionmentioning
confidence: 97%
“…Such a correlation could not be detected in breast cancer tissues or their adjacent non-cancerous tissues. 13 Taken together, one can suggest that the effect of AFAP1-AS1 on expression of AFAP1 might be both context-and tissue-dependent. Previous reports have shown both suppressive and inducing effects of naturally occurring antisense RNAs on expression of sense genes.…”
Section: Discussionmentioning
confidence: 97%
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